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Review explores intrinsic mechanisms driving right ventricular remodeling in pulmonary arterial hypertension

Announcing a new article publication for Cardiovascular Innovations and Applications. Pulmonary arterial hypertension (PAH) comprises a group of progressive pulmonary circulatory diseases characterized by a persistent increase in pulmonary vascular resistance.

5 Nov 2026

New covalent inhibitor targets DNAJC9 to reduce sepsis inflammation

This new article publication from Acta Pharmaceutica Sinica B discusses the discovery of the covalent inhibitor A12 and the identification of DNAJC9 as a potential drug target for sepsis-associated inflammation.

5 Nov 2026

Delivering integrated HIV and substance use services through mobile units could save lives

Results from a clinical trial funded by the National Institutes of Health (NIH) in five major United States cities show that delivering integrated HIV and substance use disorder (SUD) services using peer navigation in mobile medical units reduced all-cause deaths by 71% compared to participants who received peer navigation to community-based services alone.

5 Nov 2026

Topadur’s Phase 2a trial of TOP-N53 for systemic sclerosis-associated digital ulcers advances to next dose levels

Topadur Pharma AG, a Swiss clinical-stage biopharmaceutical company, today announced that the Safety Review Committee of its Phase 2a trial has recommended progression to the next planned dose levels.

5 Nov 2026

Elusive HIV strains cause breakthrough infections after antibody treatment ends

The broadly neutralizing antibody VRC01 has been thoroughly vetted as a potential prophylactic that could prevent people from becoming infected with HIV.

5 Nov 2026

Public health experts demand tighter global restrictions on fireworks

Fireworks pose an underestimated danger to public health and require stronger regulations and sustained public education campaigns to help prevent devastating, yet entirely avoidable injuries, warn US experts in The BMJ today.

5 Nov 2026

Engineered IL-39 cytokine unlocks new pathways for immunotherapy

In a new preclinical study, scientists present a molecular engineering approach to modify and repurpose a cytokine named IL-39, which plays a central role in inflammation and immunity.

5 Nov 2026

Implantable AI signal processing optimizes adaptive deep brain stimulation therapy

A research team led by Professor Ji-Woong Choi of the Department of Electrical Engineering and Computer Science at DGIST (President Kunwoo Lee), in collaboration with research teams led by Professor Han-Joon Kim of Kumoh National Institute of Technology, Professor Kyong Hwan Jin of Korea University, and Dr. Jong-Cheol Rah of the Korea Brain Research Institute, has developed "NONOS," a deep-learning-based analysis technology that precisely separates "rhythms" from the underlying "background signals" in brain signals with high temporal resolution.

5 Nov 2026

Graded physical activity prescriptions improve functional outcomes in psychiatry

Most of us have heard the advice so often that it has worn smooth, like a stone in a river: get some exercise. A new peer-reviewed Viewpoint in Brain Health, drawing on randomized trials, meta-analyses, and cohort studies, argues that this familiar sentence has been doing the wrong job.

5 Nov 2026

Organoid coculture platforms enhance preclinical prediction of drug efficacy

Three‐dimensional cancer organoids cultured in vitro closely recapitulate the phenotypic and genetic features of parental tumor tissues, making them powerful tools for cancer research, drug screening, and personalized medicine.

5 Nov 2026

Temporary ultrasonic sensor provides continuous feedback during spinal cord healing

Following a $13.48 million dollar award from the defense department, a team of engineers and surgeons from Johns Hopkins Medicine have published their first proof-of-concept study that shows temporarily implanting a tiny ultrasonic device into the location of a spinal cord injury can be feasible, safe and potentially useful.

5 Nov 2026

Modified zinc finger scaffold suppresses microglial activation in mouse brain

A KAIST-led research team has found that a protein involved in gene regulation can suppress the harmful aggregation of amyloid-beta, a peptide associated with Alzheimer's disease. The approach also reduced the toxicity of protein aggregates that had already formed.

