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Topadur’s Phase 2a trial of TOP-N53 for systemic sclerosis-associated digital ulcers advances to next dose levels

Topadur Pharma AG, a Swiss clinical-stage biopharmaceutical company, today announced that the Safety Review Committee of its Phase 2a trial has recommended progression to the next planned dose levels.

5 Nov 2026

Elusive HIV strains cause breakthrough infections after antibody treatment ends

The broadly neutralizing antibody VRC01 has been thoroughly vetted as a potential prophylactic that could prevent people from becoming infected with HIV.

5 Nov 2026

Public health experts demand tighter global restrictions on fireworks

Fireworks pose an underestimated danger to public health and require stronger regulations and sustained public education campaigns to help prevent devastating, yet entirely avoidable injuries, warn US experts in The BMJ today.

5 Nov 2026

Engineered IL-39 cytokine unlocks new pathways for immunotherapy

In a new preclinical study, scientists present a molecular engineering approach to modify and repurpose a cytokine named IL-39, which plays a central role in inflammation and immunity.

5 Nov 2026

Implantable AI signal processing optimizes adaptive deep brain stimulation therapy

A research team led by Professor Ji-Woong Choi of the Department of Electrical Engineering and Computer Science at DGIST (President Kunwoo Lee), in collaboration with research teams led by Professor Han-Joon Kim of Kumoh National Institute of Technology, Professor Kyong Hwan Jin of Korea University, and Dr. Jong-Cheol Rah of the Korea Brain Research Institute, has developed "NONOS," a deep-learning-based analysis technology that precisely separates "rhythms" from the underlying "background signals" in brain signals with high temporal resolution.

5 Nov 2026

Graded physical activity prescriptions improve functional outcomes in psychiatry

Most of us have heard the advice so often that it has worn smooth, like a stone in a river: get some exercise. A new peer-reviewed Viewpoint in Brain Health, drawing on randomized trials, meta-analyses, and cohort studies, argues that this familiar sentence has been doing the wrong job.

5 Nov 2026

Organoid coculture platforms enhance preclinical prediction of drug efficacy

Three‐dimensional cancer organoids cultured in vitro closely recapitulate the phenotypic and genetic features of parental tumor tissues, making them powerful tools for cancer research, drug screening, and personalized medicine.

5 Nov 2026

Temporary ultrasonic sensor provides continuous feedback during spinal cord healing

Following a $13.48 million dollar award from the defense department, a team of engineers and surgeons from Johns Hopkins Medicine have published their first proof-of-concept study that shows temporarily implanting a tiny ultrasonic device into the location of a spinal cord injury can be feasible, safe and potentially useful.

5 Nov 2026

Modified zinc finger scaffold suppresses microglial activation in mouse brain

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease. The approach also reduced the toxicity of protein aggregates that had already formed.

5 Nov 2026

New tool identifies older adults at risk of delirium and falls from anticholinergic medications

Researchers funded by Health Data Research UK (HDR UK) have developed a new tool to help doctors and pharmacists identify older patients at risk of delirium and serious falls associated with taking multiple anticholinergic medications.

5 Nov 2026

Tau spreads more rapidly in early-onset Alzheimer's disease

Patients with early-onset Alzheimer's disease, whose symptoms start before age 65, have more extensive deposits of tau, a hallmark protein of the condition, compared with patients whose symptoms start at 65-plus, a new study found.

5 Nov 2026

Brain scans reveal clues to Alzheimer's risk years before memory loss begins

Inside the brains of some cognitively normal adults, firing patterns were able to foretell Alzheimer's disease years before the onset of memory loss or the accumulation of plaques and tangles, according to new Stanford Medicine-led research.

5 Nov 2026

Targeting brain protein may help treat MEF2C-related neurological disorders

A particular signaling protein in the brain could be a therapeutic target for neurological disorders arising from the deletion of the autism-linked gene MEF2C, University of Illinois Urbana-Champaign researchers found in a new mouse study.

4 Nov 2026

ACS Emergency General Surgery Verification associated with fewer deaths and shorter stays

Patients treated at hospitals that earned American College of Surgeons (ACS) Emergency General Surgery Verification demonstrated lower 30-day death rates and experienced shorter hospital stays after their hospitals earned verification, according to an analysis published in JAMA Surgery.

4 Nov 2026

UCLA advances CRISPR gene-editing therapy for sickle cell disease

A UCLA-led team has described how they advanced an experimental CRISPR approach for sickle cell disease into a blood stem cell therapy that can be manufactured at the scale and quality required for a clinical trial.

4 Nov 2026

Workplace exposure to petroleum-based lubricants linked to higher MS risk

Exposure to petroleum-derived lubricants at work, including engine oil, hydraulic oil and cutting fluids used to cool or lubricate metal during metalworking, is associated with higher odds of multiple sclerosis (MS), according to a study published November 4, 2026, in Neurology, the medical journal of the American Academy of Neurology.

4 Nov 2026

Longer reproductive lifespan and hormonal history may influence brain vascular health

A longer reproductive lifespan and a history of using birth control pills or menopausal hormone therapy were associated with certain signs of blood vessel health in the brain, according to a study published November 4, 2026, in Neurology, the medical journal of the American Academy of Neurology.

4 Nov 2026

Psychedelics linked to lingering visual disturbances resembling early psychosis

Every night, as he fell asleep, a 25-year-old man saw an eye in his ceiling. It was huge and unblinking, and it felt as if the whole world was being sucked into it.

4 Nov 2026

Bed bug infestations affect communities across all socioeconomic groups

Rather than being a poverty problem, bed bugs are actually everyone's problem.

4 Nov 2026

Women with DCIS may not need routine imaging after double mastectomy

Women who have undergone a double mastectomy to treat ductal carcinoma in situ (DCIS), a noninvasive form of breast cancer also known as stage 0 breast cancer, may not benefit from routine mammograms or other breast imaging after surgery, according to a new study led by investigators at the UCLA Health Jonsson Comprehensive Cancer Center.

4 Nov 2026

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Medical Research News

Topadur’s Phase 2a trial of TOP-N53 for systemic sclerosis-associated digital ulcers advances to next dose levels

Elusive HIV strains cause breakthrough infections after antibody treatment ends

Public health experts demand tighter global restrictions on fireworks

Engineered IL-39 cytokine unlocks new pathways for immunotherapy

Implantable AI signal processing optimizes adaptive deep brain stimulation therapy

Graded physical activity prescriptions improve functional outcomes in psychiatry

Organoid coculture platforms enhance preclinical prediction of drug efficacy

Temporary ultrasonic sensor provides continuous feedback during spinal cord healing

Modified zinc finger scaffold suppresses microglial activation in mouse brain

New tool identifies older adults at risk of delirium and falls from anticholinergic medications

Tau spreads more rapidly in early-onset Alzheimer's disease

Brain scans reveal clues to Alzheimer's risk years before memory loss begins

Targeting brain protein may help treat MEF2C-related neurological disorders

ACS Emergency General Surgery Verification associated with fewer deaths and shorter stays

UCLA advances CRISPR gene-editing therapy for sickle cell disease

Workplace exposure to petroleum-based lubricants linked to higher MS risk

Longer reproductive lifespan and hormonal history may influence brain vascular health

Psychedelics linked to lingering visual disturbances resembling early psychosis

Bed bug infestations affect communities across all socioeconomic groups

Women with DCIS may not need routine imaging after double mastectomy

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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