Genetic Information News and Research

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Five-year, $3.7M trial evaluates customized warfarin dosage based on patient genetics

A five-year, $3.7 million clinical trial will investigate how to balance the benefits and risks of warfarin, a drug that helps prevent potentially deadly blood clots.

9 Apr 2010

Clinical testing service for safer dosing of warfarin

Machaon Diagnostics, California's only independent laboratory for testing bleeding and clotting disorders has launched a clinical testing service for patients that have been prescribed warfarin. Warfarin, also known as Coumadin, Jantoven or warfarin sodium, is a potent 'blood thinner' or anticoagulant.

8 Apr 2010

Blocking POLQ gene activity can increase ability of radiotherapy to destroy tumours

Cancer Research UK scientists have identified a gene that once blocked could increase the effectiveness of radiotherapy on tumours, according to research published in Cancer Research today (Thursday).

7 Apr 2010

DNA patent case: US District Judge rules in favor of AMP

The Association for Molecular Pathology (AMP) is an international medical and professional association representing approximately 1,800 physicians, doctoral scientists, and medical laboratory scientists who perform laboratory testing based on knowledge derived from molecular biology, genetics, and genomics. AMP applauds US District Judge Robert Sweet's ruling in favor of the plaintiffs in the lawsuit, Association for Molecular Pathology, et al. v. U.S. Patent and Trademark Office, et al.

2 Apr 2010

DNA resources coupled to EMR systems hold potential as valuable tools for clinical research

A new study reveals an exciting potential benefit of the rapidly accumulating databases of health care information, the ability to make unprecedented links between genomic data and clinical medicine. The research, published by Cell Press in the April issue of the American Journal of Human Genetics, supports the idea that large scale DNA databanks linked to electronic medical record (EMR) systems provide a valuable platform for discovering, assessing and validating associations between genes and diseases.

2 Apr 2010

Court rules against gene patents

The New York Times: A judicial ruling that "threw out parts of two gene patents and called into question thousands more" has biotechnology executives hastening "to reassure their investors that the ruling would not necessarily undermine their businesses, at least in the short run. But the executives themselves were struggling on Tuesday to figure out what the long-term impact would be."

1 Apr 2010

New research may help advance treatment strategies for common liver disease

A research article published in the journal PloS Pathogens could lead to improvements in the production of vaccines for hepatitis A, the most widespread viral disease in the world.

26 Mar 2010

Celladon Corporation receives USPTO notice of allowance covering MYDICAR for advanced heart failure

Celladon Corp. announced today that the United States Patent and Trademark Office (USPTO) has granted a notice of allowance for a broad patent covering the company's lead drug candidate MYDICAR®, a genetically targeted enzyme replacement therapy for advanced heart failure. The patent will be issued to The Regents of the University of California and licensed exclusively to Celladon.

23 Mar 2010

Caltech-led trial demonstrates feasibility of nanoparticles and RNAi-based therapeutics for treating cancer

A California Institute of Technology -led team of researchers and clinicians has published the first proof that a targeted nanoparticle-used as an experimental therapeutic and injected directly into a patient's bloodstream-can traffic into tumors, deliver double-stranded small interfering RNAs (siRNAs), and turn off an important cancer gene using a mechanism known as RNA interference (RNAi).

22 Mar 2010

Genetic test helps reduce hospitalization rates for heart patients on warfarin

Hospitalization rates for heart patients taking warfarin, the world's most-prescribed blood thinner, dropped by approximately 30 percent when genetic information was available to doctors prescribing the drug, researchers from Medco Health Solutions, Inc.-- in association with the Medco Research Institute™ -- and Mayo Clinic announced today.

17 Mar 2010

Bench to Bassinet Program aims to move lab results into clinical practice

To help speed the translation of scientific discoveries into usable treatments in congenital heart disease, the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health launched the Bench to Bassinet Program.

17 Mar 2010

Illumina sequences DNA of American actress Glenn Close

Illumina, Inc. today announced that it has sequenced the DNA of American actress Glenn Close, the first publicly named female to have her DNA sequenced to full coverage.

From Illumina, Inc. 11 Mar 2010

Whole genome sequencing of entire family beneficial

The Institute for Systems Biology (ISB) has analyzed the first whole genome sequences of a human family of four. The findings of a project funded through a partnership between ISB and the University of Luxembourg was published online today by Science on its Science Express website. It demonstrates the benefit of sequencing entire families, including lowering error rates, identifying rare genetic variants and identifying disease-linked genes.

