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Psychological traits may uncover why Alzheimer’s biology differs between patients

In 822 deceased older adults from ROS and MAP, researchers linked stable psychological traits to multi-omic molecular subtypes of Alzheimer’s dementia using postmortem brain tissue from the dorsolateral prefrontal cortex. Neuroticism and loneliness were associated with molecular progression, while purpose in life showed subtype-specific inverse associations, suggesting psychological traits may align with Alzheimer’s biology beyond conventional neuropathology.

22 Jun 2026

Amazon land use patterns reveal where vector-borne diseases collide

Researchers found that malaria-Chagas and dengue-ATL hotspots in the Brazilian Amazon aligned with distinct agrarian, socioeconomic, and environmental landscapes. The findings suggest that disease surveillance should account for land use, poverty, forest structure, mining, and local livelihoods rather than treating each infection in isolation.

22 Jun 2026

Statins may trigger muscle side effects by activating inflammatory danger signals

An experimental study in Science Advances shows that statins, primarily fluvastatin in these experiments, may promote low-level muscle myopathy by reducing isoprenoid-dependent protein prenylation rather than by cholesterol lowering. In primed muscle cells and mouse models, impaired YAP signaling, reduced glycolysis, NLRP3/caspase-1 activation, and nuclear FOXO accumulation increased atrogin-1, reduced protein synthesis, and weakened muscle function.

22 Jun 2026

Scientists trace cardiac aging to a fading regulator in heart muscle cells

Researchers mapped 442,239 single nuclei from nonfailing human hearts to chart how cardiac cells change from fetal development to older adulthood. The study identified PRDM16 as an age-declining cardiomyocyte regulator, with experimental evidence showing that restoring Prdm16 in aged mouse hearts improved systolic function and partly reversed aging-associated transcriptional patterns.

22 Jun 2026

Prime and pull vaccine approach prevents genital herpes infection

Genital herpes is a lifelong infection. While available treatments can manage symptoms, they cannot cure the infection or prevent transmission.

22 Jun 2026

UCLA researcher receives grant for advanced osteosarcoma immunotherapy

Physician-scientist Theodore Scott Nowicki, MD, PhD, an assistant professor in the department of pediatrics hematology/oncology and microbiology, immunology, & molecular genetics at the David Geffen School of Medicine at UCLA, has been awarded the Hero Grant from MIB Agents, a nonprofit organization dedicated to improving outcomes for children and young adults with osteosarcoma.

22 Jun 2026

Natural molecule erucamide helps slow progressive retinal degeneration

Many conditions that cause vision loss share a common feature: the gradual breakdown of the retina, the light-sensing tissue at the back of the eye.

22 Jun 2026

Brainstem neurons found to control attention by suppressing distractions

Neurons tucked away in an ancient part of the brain control the ability to pay attention by suppressing distractions and directing focus.

22 Jun 2026

Most adults with depression favor informal community peer support

As mental health needs continue to rise in Singapore, researchers from Duke-NUS Medical School, working with collaborators, including the Institute of Mental Health (IMH), have found that most adults living with symptoms of anxiety or depression are open to receiving support from peers, even if they have not sought professional help.

22 Jun 2026

Review outlines how donor imaging improves liver transplantation outcomes

Liver transplantation often depends on decisions made under pressure. In deceased donation, teams must quickly judge whether a liver is suitable, whether fat accumulation could threaten graft function, and whether unexpected vascular anatomy may complicate procurement or implantation.

22 Jun 2026

Ultrasound therapy improves poststroke motor coordination in mouse model

Following stroke, patients have a hard time performing coordinated movements. Transcranial ultrasound stimulation (TUS) is emerging as a treatment to improve poststroke coordination, but the mechanisms for this motor improvement remain unclear.

22 Jun 2026

Australian research uncovers how the brain manages unexpected sensory surprises

Australian researchers have uncovered what happens behind the scenes in our brain when we're faced with a predictable situation versus a surprise, giving vital clues in a long-standing mystery in neuroscience.

22 Jun 2026

Copper-induced cell death stimulates antitumor immune cell responses

A preclinical study from researchers at The University of Texas MD Anderson Cancer Center, published today in Cell, details a connection between the immune system and cuproptosis, a type of copper-induced cell death.

22 Jun 2026

Engineered CAR-T cells offer potential rheumatoid arthritis cure

For the 18 million people living with rheumatoid arthritis, disease management currently means a lifetime of injections-a reality that new research from Tsinghua University may soon begin to change.

22 Jun 2026

Study identifies risk factors for early-onset colorectal cancer

A recent study found that factors such as a person's birthweight, sex, ethnicity, and father's age may affect the risk of being diagnosed with colorectal cancer at a young age.

22 Jun 2026

Immunotherapy helps bridge cancer patients to curative liver transplantation

Liver transplantation remains one of the most powerful curative options for hepatocellular carcinoma (HCC) because it removes both the tumor and the diseased liver.

22 Jun 2026

Early screen time may impact subsequent academic performance and working memory

The World Health Organization (WHO) and the American Academy of Pediatrics recommend no screen time before 18-24 months and less than one hour per day for children ages 2 to 5.

22 Jun 2026

Neuroscience research questions traditional markers for cerebellar movement disorders

A new finding by a Virginia Tech neuroscientist at the Fralin Biomedical Research Institute at VTC is challenging the way investigators study chronic neurological disorders such as dystonia, ataxia, and tremor.

22 Jun 2026

Study links genes and sleep habits to Alzheimer's risk

New research from Edith Cowan University (ECU) has discovered an important link between our genes and sleep habits, suggesting they work together to influence early brain and cognitive changes associated with Alzheimer's Disease, long before symptoms appear.

22 Jun 2026

Mount Sinai study connects social determinants of health to disease risks

A new study from the Icahn School of Medicine at Mount Sinai shows that social determinants of health-including environmental conditions, health behaviors, access to resources, and social well-being-can play an equally important or even greater role than genetics in predicting a person's risk of developing common diseases.

22 Jun 2026