5 Nov 2026

New tool identifies older adults at risk of delirium and falls from anticholinergic medications

Researchers funded by Health Data Research UK (HDR UK) have developed a new tool to help doctors and pharmacists identify older patients at risk of delirium and serious falls associated with taking multiple anticholinergic medications.

5 Nov 2026

Tau spreads more rapidly in early-onset Alzheimer's disease

Patients with early-onset Alzheimer's disease, whose symptoms start before age 65, have more extensive deposits of tau, a hallmark protein of the condition, compared with patients whose symptoms start at 65-plus, a new study found.

5 Nov 2026

Brain scans reveal clues to Alzheimer's risk years before memory loss begins

Inside the brains of some cognitively normal adults, firing patterns were able to foretell Alzheimer's disease years before the onset of memory loss or the accumulation of plaques and tangles, according to new Stanford Medicine-led research.

5 Nov 2026

Targeting brain protein may help treat MEF2C-related neurological disorders

A particular signaling protein in the brain could be a therapeutic target for neurological disorders arising from the deletion of the autism-linked gene MEF2C, University of Illinois Urbana-Champaign researchers found in a new mouse study.

4 Nov 2026

ACS Emergency General Surgery Verification associated with fewer deaths and shorter stays

Patients treated at hospitals that earned American College of Surgeons (ACS) Emergency General Surgery Verification demonstrated lower 30-day death rates and experienced shorter hospital stays after their hospitals earned verification, according to an analysis published in JAMA Surgery.

4 Nov 2026

UCLA advances CRISPR gene-editing therapy for sickle cell disease

A UCLA-led team has described how they advanced an experimental CRISPR approach for sickle cell disease into a blood stem cell therapy that can be manufactured at the scale and quality required for a clinical trial.

4 Nov 2026

Workplace exposure to petroleum-based lubricants linked to higher MS risk

Exposure to petroleum-derived lubricants at work, including engine oil, hydraulic oil and cutting fluids used to cool or lubricate metal during metalworking, is associated with higher odds of multiple sclerosis (MS), according to a study published November 4, 2026, in Neurology, the medical journal of the American Academy of Neurology.

4 Nov 2026

Longer reproductive lifespan and hormonal history may influence brain vascular health

A longer reproductive lifespan and a history of using birth control pills or menopausal hormone therapy were associated with certain signs of blood vessel health in the brain, according to a study published November 4, 2026, in Neurology, the medical journal of the American Academy of Neurology.

4 Nov 2026

Medical Research News

Review explores intrinsic mechanisms driving right ventricular remodeling in pulmonary arterial hypertension

New covalent inhibitor targets DNAJC9 to reduce sepsis inflammation

Delivering integrated HIV and substance use services through mobile units could save lives

Topadur’s Phase 2a trial of TOP-N53 for systemic sclerosis-associated digital ulcers advances to next dose levels

Elusive HIV strains cause breakthrough infections after antibody treatment ends

Public health experts demand tighter global restrictions on fireworks

Engineered IL-39 cytokine unlocks new pathways for immunotherapy

Implantable AI signal processing optimizes adaptive deep brain stimulation therapy

Graded physical activity prescriptions improve functional outcomes in psychiatry

Organoid coculture platforms enhance preclinical prediction of drug efficacy

Temporary ultrasonic sensor provides continuous feedback during spinal cord healing

Modified zinc finger scaffold suppresses microglial activation in mouse brain

New tool identifies older adults at risk of delirium and falls from anticholinergic medications

Tau spreads more rapidly in early-onset Alzheimer's disease

Brain scans reveal clues to Alzheimer's risk years before memory loss begins

Targeting brain protein may help treat MEF2C-related neurological disorders

ACS Emergency General Surgery Verification associated with fewer deaths and shorter stays

UCLA advances CRISPR gene-editing therapy for sickle cell disease

Workplace exposure to petroleum-based lubricants linked to higher MS risk

Longer reproductive lifespan and hormonal history may influence brain vascular health

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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