Pineal gland which regulates the cycles of sleep and waking evolved to improve vision

The pineal gland - which regulates the cycles of sleep and waking - appears to have evolved as an indirect way to improve vision, by keeping toxic compounds away from the eye, according to a new theory by a researcher at the National Institute of Child Health and Human Development at the National Institutes of Health.

The theory has implications for understanding macular degeneration, a condition causing vision loss in people age 60 and older.

The theory is described in the August Journal of Biological Rhythms and represents the work of David Klein, Ph.D., Chief of NICHD's Section on Neuroendocrinology. Dr. Klein studies melatonin, the pineal hormone that regulates sleep and wake cycles.

"Dr. Klein's theory extends our understanding of the pineal gland as a factor controlling the body's daily rhythms," said Duane Alexander, M.D., Director of the National Institute of Child Health and Human Development. "Klein's new theory reminds us of the common evolutionary origin of cells in the pineal gland and retina and forces us to look at one of the enzymes used to make melatonin from a new perspective - as a detoxifying system in the retina."

Briefly, the theory holds that melatonin was at first a kind of cellular garbage, a by-product created in cells of the eye when normally toxic substances were rendered harmless. Roughly 500 million years ago, however, the ancestors of today's animals became dependent on melatonin as a signal of darkness. As the need for greater quantities of melatonin grew, the pineal gland developed as a structure separate from the eyes, to keep the toxic substances needed to make melatonin away from sensitive eye tissue.

For sight to be possible, Dr. Klein explained, a form of vitamin A (also called retinaldehyde) must chemically attach itself to rhodopsin, a protein found in the light detecting cells of the retina (the photoreceptors). When struck by light, the retinaldehyde-rhodopsin combination undergoes physical changes that begin a series of chemical reactions. These reactions ultimately generate an electrical signal that travels into the brain, making vision possible.

This is a one-time event for each retinal-rhodopsin combination. In the process, light also renders the retinaldehyde inactive and frees it from rhodopsin. The free, inactive retinaldehyde is then recycled within the retina to an active form, so that it can again participate in light detection.

However, a problem arises during this recycling process: When retinaldehyde is not attached to rhodopsin, it can combine with substances known as arylalkylamines. Klein has found that one molecule of an arylalkylamine can combine with two molecules of retinaldehyde to form a substance known as a bis-retinal arylalkylamine. After this occurs, the retinaldehyde molecule can no longer be used to detect light, Dr. Klein said. Arylalkylamines are potentially dangerous because they can damage many chemicals in the cell. Some arylalkylamines are generated naturally. These include tyramine, tryptamine, phenylethylamine, and serotonin. In addition, Dr. Klein theorizes that other toxic arylalkyamines were also present in the environment early in evolution.

Roughly 500 million years ago, animals acquired the ability to make an enzyme known as arylalkylamine N-acetyltransferase (AANAT). Earlier this year, Dr. Klein and his colleagues presented evidence that animal cells may have acquired this ability by incorporating bacterial DNA into their own DNA. A release describing the earlier finding appears at

AANAT chemically alters arylalkylamines to prevent them from combining with retinaldehyde. AANAT alters serotonin by changing it to a compound known as N-acetylserotonin. However, N-acetylserotonin is still toxic to the cells of the retina, although less so than is serotonin. A second enzyme, hydroxyindole-O-methyltransferase (HIOMT) further changed N-acetylserotonin, converting it into melatonin, which is relatively harmless to the eye. In the earlier paper, Dr. Klein and his coworkers also provided evidence that, like AANAT, HIOMT originated in bacteria. He believes that these enzymes - both of which are essential for melatonin synthesis - were acquired by the ancestral eye to increase sensitivity to light. The enzymes presumably were acquired before the evolution of the pineal gland.

Dr. Klein explained that, in the ancestor of today's higher animals, the conversion of serotonin to melatonin increased at night, as a way to make vision more sensitive to low light conditions. The conversion kept serotonin from combining with retinaldehyde at night, when it was needed to detect low levels of light, so that these ancestral animals could function well under dim light.

Gradually, the early organism recognized the increase in melatonin as a signal of nighttime and became dependent on it, according to Dr. Klein's theory. This signal was used to synchronize their daily cycles with the environmental night and day cycle. For this signal to be reliable, the organism needed a steady supply of serotonin in these cells. However, this requirement for higher levels of serotonin conflicted with the need for greater light detection because serotonin depleted retinaldehyde. This conflict was resolved by the evolution of a second photoreceptor cell, one that housed melatonin production. The evolution of the second photoreceptor cell allowed the original photoreceptor cell to achieve higher levels of sensitivity to light because it was not dedicated to making high levels of melatonin. Eventually, the melatonin-making photoreceptors gave rise to the pineal gland.

"To increase both sets of processes - melatonin synthesis and photodetection - evolution put them into separate cells," Dr. Klein said. "One cell moved toward detecting light, the other toward making melatonin."

In support of his theory, Dr. Klein noted that the photoreceptor cells of the retina strongly resemble the cells of the pineal gland and that the pineal cells of sub-mammals (such as fish, frogs and birds) detect light. In addition, melatonin's origin in the ancestral photoreceptor cell is indicated by the capacity of the retinas of mice, fish, frogs, and birds to make low amounts of melatonin.

Dr. Klein points out that as humans and other primates evolved, melatonin production was lost in the retina and became restricted to the pineal gland. Although melatonin is no longer manufactured in the primate retina, AANAT still is. Dr. Klein suspects that the enzyme plays a role in protecting the human retina. Arylalkylamines (tryptamine, phenylethylamine, and tyramine) are likely to be made in cells of the retina, and AANAT may function to convert them to less harmful forms.

Accordingly, AANAT may play two roles - in the retina it would have a detoxification role whereas in the pineal gland it would have a role in melatonin synthesis It's possible, Dr. Klein said, that low levels of AANAT might lead to the deterioration of the retina seen in macular degeneration; and, perhaps it might be possible to prevent this disease by increasing AANAT levels.


  1. Ginnie Ginnie Canada says:

    Many years ago I had a seizure and as a result lost the ability to sleep without drugs for 10 years.  Gradually over 30 years with lots of help, I have been healing.  However, 4 years ago I had emergency surgery to resolve a large macular hole and detached retina.  I knew instinctively that this recent eye op was related to the earlier health problem.  I could explain why but it would take many words.  I never knew until I read your site that 'sleep' and the 'macular' and 'retina' were related to each other.  I just happened to hear a news report in which there was a statement referring to 'the gland that regulates sleep'.  I didn't know there was such a thing.  I googled it and found your site.  My sleep although much better than 30 years ago can still use help.  Do you have any suggestions?

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