Frontotemporal Dementia (FTD) News and Research

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Scientists gain new insight into the pathological mechanisms behind two neurodegenerative diseases

An international team led by Emory scientists has gained insight into the pathological mechanisms behind two devastating neurodegenerative diseases.

6 May 2020

Researchers identify a new risk factor for multiple neurodegenerative diseases

Scientists at the HudsonAlpha Institute for Biotechnology, the University of California, San Francisco (UCSF), and the University of Alabama at Birmingham (UAB), have identified a new risk factor for multiple neurodegenerative diseases.

28 Apr 2020

A physically and mentally active lifestyle can slow familial frontotemporal dementia

A physically and mentally active lifestyle confers resilience to frontotemporal dementia (FTD), even in people whose genetic profile makes the eventual development of the disease virtually inevitable, according to new research by scientists at the UC San Francisco Memory and Aging Center.

8 Jan 2020

Inflammatory processes drive progression of neurodegenerative brain diseases

Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons.

20 Nov 2019

TDP-43 study could speed up the diagnosis and treatment of ALS

A new study suggests that TDP-43 may be used as a biomarker in the diagnosis and treatment of amyotrophic lateral sclerosis (ALS).

30 Oct 2019

Improved antibody validation

Antibodies are used in a variety of clinical and research situations to examine the structure and function, and distribution of proteins. However, many researchers have found a lack of specificity in the functioning of these antibodies. This means that any work conducted using these antibodies will not yield reliable results.

16 Oct 2019

Research reveals increased inflammatory activity in patients with frontotemporal dementia

Recent research from the University of Eastern Finland revealed increased inflammatory activity in a subgroup of patients with frontotemporal dementia. Increased inflammation was associated with parkinsonism symptoms and more rapid disease progression.

15 Oct 2019

How dementia spreads: new study says it’s through neural networks

Scientists have found out a way to forecast the spread of brain atrophy, using prior research that shows how brain networks connect with each other to form a continuously linked pathway.

14 Oct 2019

Dementia spreads via synaptic connections between brain networks

In a new study, UC San Francisco scientists used maps of brain connections to predict how brain atrophy would spread in individual patients with frontotemporal dementia, adding to growing evidence that the loss of brain cells associated with dementia spreads via the synaptic connections between established brain networks.

14 Oct 2019

The delicate issue of taking away a senior’s smartphone

At first, Dr. Robert Zorowitz thought his 83-year-old mother was confused. She couldn't remember passwords to accounts on her computer. She would call and say programs had stopped working.

26 Sep 2019

RNA hitches lysosome rides to make proteins far away from the nucleus

Proteins inside a cell are often made at the site where they are used, rather than being shipped long distances. This is so with nerve cells which have long cell extensions in the form of axons and dendrites, up to four feet long in some case

22 Sep 2019

Study shows marked impairment of moral emotions in patients with frontotemporal dementia

A study conducted by Marc Teichmann and Carole Azuar at the Brain and Spine Institute in Paris (France) and at the Pitié-Salpêtrière Hospital shows a particularly marked impairment of moral emotions in patients with frontotemporal dementia.

16 Jun 2019

Researchers uncover potential clue to halt destruction of nerve cells in people with ALS

A special focus on rogue proteins may hold future promise in stopping the progression of nerve cell destruction in people who have amyotrophic lateral sclerosis or frontotemporal dementia.

24 Apr 2019

Researchers observe correlation between abnormal proteins and aggressive behavior in dementia

Researchers at Lund University in Sweden have together with American colleagues studied deceased patients who were diagnosed with Alzheimer's disease or frontotemporal dementia.

12 Apr 2019

Biochemical switches could be triggered to treat pathology of IBM, ALS and FTD

St. Jude Children's Research Hospital scientists have found that the enzymes ULK1 and ULK2 play a key role in breaking down cell structures called stress granules, whose persistence leads to toxic buildup of proteins that kill muscle and brain cells.

11 Apr 2019

Scientists solve mystery surrounding common genetic cause of ALS

St. Jude Children's Research Hospital scientists have cracked the mystery surrounding the most common genetic cause of amyotrophic lateral sclerosis, or Lou Gehrig's disease.

11 Apr 2019

Scientists develop technique to clear abnormal tau protein from human neurons

Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.

10 Apr 2019