Fluorescence News and Research

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Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates

Using a synthetic peptide modeled after the protein that the human immunodeficiency virus (HIV) uses to enter cells, a multi-institutional research team has created quantum dots that can penetrate the cell membrane and image internal structures in a cell.

10 Jul 2006

Nanoscale metal-organic frameworks as potential multimodal contrast enhancing agents

By combining the properties of inorganic and organic molecules in one material, researchers at the Carolina Center of Cancer Nanotechnology Excellence (CCNE) have developed a new class of nanomaterials that can be used to create multifunctional nanoparticles.

10 Jul 2006

Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas

Most attempts to develop imaging agents that can better distinguish tumors from healthy tissue focus on finding molecules that are more abundant on malignant cells than on normal cells and using those as cellular targets.

10 Jul 2006

Bone marrow adult stem cells repair a damaged heart

Researchers at the McEwen Centre for Regenerative Medicine at Toronto General Hospital have discovered the 'SOS' distress signal that mobilizes specific heart repair cells from the bone marrow to the injured heart after a heart attack.

3 Jul 2006

3 new genes implicated in rheumatoid arthritis

Researchers continue to search for genetic clues into rheumatoid arthritis (RA), a chronic inflammatory joint disease.

27 Jun 2006

The protein that makes you mad

In recent years our feeding habits have been the focus of ongoing polemics. Everybody will remember the "mad cow" crisis.

26 Jun 2006

New roles for growth factors

During embryonic development, nerve cells hesitantly extend tentacle-like protrusions called axons that sniff their way through a labyrinth of attractive and repulsive chemical cues that guide them to their target.

18 Jun 2006

Circulating bone-marrow derived cells do not contribute to egg formation

Ovulated egg cells, or oocytes, in adult female mice are not formed from germ cells in the blood or bone marrow.

14 Jun 2006

Scientists watch the behavior of a single gene in real time

Scientists at the Albert Einstein College of Medicine of Yeshiva University have observed for the first time that gene expression can occur in the form of discrete "pulses" of gene activity.

14 Jun 2006

Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose

One of the body's basic survival mechanisms is the neural machinery that triggers the hungry brain to the alertness needed for seeking food.

From The University of Manchester 7 Jun 2006

Telomere erosion may lead to shorter life expectancy in men

This new study published in the journal "Cytogenetic and Genome Research" shows significantly shorter telomeres and higher erosion rates in men than in women, which likely causes a shorter life expectancy of male cells and tissues.

17 May 2006

Dynamics of drying DNA droplets on glass surfaces

Coffee drinkers are familiar with the ring-shaped stains that result from spilled drops that have dried, in which the brown stain is not evenly distributed, but instead concentrated at the edge.

11 May 2006

Neurons can produce Alzheimer's-linked apolipoprotein E

A question long debated among Alzheimer's disease researchers has been definitively answered by scientists at the Gladstone Institute of Neurological Disease in San Francisco.

10 May 2006

Stem cell 'fusion' occurs in tumors

An Oregon Health & Science University study is adding credence to an increasingly popular theory that fusion is what bonds stem cells with bone marrow cells to regenerate organ tissue.

10 May 2006

New insight into the way an embryonic retina cell develops

The discovery provides a new vantage point for understanding how a healthy visual system develops. It also raises the possibility of re-directing the production of cell types as needed to stave off eye disease.

9 May 2006

Nanoparticle system for imaging and delivering drugs to tumors

By melding magnetic and luminescent properties with an easily modified surface, a team of investigators at the National Research Council of Canada have created what could prove to be a highly versatile nanoparticle system for imaging and delivering drugs to tumors.

9 May 2006

Effective gene suppression using small interfering RNA in hard-to-transfect human T cells

A technical advance in laboratory techniques may provide biology researchers broader access to RNA interference, a process of blocking the activity of targeted genes. RNA interference has recently emerged as an important tool in studying how genes function in normal biological processes and in disease.

9 May 2006

Gene silencing protein discovered

A team of researchers, including biologists at Washington University in St. Louis, has discovered the key role one protein plays in a major turn-off -in this case, the turning off of thousands of nearly identical genes in a hybrid plant.

8 May 2006

Combination of genetic mutation and viral infection may cause prostate cancer

Significant recent interest in the literature (JAMA 2006;295:1503, Lancet, epub) and by patients has arisen in response to a presentation given by Dr. Eric Klein of the Cleveland Clinic at the 2006 Prostate Cancer Symposium in San Francisco, February 24, 2006.

3 May 2006

Environmentally damaged DNA may contribute to human genetic diversity

In this month's issue of the leading scientific journal Genome Research, scientists from Kyushu University report how environmentally damaged DNA may contribute to human genetic diversity.

2 May 2006