Gene Therapy News and Research

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Gene therapy is an experimental technique that uses genes to treat or prevent disease. In the future, this technique may allow doctors to treat a disorder by inserting a gene into a patient’s cells instead of using drugs or surgery.

Iron nanoparticles exhibit toxic effects on neuronal cells

Researchers at UC San Diego have discovered that iron-containing nanoparticles being tested for use in several biomedical applications can be toxic to nerve cells and interfere with the formation of their signal-transmitting extensions.

1 Apr 2007

Scientists alter electrical properties of cells inducing regeneration

Scientists at Forsyth may have moved one step closer to regenerating human spinal cord tissue by artificially inducing a frog tadpole to re-grow its tail at a stage in its development when it is normally impossible. Using a variety of methods including a kind of gene therapy, the scientists altered the electrical properties of cells thus inducing regeneration.

28 Feb 2007

Gene therapy shows promise as treatment for diseased lower limbs at risk for amputation

New research suggests that gene therapy is a safe treatment method to explore in patients whose lower limbs are at risk for amputation because of poor circulation caused by blocked blood vessels.

27 Feb 2007

Genetically caused deafness may be reversible by compensating for a missing protein

Emory University researchers have found that in mice, increasing the amount of the protein connexin26 in the ear's cochlea compensates for an absence of another protein, connexin30.

26 Feb 2007

siRNA delivery into human T cells and primary cells with carbon-nanotube transporters

A promising approach to gene therapy involves short DNA fragments (interfering RNA) that bind to specific genes and block their "translation" into the corresponding, disease-related protein.

20 Feb 2007

RNAi shows promise in gene therapy

Three years ago Mark Kay, MD, PhD, published the first results showing that a biological phenomenon called RNA interference could be an effective gene therapy technique. Since then he has used RNAi gene therapy to effectively shut down the viruses that cause hepatitis and HIV in mice.

19 Feb 2007

Kaiser Permanente launches long term project to collect genetic data

California-based HMO Kaiser Permanente on Wednesday announced the creation of a decades-long research project that will collect and analyze genetic information from hundreds of thousands of adult members, the San Jose Mercury News reports.

19 Feb 2007

Human proteins evolving slowly thanks to multi-tasking genes

Many human proteins are not as good as they might be because the gene sequences that code for them have a double role which slows down the rate at which they evolve, according to new research published in PLoS Biology.

6 Feb 2007

Nanoparticles yield delivery tools for therapeutic nucleic acids

Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.

16 Jan 2007

New hope for Krabbe disease sufferers

By all expectations, it shouldn't have worked as well as it did. A combination of bone marrow transplantation and gene therapy greatly lengthened the lives of laboratory mice doomed by a rapidly progressing, fatal neurodegenerative disorder also found in people.

9 Jan 2007

Modified skin cells that may help protect cultured skin substitutes from infection

Cincinnati burn researchers have created genetically modified skin cells that, when added to cultured skin substitutes, may help fight off potentially lethal infections in patients with severe burns.

9 Jan 2007

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Though gene therapies hold great promise for treating cancer, it has proven difficult to deliver therapeutic genes efficiently into cancer cells.

18 Dec 2006

Human embryonic stem cells show potential in treating rats with Parkinson's symptoms

Brain cells derived from human embryonic stem cells improved the condition of rats with Parkinson's-like symptoms dramatically, but the treatment caused a significant problem - the appearance of brain tumors - that scientists are now working to solve.

2 Dec 2006

Gene therapy to treat erectile dysfunction shows promise

The first human study using gene transfer to treat erectile dysfunction (ED) shows promising results and suggests the potential for using the technology to treat overactive bladder, irritable bowel syndrome and asthma, according to the researchers.

2 Dec 2006

Nanotechnology continues to advance anticancer gene therapy

Given that cancer is a disease in which genetic errors play a major role, it should come as no surprise that many experts envision a time when gene therapy will play an equally important role in the treatment of cancer.

20 Nov 2006

Researchers use gene therapy to reduce the development of epileptic seizures

For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals. By using gene therapy to modify signaling pathways in the brain, neurology researchers found that they could significantly reduce the development of epileptic seizures in rats.

8 Nov 2006

Phase I clinical trial of experimental gene therapy to treat HIV shows encouraging results

The results of a Phase I clinical trial of an experimental gene therapy aimed at treating HIV indicate that the therapy is safe and effective and also might sustain viral loads, according to a study published on Monday in the online edition of the Proceedings of the National Academy of Sciences, the AP/Washington Post reports.

8 Nov 2006

Further European investment in genomics

The Economic and Social Research Council (ESRC) has announced continued funding, from 2007 to 2012, for its three research centres, CESAGen, EGENIS and INNOGEN, that, along with the ESRC Genomics Policy and Research Forum, make up the ESRC Genomics Network.

23 Oct 2006

FDA approves test to help diagnose HIV

The U.S. Food and Drug Administration (FDA) has approved the APTIMA HIV-1 RNA Qualitative Assay, manufactured by Gen-Probe Incorporated (San Diego, Calif.).

5 Oct 2006

Leptin could combat type 2 diabetes

University of Florida researchers have discovered the appetite-controlling hormone leptin could also combat type 2 diabetes, a disease that has become a growing problem in the United States as more Americans pack on extra pounds.

21 Sep 2006