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Natural antibiotic produced by bacteria found on African ant could help fight against MRSA

A new antibiotic, produced by bacteria found on a species of African ant, is very potent against antibiotic-resistant 'superbugs' like MRSA according to scientists.

15 Feb 2017

Scientists identify genetic signature of risk for type 2 diabetes

Why do some people get Type 2 diabetes, while others who live the same lifestyle never do? For decades, scientists have tried to solve this mystery - and have found more than 80 tiny DNA differences that seem to raise the risk of the disease in some people, or protect others from the damagingly high levels of blood sugar that are its hallmark.

14 Feb 2017

Genetic proneness to illnesses may contribute to self-reported tiredness and low energy

Already feeling drained so early in the year? Genes might contribute in a small but significant way to whether people report being tired and low in energy.

14 Feb 2017

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

A father's nicotine use may have a significant impact on children's risk of some diseases. In a study published in the online biomedical sciences journal eLife, Oliver J. Rando, MD, PhD, and colleagues at UMass Medical School, demonstrate that mice born of fathers who are habitually exposed to nicotine inherit enhanced chemical tolerance and drug clearance abilities.

14 Feb 2017

Study shows how errors in specific gene can cause growth defects linked to dwarfism

A new study shows how errors in a specific gene can cause growth defects associated with a rare type of dwarfism.

13 Feb 2017

Professor aims to develop shortcuts for targeted and effective cancer therapy

The aim is to identify precisely the one drug, or the correct combination of drugs, that are most effective against the specific tumor present in each patient. Professor hopes that new tools will come into use in the next five years.

13 Feb 2017

MSK researchers publish new review that focuses on genome-driven oncology

Researchers from Memorial Sloan Kettering Cancer Center today published a seminal review of the rapidly evolving field of precision oncology, which allows doctors to recommend therapies based on a genetic understanding of a person's cancer.

9 Feb 2017

Scientists identify gene variants that predispose children to developing Kawasaki disease

Kawasaki disease (KD) is the most common acquired heart disease in children. Untreated, roughly one-quarter of children with KD develop coronary artery aneurysms -- balloon-like bulges of heart vessels -- that may ultimately result in heart attacks, congestive heart failure or sudden death.

9 Feb 2017

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

Investigators at the Medical University of South Carolina report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

8 Feb 2017

NIH researchers identify genes that may predict how melanoma spreads

Cancerous tumors are voracious. Once they have consumed all the oxygen and nutrients in the original tumor site, the cancer cells travel to other parts of the body (metastasize) to find more nourishment.

8 Feb 2017

Geneticists use evolutionary history to shine light on plethora of neurodevelopmental disorders

Geneticists from Trinity College Dublin have used our evolutionary history to shine light on a plethora of neurodevelopmental disorders and diseases.

8 Feb 2017

Researchers uncover reasons for differences between immune cells in males and females

Michigan State University researchers are the first to uncover reasons why a specific type of immune cell acts very differently in females compared to males while under stress, resulting in women being more susceptible to certain diseases.

8 Feb 2017

Study suggests that iPSCs do not develop more mutations than subcloned cells

It's been more than 10 years since Japanese researchers Shinya Yamanaka, M.D., Ph.D., and his graduate student Kazutoshi Takahashi, Ph.D., developed the breakthrough technique to return any adult cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body.

8 Feb 2017

UNC scientists confirm and clarify key molecular details of nucleotide excision repair

Day in and day out, in our bodies, the DNA in cells is damaged for a variety of reasons, and thus intercellular DNA-repair systems are fundamental to the maintenance of life.

8 Feb 2017

Researchers create first animal model of rare disease linked to problem of adrenal glands

The name of the gene is Armc5, for Armadillo repeat containing 5. Until now, its function was unknown. After 10 years of research, a team at the University of Montreal Hospital Research Centrehas succeeded in deleting this gene in experimental mice and discovered that its loss gives rise to a heretofore unidentified syndrome.

7 Feb 2017

Scientists use brain organoids to identify root causes of Miller-Dieker syndrome

Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain "organoids" — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations.

7 Feb 2017

Patients with early, severe depression symptoms have increased genetic risk for psychiatric disorders

Clinical features of major depressive disorder (MDD) may help identify specific subgroups of depressed patients based on associations with genetic risk for major psychiatric disorders, reports a study in Biological Psychiatry.

7 Feb 2017

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

One of the most promising areas of cancer research is personalized therapy using precision medicine. The National Cancer Institute's NCI-MATCH is a large, ongoing clinical trial that matches tumors to therapies based on the tumor's genetic characteristics.

7 Feb 2017

Scientists find new method for identifying therapeutic targets in cancers lacking tumor suppressor genes

A new method has been found for identifying therapeutic targets in cancers lacking specific key tumor suppressor genes.

7 Feb 2017

Scientists evaluate rapid test that detects colistin resistance gene in bacterial isolates

Colistin is used as the "last-resort antibiotic" for dreaded multidrug-resistant pathogens, especially in hospitals. However, gut bacteria that have become insensitive to colistin now exist -- owing to the mobile resistance gene mcr-1. In early 2016, bacteria carrying this resistance gene were detected in Germany for the first time.

6 Feb 2017

Genome News and Research

Natural antibiotic produced by bacteria found on African ant could help fight against MRSA

Scientists identify genetic signature of risk for type 2 diabetes

Genetic proneness to illnesses may contribute to self-reported tiredness and low energy

Children born of fathers exposed to nicotine inherit enhanced chemical tolerance, study shows

Study shows how errors in specific gene can cause growth defects linked to dwarfism

Professor aims to develop shortcuts for targeted and effective cancer therapy

MSK researchers publish new review that focuses on genome-driven oncology

Scientists identify gene variants that predispose children to developing Kawasaki disease

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

NIH researchers identify genes that may predict how melanoma spreads

Geneticists use evolutionary history to shine light on plethora of neurodevelopmental disorders

Researchers uncover reasons for differences between immune cells in males and females

Study suggests that iPSCs do not develop more mutations than subcloned cells

UNC scientists confirm and clarify key molecular details of nucleotide excision repair

Researchers create first animal model of rare disease linked to problem of adrenal glands

Scientists use brain organoids to identify root causes of Miller-Dieker syndrome

Patients with early, severe depression symptoms have increased genetic risk for psychiatric disorders

Next-generation sequencing assay shows accuracy, sensitivity in detecting genetic mutations in tumors

Scientists find new method for identifying therapeutic targets in cancers lacking tumor suppressor genes

Scientists evaluate rapid test that detects colistin resistance gene in bacterial isolates

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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