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Identifying the ages when Alzheimer’s biomarkers sharply change

New research identifies critical ages for Alzheimer's biomarkers, enhancing screening strategies and understanding neurodegeneration across the aging spectrum.

1 May 2026

Food timing may shape how T cells respond to infection and therapy

Short-term nutritional state can reshape T cell metabolism, with post-meal lipid metabolism enhancing T cell metabolic capacity, cytokine production, and persistence after activation. The study identifies triglyceride-rich chylomicrons as key drivers of this effect, suggesting nutritional timing may matter for immune monitoring, vaccination research, and cell-therapy manufacturing.

30 Apr 2026

Five-target drug beats GLP-1/GIP therapy in obese diabetic mice

A Nature study reports a single-molecule GLP-1–GIP–lanifibranor quintuple agonist that targets incretin receptor-expressing cells while activating PPARα/γ/δ pathways. In obese and insulin-resistant mice, the compound reduced body weight, food intake, and hyperglycaemia more effectively than semaglutide or GLP-1R–GIPR co-agonism, while remaining a preclinical finding.

30 Apr 2026

New genetic risk report reveals hidden heart disease risk before symptoms appear

Researchers developed and externally validated integrated polygenic risk scores for eight cardiovascular conditions using large U.S.-based biobank data. The clinically orderable report may help identify inherited cardiovascular risk that traditional clinical markers can miss, although broader prospective validation is still needed.

30 Apr 2026

AgentClinic puts medical AI through a more realistic diagnostic test

AgentClinic is a multimodal benchmark that tests clinical AI agents in simulated, dialogue-driven diagnostic settings rather than static medical question-answer formats. The study found that model performance varied sharply by tool use, language, bias, image handling, and patient-agent interactions, highlighting the need for more realistic AI evaluation before clinical deployment.

30 Apr 2026

New CAR T cell design boosts persistence and reduces toxicity

CAR T-cell therapy has transformed the treatment of hematologic malignancies, yet many patients do not achieve lasting benefit – often because the infused cells fail to expand or persist.

30 Apr 2026

Study reveals new immune mechanism behind mevalonate kinase deficiency

Researchers at the Garvan Institute of Medical Research have uncovered a critical mechanism driving inflammation in mevalonate kinase deficiency (MKD), a rare but devastating autoinflammatory disorder.

30 Apr 2026

Molecular switch protein Ten4 guides neuron migration in the developing brain

During brain development, neurons can regulate their movement until they reach their final destination thanks to a "molecular switch" involving the protein Teneurin 4 (Ten4).

30 Apr 2026

Brain blips in epilepsy can be predicted before onset

Epilepsy is best known for seizures, but many people with the condition also experience much more frequent and subtler disruptions.

30 Apr 2026

Early institutional care linked to shorter life expectancy decades later

Infants who grew up in early child care institutions in the 1950s have a much shorter life expectancy than the general population, a long-term study of individuals in Zurich has shown

30 Apr 2026

New review questions whether vaping consistently helps smokers quit

A new review paper in Nicotine and Tobacco Research, published by Oxford University Press, finds that while research has previously found that vaping is associated with subsequently quitting smoking, that may not always be true.

30 Apr 2026

Pathogens drive inflammation by reprogramming host cell metabolic processes

An intestinal pathogen reshapes the gut environment to fuel its own colonization and cause diseases, a multi-institutional team including researchers at Vanderbilt Health has discovered.

30 Apr 2026

Sickness behavior may be a coordinated whole organism immune strategy

Symptoms such as fatigue, loss of appetite, altered sleep, and social withdrawal are often treated as inconvenient side effects of infection.

30 Apr 2026

Strategic social network targeting produces greatest reduction in smoking

Targeting only a small group of well-connected individuals with smoking reduction interventions produces the largest reductions in smoking, researchers report.

30 Apr 2026

Dangerous water bead ingestions increase among young children

A new study reveals that ingestions of water beads by young children have surged in recent years. Researchers at the Center for Injury Research and Policy of the Abigail Wexner Research Institute at Nationwide Children's Hospital and the Central Ohio Poison Center analyzed calls to U.S. poison centers and found an alarming 6,532% increase in the rate of reported water bead ingestions among children younger than 6 years from 2019 to 2023, followed by a 24% decrease from 2023 to 2024.

30 Apr 2026

Liquid biopsy predicts immune response in high-risk breast cancer patients

Immunotherapy has become a standard of care in treating high-risk, early-stage breast cancers, yet it has had limited success in shrinking tumors.

30 Apr 2026

Eliminating animal products reshapes metabolic health and environmental impact

A new randomized clinical trial provides some of the clearest evidence to date that what we eat can meaningfully reshape both human health and the health of the planet.

30 Apr 2026

NIH awards $44 million for landmark study on health challenges in the rural South

The University of Texas at San Antonio (UT San Antonio) has been awarded a five-year, $44 million contract from the National Heart, Lung, and Blood Institute of the National Institutes of Health for a landmark study focused on persistent health challenges in the rural South.

30 Apr 2026

Degeneration in two brain regions causes severe narcolepsy symptoms

For nearly 25 years, scientists believed they knew what caused the most severe form of narcolepsy. A new UCLA Health study now suggests they were only half correct.

30 Apr 2026

Scientists discover a potential new way to slow ALS disease progression

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the progressive loss of motor neurons, which in most cases leads to respiratory failure within three to five years after diagnosis.

30 Apr 2026