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Mitotane’s role in the management of adrenocortical carcinoma

Adrenocortical carcinoma (ACC) is a rare but aggressive malignancy with high postoperative recurrence rates and poor prognosis. Mitotane remains the only approved agent for ACC, exerting antitumor effects by disrupting mitochondrial integrity, inhibiting steroidogenic enzymes, and interfering with cholesterol metabolism.

21 Jan 2026

Analyzing bacterial enzymes in pikromycin synthesis

Macrolides are an important class of antibiotics that includes drugs such as azithromycin and erythromycin, which are widely used to treat a range of infections, including pneumonia and skin infections.

21 Jan 2026

A dual-action approach to preventing hepatocellular carcinoma

Hepatocellular carcinoma is one of the leading causes of cancer-related death worldwide, largely due to its high rate of recurrence after surgery. Even after complete tumor removal, microscopic residual disease and early dissemination frequently lead to relapse within the first two years.

21 Jan 2026

Tracing the decline in American heart disease mortality

Following a five-year upward trend likely impacted by the COVID pandemic, the number of heart disease and stroke deaths has declined, yet, heart disease and stroke still kill more people in the U.S. each year than any other cause, according to data reported in the 2026 Heart Disease and Stroke Statistics: A Report of U.S. and Global Data From the American Heart Association.

21 Jan 2026

Cannabis legalization drives rising use among adults with historically lower consumption

A new study led by Boston College School of Social Work Professor Summer Sherburne Hawkins found that recreational cannabis legalization in the United States is driving increases in cannabis use among adults with historically lower consumption, as opposed to increasing use among those who already consumed cannabis.

21 Jan 2026

Mouse study reveals social hierarchy influences sleep quality during isolation

Researchers tested what factors improve or worsen the quality of sleep in mice. A team including researchers from the University of Tokyo placed mice in two environments, one where they could see and sense other mice without physical contact, and one in complete isolation.

21 Jan 2026

Arthritis significantly restricts employment for millions of American adults

According to new research from the University of Delaware, nearly 40% of American adults ages 18 to 64 with arthritis - almost 10 million people - say the medical condition is limiting their ability to work.

21 Jan 2026

Severe vitamin D deficiency linked to higher hospitalizations for respiratory tract infections

Severe vitamin D deficiency is associated with a higher rate of hospitalization for respiratory tract infections such as bronchitis and pneumonia, according to a new study led by the University of Surrey.

21 Jan 2026

Suppressing brain immune cells enhances memory recall in young mice

Babies of every species from mouse to human rapidly forget things that happen to them-an effect called infantile amnesia.

20 Jan 2026

Machine learning enables prosthetic hands to control grip for daily tasks

Holding an egg requires a gentle touch. Squeeze too hard, and you'll make a mess. Opening a water bottle, on the other hand, needs a little more grip strength.

20 Jan 2026

Weill Cornell Medicine receives ARPA-H award to advance lymphatic disease diagnosis

Weill Cornell Medicine has received a $5.2 million, initial two-year award from the Advanced Research Projects Agency for Health (ARPA-H) Lymphatic Imaging, Genomics, and pHenotyping Technologies (LIGHT) program to develop a comprehensive and innovative approach to diagnosing lymphatic disease.

20 Jan 2026

Mcgill researchers find unexpected chemical contaminants in human milk samples

An interdisciplinary team including researchers at McGill University has found a range of unexpected chemical contaminants in human milk samples from Canada and South Africa.

20 Jan 2026

Study examines cannabis use among street-identified Black Americans facing gun violence

Yasser Payne grew up in Harlem, New York, where violence was all around him. A number of his family members and friends were shot. He himself was subject to gun violence and witnessed fights.

20 Jan 2026

Prenatal wildfire smoke exposure linked to higher autism risk in children

Exposure to wildfire smoke during the final months of pregnancy may raise the risk that a child is later diagnosed with autism, according to a new study led by Tulane University researchers.

20 Jan 2026

Early treatment delays rheumatoid arthritis onset in high-risk individuals

Treating people who are at high risk of rheumatoid arthritis (RA) can delay the onset of the disease for several years, with benefits also continuing well after treatment has stopped.

20 Jan 2026

Diverse exercise routines associated with reduced risk of death

Regularly doing a mix of different types of physical activity may be best for prolonging the lifespan, but the associations aren't linear, pointing to a possible optimal threshold effect, suggests research published in the open access journal BMJ Medicine.

20 Jan 2026

Landmark UK study supports nationwide screening for childhood type 1 diabetes

A landmark UK study involving tens of thousands of families has shown that childhood screening for type 1 diabetes is effective, laying the groundwork for a UK-wide childhood screening program.

20 Jan 2026

Lifestyle prevention of diabetes may halve carbon footprint associated with treating complications

Preventing high blood glucose (pre-diabetes) from turning into type 2 diabetes with lifestyle changes could more than halve the carbon footprint associated with treating the complications of the disease, suggests a modelling study, published in the open access journal BMJ Open.

20 Jan 2026

Rhythmic carbon dioxide exposure may enhance brain waste clearance mechanisms

Abnormal clumps of proteins like α-synuclein, amyloid beta and tau are associated with neurodegenerative conditions like Parkinson's and Alzheimer's disease, but a waste removal mechanism called the glymphatic pathway can clear these proteins and other metabolic byproducts from the brain.

20 Jan 2026

UK glaucoma cases expected to rise sharply due to aging population

The number of people over 40 in the UK living with glaucoma-the leading cause of irreversible blindness worldwide-is already higher than expected and is projected to surge to more than 1.6 million by 2060, finds research published online in the British Journal of Ophthalmology.

20 Jan 2026