11 Mar 2010

ISB uses Complete Genomics’ service to sequence genomes of four family members suffer from Miller syndrome

Complete Genomics Inc., a third-generation human genome sequencing company, today announced that the Institute for Systems Biology employed Complete Genomics’ human genome sequencing service to sequence a family quartet to determine the depth of genetic information possible in analyzing a full family’s sequence, and to verify the gene responsible for Miller syndrome, a rare craniofacial disorder.

11 Mar 2010

Scientists identify specific causative genetic mutation associated with CMT

Scientists using advanced genomic analysis technologies from Life Technologies Corporation have sequenced an individual’s genome and identified the specific causative mutation associated with Charcot-Marie-Tooth Disease (CMT), one of the most common inherited neurological disorders currently affecting 1 in 2,500 individuals in the United States.

11 Mar 2010

Genetic epidemiology: Importance of population genomics

Did women and men contribute equally to the lineage of contemporary populations? Did our ancestors, Homo sapiens, lean more toward polygamy or monogamy? To answer these questions, Dr. Damian Labuda, an investigator at the Sainte-Justine University Hospital Research Center and a professor at the Department of Pediatrics of the Universit- de Montr-al, headed a team that analyzed genomic data from three population samples of African, Asian and European origin. The study's findings are published in the most recent issue of the American Journal of Human Genetics.

5 Mar 2010

InterSystems Ensemble platform enables first successful electronic transmission of genetic data

InterSystems Corporation, the global leader in software for connected healthcare, today announced that InterSystems Ensemble® was the software platform for the first-ever successful electronic transmission of comprehensive genetic data. The information was sent cross-country from Boston-based Partners HealthCare Center for Personalized Genetic Medicine (PCPGM) to Intermountain HealthCare in Salt Lake City, Utah. The announcement about reaching this milestone in personalized medicine came at the HIMSS10 conference.

2 Mar 2010

Body repairs itself through microvesicles: New hope for tissue regeneration

Researchers at Rhode Island Hospital have discovered how cells communicate with each other during times of cellular injury. The findings shed new light on how the body repairs itself when organs become diseased, through small particles known as microvesicles, and offers hope for tissue regeneration.

27 Feb 2010

LGL awards first three grants from POC fund for research in immunotherapy, schizophrenia and heart disease

London Genetics Limited, an expert in the use of pharmacogenetics in clinical drug discovery and development, has awarded the first three grants from its proof-of-concept (POC) fund. The awards, to teams at Imperial College London and University College London, are for research in the areas of immunotherapy, schizophrenia and heart disease.

25 Feb 2010

SeqWright deploys Isilon scale-out NAS storage solution for next-generation genomic sequencing services

Isilon® Systems today announced that SeqWright has deployed Isilon scale-out NAS as an end-to-end storage solution for its full range of next-generation genomic sequencing services. By combining Isilon's X-Series, NL-Series and Backup Accelerator, SeqWright has created a comprehensive solution for every stage of its DNA sequencing workflow – from primary storage, to nearline archival, to tape backup – accelerating time-to-results without requiring full-time storage administration.

25 Feb 2010

Genetic Information News and Research

Five-year, $3.7M trial evaluates customized warfarin dosage based on patient genetics

Clinical testing service for safer dosing of warfarin

Blocking POLQ gene activity can increase ability of radiotherapy to destroy tumours

DNA patent case: US District Judge rules in favor of AMP

DNA resources coupled to EMR systems hold potential as valuable tools for clinical research

Court rules against gene patents

New research may help advance treatment strategies for common liver disease

Celladon Corporation receives USPTO notice of allowance covering MYDICAR for advanced heart failure

Caltech-led trial demonstrates feasibility of nanoparticles and RNAi-based therapeutics for treating cancer

Genetic test helps reduce hospitalization rates for heart patients on warfarin

Bench to Bassinet Program aims to move lab results into clinical practice

Illumina sequences DNA of American actress Glenn Close

Whole genome sequencing of entire family beneficial

ISB uses Complete Genomics’ service to sequence genomes of four family members suffer from Miller syndrome

Scientists identify specific causative genetic mutation associated with CMT

Genetic epidemiology: Importance of population genomics

InterSystems Ensemble platform enables first successful electronic transmission of genetic data

Body repairs itself through microvesicles: New hope for tissue regeneration

LGL awards first three grants from POC fund for research in immunotherapy, schizophrenia and heart disease

SeqWright deploys Isilon scale-out NAS storage solution for next-generation genomic sequencing services

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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