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Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Researchers identified trimethylamine (TMA) as a gut microbe–derived metabolite that directly inhibits IRAK4 to reduce metabolic inflammation and improve glycaemic control in high-fat-diet-fed mice. Choline-driven increases in TMA production replicated these benefits, revealing a host–microbe signaling axis with therapeutic potential for obesity-associated insulin resistance.

9 Dec 2025

Study explains why mpox cases can appear weeks after exposure

Mpox virus clade Ib shows a longer and more variable incubation period than previously characterized clades, with symptom onset extending well beyond 21 days in a substantial minority of cases. Incubation varies by transmission route, with shorter intervals after sexual exposure and longer periods following nonsexual community transmission, raising implications for surveillance and postexposure guidance.

9 Dec 2025

A massive mid-14th-century volcanic eruption likely triggered the spread of the "Black Death"

A large volcanic eruption or cluster of eruptions in the mid-1340s triggered severe climate anomalies that drove harvest failures across parts of Europe. These shocks reshaped Mediterranean grain trade routes, likely introducing plague-infected fleas into Italian ports and helping ignite the Black Death.

9 Dec 2025

Prevention efforts for cannabis-impaired driving should also focus on older adults

With cannabis-related vehicle crashes on the rise, a new study suggests that prevention campaigns shouldn't focus just on young people.

9 Dec 2025

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

Researchers at the UCLA Health Jonsson Comprehensive Cancer Center have identified a small molecule that can inhibit a cancer-driving protein long considered impossible to target with drugs - a discovery that could open the door to a new class of treatments for leukemia and other hard-to-treat cancers.

9 Dec 2025

People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome

A new national study shows for the first time that people exposed to Agent Orange face a higher risk of developing myelodysplastic syndrome (MDS), tend to develop it earlier, and often have more aggressive disease that is more likely to progress to acute myeloid leukemia.

9 Dec 2025

WSU researchers discover how a neural circuit drives relapse after opioid use

Washington State University researchers have discovered how a neural circuit – or a connection between two brain regions – drives relapse after opioid use, a finding that could lead to more effective treatments for opioid use disorders.

9 Dec 2025

Negative health impacts caused by 'forever chemicals' linked to billions in economic losses

The negative health impacts from contamination by so called "forever chemicals" in drinking water costs the contiguous U.S. at least $8 billion a year in social costs, a University of Arizona-led study has found.

9 Dec 2025

Disinfectant used in water treatment may impact the incidence of Legionnaire's disease

Preliminary results of a nationwide study suggest that the disinfectant used to treat water before it is distributed through pipes may impact the incidence of Legionnaire's disease in certain parts of the country.

9 Dec 2025

Brain function discovery helps explain why childhood adversity raises metabolic disease risk in women

McGill University researchers have identified a brain function that helps explain why childhood stress raises metabolic health risks for some women later in life.

9 Dec 2025

Study uncovers how the body's bile acids bind to block C. diff's most dangerous toxin

In a major step towards a precision therapy for Clostridioides difficile (C. diff) infection, researchers at The Hospital for Sick Children (SickKids) have uncovered how the body's bile acids bind to block C. diff's most dangerous toxin.

9 Dec 2025

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

Reducing calorie intake helps cancer-fighting immune cells do their jobs more effectively, reports a study by Van Andel Institute scientists and collaborators.

9 Dec 2025

New study could lead to quicker and more targeted support for vulvodyniaia

A first-of-its-kind University of Stirling-led study could lead to quicker and more targeted support for vulvodynia - a painful chronic condition estimated to affect more than one in 10 women with no known cause.

9 Dec 2025

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

In a new preclinical study, researchers from The University of Texas MD Anderson Cancer Center developed an antibody therapy called 77A that showed an ability to overcome treatment resistance in blood cancers, such as myeloma and lymphoma, as well as solid tumors.

9 Dec 2025

Medical Research News

Gut microbe metabolite TMA improves blood sugar by shutting down a key inflammatory switch

Study explains why mpox cases can appear weeks after exposure

A massive mid-14th-century volcanic eruption likely triggered the spread of the "Black Death"

Prevention efforts for cannabis-impaired driving should also focus on older adults

Small molecule discovery could open the door to new class of treatments for hard-to-treat cancers

People exposed to Agent Orange face higher risk of developing myelodysplastic syndrome

WSU researchers discover how a neural circuit drives relapse after opioid use

Negative health impacts caused by 'forever chemicals' linked to billions in economic losses

Disinfectant used in water treatment may impact the incidence of Legionnaire's disease

Brain function discovery helps explain why childhood adversity raises metabolic disease risk in women

Study uncovers how the body's bile acids bind to block C. diff's most dangerous toxin

Dietary restriction reprograms cancer-fighting immune cells to enhance anti-tumour immunity

New study could lead to quicker and more targeted support for vulvodyniaia

New antibody shows ability to overcome treatment resistance in blood cancers and solid tumors

Australian researchers pinpoint specific genetic changes linked to severe AMD

New study reveals productivity losses from substance use disorder in the U.S.

Accuracy of remote photoplethysmography drops sharply at elevated heart rates

High BMI and poor physical fitness in adolescence linked to severe bacterial infections in adulthood

Physical activity may help restore ease of movement and agility during aging

Study reveals how brain protein KCC2 influences reward learning

Bioprocess Efficiency with Cell Density Monitoring

Exploring electron microscopy for plant and microbial imaging at the John Innes Centre

Extending the reach of Amperia™

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