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p53 and cancer research: an interview with Professor Sir David Lane, Scientific Director of the Ludwig Institute for Cancer Research

P53 is a tumor suppressor gene. The gene encodes for a protein that monitors the state of the cell. If something goes wrong, it stops the cell from dividing or causes the cell to commit suicide. I call it the “guardian of the genome” as it is the molecule that seems to keep cells normal. It is one of our big defenses against cancer.

22 Jul 2013

CLAMP: A newly discovered protein that regulates genes

They say a good man is hard to find. Were it not for a newly discovered protein, the X chromosome of a male fruit fly could never be found by a gene-regulating complex that male flies need to develop and survive. And that case is just one example of what the new finding means. More generally, the research provides biologists with a model of how proteins that govern gene transcription find their targets on chromosomes, a process that's essential to healthy cell function and sometimes implicated in disease.

22 Jul 2013

Investigators report complete catalog of genes expressed in retina

Investigators at Massachusetts Eye and Ear and Harvard Medical School have published the most thorough description of gene expression in the human retina reported to date. In a study published today in the journal BMC Genomics, Drs. Michael Farkas, Eric Pierce and colleagues in the Ocular Genomics Institute at Mass. Eye and Ear reported a complete catalog of the genes expressed in the retina.

20 Jul 2013

NKX2-8 mutation in dogs may be a risk factor for human neural tube defects, say researchers

A gene related to neural tube defects in dogs has for the first time been identified by researchers at the University of California, Davis, and University of Iowa.

20 Jul 2013

Researchers uncover evidence that genetic changes play role in resistance to deadly disease

Researchers have long understood that genetics can play a role in how susceptible people are to contracting cholera, but a team of Harvard scientists is now uncovering evidence of genetic changes that might also help protect some people from contracting the deadly disease.

20 Jul 2013

Researchers demonstrate that 2-drug combination can eliminate cancer

New research conducted by Harvard scientists is laying out a roadmap to one of the holy grails of modern medicine - a cure for cancer.

20 Jul 2013

Metagenomics technique used to recover TB genomes from 215-year old mummy

Researchers at the University of Warwick have recovered tuberculosis (TB) genomes from the lung tissue of a 215-year old mummy using a technique known as metagenomics.

20 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

Study shows CMEs can predict risk of cancer in type 2 diabetes patients

Certain chromosomal abnormalities of the preleukemic type appear to be over-represented in patients with type 2 diabetes (T2D) who are suffering from vascular complications. This finding may provide a partial explanation for the higher rates of cancer-related mortality observed among patients with this type of diabetes.

18 Jul 2013

OGT produces free-to-download whitepaper on targeted resequencing strategies

Oxford Gene Technology, provider of innovative genetics research and biomarker solutions to advance molecular medicine, has produced a new, free-to-download whitepaper titled ‘When to use targeted resequencing — Choosing the right NGS method.’

From Oxford Gene Technology 17 Jul 2013

Researchers seek virus genes that allow animal hepatitis E strains infect humans

X.J. Meng, a University Distinguished Professor at Virginia Tech and a virologist at the Virginia-Maryland Regional College of Veterinary Medicine, has received a four-year, nearly $1.6 million grant from the National Institutes of Health to better understand the genetic elements that allow hepatitis E virus to transfer from animals to people.

17 Jul 2013

Study shows environmental conditions have stronger influence on human microbiome

Environmental conditions have a much stronger influence on the mix of microbes living in various parts of your body than does competition between species. Instead of excluding each other, microbes that fiercely compete for similar resources are more likely to cohabit the same individual.

17 Jul 2013

Some strains of avian H7N9 influenza develop resistance to antiviral drugs

Some strains of the avian H7N9 influenza that emerged in China this year have developed resistance to the only antiviral drugs available to treat the infection, but testing for antiviral resistance can give misleading results, helping hasten the spread of resistant strains.

17 Jul 2013

Dartmouth's professor selected as Kavli Fellow of NAS 2013 for significant contributions to science

Professor Jason H. Moore of Dartmouth's Geisel School of Medicine has been selected as a Kavli Fellow of the National Academy of Sciences (NAS) for 2013. The Kavli program honors young scientists who are considered leaders in their fields and have made significant contributions to science.

17 Jul 2013

Largest data set of cancer-specific genetic variations generated by NCI scientists

Scientists at the National Cancer Institute have generated a data set of cancer-specific genetic variations and are making these data available to the research community, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.

16 Jul 2013

Genome News and Research

p53 and cancer research: an interview with Professor Sir David Lane, Scientific Director of the Ludwig Institute for Cancer Research

CLAMP: A newly discovered protein that regulates genes

Investigators report complete catalog of genes expressed in retina

NKX2-8 mutation in dogs may be a risk factor for human neural tube defects, say researchers

Researchers uncover evidence that genetic changes play role in resistance to deadly disease

Researchers demonstrate that 2-drug combination can eliminate cancer

Metagenomics technique used to recover TB genomes from 215-year old mummy

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Study shows CMEs can predict risk of cancer in type 2 diabetes patients

OGT produces free-to-download whitepaper on targeted resequencing strategies

Researchers seek virus genes that allow animal hepatitis E strains infect humans

Study shows environmental conditions have stronger influence on human microbiome

Some strains of avian H7N9 influenza develop resistance to antiviral drugs

Dartmouth's professor selected as Kavli Fellow of NAS 2013 for significant contributions to science

Largest data set of cancer-specific genetic variations generated by NCI scientists

Researchers develop new test to detect E. coli at food processing facilities

Researchers identify genes that allow animal hepatitis E virus strains to infect humans

CUMC researchers develop new approach to tailor cancer therapy for individual patient

Cranberry consumption may prevent chronic infections

Researchers distinguish viral and bacterial infections in children with fever

Genetics & Genomics - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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