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Fatbuster drug targets obesity

A new drug to combat obesity at a cellular level is in the sights of a University of Queensland scientist.

25 Oct 2004

Allopurinol, a common gout drug may also offer some protection against colorectal cancer

A commonly prescribed drug used to treat gout may also offer some protection against colorectal cancer, according to a new study from researchers at the University of Michigan and in Israel.

25 Oct 2004

Tabletop DNA test laboratory cuts disease diagnosis down to 30 minutes

British scientists have developed a tabletop DNA test laboratory that can cut the diagnosis of disease and infection from hours to 30 minutes. This new test laboratory will soon begin trials in UK hospitals.

24 Oct 2004

New evidence supports value of fruits and vegetables in reducing breast cancer risk

Fruits and vegetables are known to reduce the risk of some cancers. Their antioxidant properties have been found to inhibit the generation of reactive oxidant species (ROS) that can damage and change DNA and lead to cancer.

22 Oct 2004

Molecule that helps DNA replicate may make good target for cancer therapy

In order to divide, cells must first replicate their chromosomes. Cells use an array of proteins to accomplish the job, including a large enzyme complex that synthesizes new strands of DNA.

21 Oct 2004

Research findings will likely aid efforts to develop a vaccine for Leishmania major

Researchers at Washington University School of Medicine in St. Louis and the University of Pennsylvania have found an immune system cell can "remember" a parasite's attack and help the body mount a more effective defense against subsequent invasions by the same parasite.

21 Oct 2004

Possible link between elevated calcium levels in older neurons and aging-related disorders of the brain

Brain cells become increasingly unable to regulate calcium loads as they age, becoming more vulnerable to injury and premature death, according to new findings that Virginia Commonwealth University researchers will present at an international conference this month.

20 Oct 2004

Researchers are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes

Researchers at UT Southwestern Medical Center at Dallas are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes.

19 Oct 2004

Discovery might improve design, effectiveness of anti-cancer drugs

Working with an enzyme that degrades anti-cancer drugs in humans, University of North Carolina at Chapel Hill biochemists and colleagues have made a discovery that they believe eventually could help improve such drugs’ design and effectiveness.

18 Oct 2004

More efficient method to sequence the human genome

Researchers at Baylor College of Medicine have been tabbed to find a more efficient method to sequence the human genome.

18 Oct 2004

One in four deaths among women with heart failure can be attributed to kidney problems

About one in four deaths among women with heart failure can be attributed to kidney problems, and more deaths are linked to renal insufficiency than to any other single risk factor, according to a new study in the Oct. 19, 2004 issue of the Journal of the American College of Cardiology.

18 Oct 2004

COX-2 agents have influenced the way physicians prescribe rheumatology medication

COX-2 agents, with their perceived reduction in side effects, have contributed substantially to a dramatic increase in NSAIDs (non-steroidal anti-inflammatory drugs) prescription utilization and influenced the way physicians prescribe rheumatology medication

18 Oct 2004

Single protein appears central to the formation of the long-term memories

Researchers at the National Institute of Child Health and Human Development have discovered that a single protein appears central to the formation of the long-term memories.

16 Oct 2004

Robotic microscope shows how mutant Huntington's disease protein affects neurons

Using a specially designed robotic microscope to study cultured cells, researchers have found evidence that abnormal protein clumps called inclusion bodies in neurons from people with Huntington's disease (HD) prevent cell death.

13 Oct 2004

A new approach to controlling blood cholesterol levels may be a potential treatment for Alzheimer's disease

A new approach to controlling blood cholesterol levels that is already being investigated to prevent cardiovascular disease also may be a potential treatment for Alzheimer's disease.

13 Oct 2004

Discovery of compound that renders the MRSA superbug vulnerable to antibiotics

MRSA- methicillin-resistant Staphylococcus aureus- is defined by its ability to resist the antibiotic methicillin. Like penicillin, methicillin works by blocking bacterial enzymes called PBPs, which normally strengthen cell walls by forming cross links.

13 Oct 2004

Estrogen protects male rats from aortic aneurysms

When it comes to abdominal aortic aneurysms – life-threatening bulges or weak areas in the main artery feeding blood to the lower half of the body – new U-M research shows that it is definitely better to be female.

12 Oct 2004

Discovery of naturally occurring RNA "switches" that manage the amino acid glycine

Two University of Washington computer scientists are part of a team that has discovered a pair of rare, naturally occurring RNA "switches" in a class of bacteria that work cooperatively to manage the amino acid glycine.

11 Oct 2004

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease, according to a study published in the October 12 issue of Neurology, the scientific journal of the American Academy of Neurology.

11 Oct 2004

Progestin in hormone therapy could dramatically affect heart attack severity

“One type of hormone therapy limited heart muscle damage to only 5 percent while another resulted in permanent damage to 35 percent of muscle,” said J. Koudy Williams, Ph.D., lead investigator, from Wake Forest Baptist. “If we can learn more about this mechanism we might be able to identify better hormone therapies for postmenopausal women.”

10 Oct 2004

Enzyme News and Research

Fatbuster drug targets obesity

Allopurinol, a common gout drug may also offer some protection against colorectal cancer

Tabletop DNA test laboratory cuts disease diagnosis down to 30 minutes

New evidence supports value of fruits and vegetables in reducing breast cancer risk

Molecule that helps DNA replicate may make good target for cancer therapy

Research findings will likely aid efforts to develop a vaccine for Leishmania major

Possible link between elevated calcium levels in older neurons and aging-related disorders of the brain

Researchers are one step closer to understanding how high carbohydrate diets lead to obesity and diabetes

Discovery might improve design, effectiveness of anti-cancer drugs

More efficient method to sequence the human genome

One in four deaths among women with heart failure can be attributed to kidney problems

COX-2 agents have influenced the way physicians prescribe rheumatology medication

Single protein appears central to the formation of the long-term memories

Robotic microscope shows how mutant Huntington's disease protein affects neurons

A new approach to controlling blood cholesterol levels may be a potential treatment for Alzheimer's disease

Discovery of compound that renders the MRSA superbug vulnerable to antibiotics

Estrogen protects male rats from aortic aneurysms

Discovery of naturally occurring RNA "switches" that manage the amino acid glycine

Certain blood pressure drugs may slow the deterioration of Alzheimer's disease

Progestin in hormone therapy could dramatically affect heart attack severity

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