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ESF-UB Conference to concentrate on potentially clinically relevant polymorphisms

Pharmacogenetics started in the fifties with the discovery of primaquine-related haemolysis among glucose-6-phosphate deshydrogenase deficient patients. At the end of the century, it progressively evolved into Pharmacogenomics, investigating simultaneously multiple gene targets till covering the whole genome in relation with altered drug response.

8 Jan 2010

CSHL scientists explain how initiation of DNA replication is coordinated and controlled by kinase proteins

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered how a protein long known to be an essential activator of DNA replication actually triggers this process in cells.

8 Jan 2010

Researchers devise method to pinpoint key genetic variations under positive natural selection that may impact human health

Fossils may provide tantalizing clues to human history but they also lack some vital information, such as revealing which pieces of human DNA have been favored by evolution because they confer beneficial traits - resistance to infection or the ability to digest milk, for example. These signs can only be revealed through genetic studies of modern humans and other related species, though the task has proven difficult.

8 Jan 2010

New genetic findings may lead to better interventional therapies for obsessive compulsive disorders

A collaboration between the University of Massachusetts Medical School, the Cummings School of Veterinary Medicine at Tufts University and the Broad Institute at the Massachusetts Institute of Technology has identified a genetic locus on canine chromosome 7 which coincides with an increased risk of obsessive compulsive disorder (OCD) susceptibility.

7 Jan 2010

Mutations in genome regulation machinery identified in clear cell renal cell carcinoma

In a new study, scientists have searched for mutations in the gene regions of more than 100 kidney cancer samples, the largest number of samples from a single tumour type to be sequenced to date.

7 Jan 2010

Protein complex proves valuable for changing cell fate

The DNA contained within each of our cells is exactly the same, yet different types of cells - skin cells, heart cells, brain cells - perform very different functions. The ultimate fate of these cells is encoded not just in the DNA, but in a specific pattern of chemical modifications that overlay the DNA structure.

7 Jan 2010

CSHL scientist discovers how bookmarking protein triggers leukemia

Each cell inherits genes from its parent as well as epigenetic information - what amounts to an instruction manual that specifies which genes should be activated or "expressed," when and to what level.

6 Jan 2010

Agilent Technologies, Covaris sign co-marketing agreement to streamline next-generation sequencing experiments

Agilent Technologies, Inc. (NYSE:A) and Covaris Inc. today announced a co-marketing agreement in which Covaris S2 DNA shearing technology will be marketed with the Agilent SureSelect Target Enrichment System to streamline next-generation sequencing experiments.

6 Jan 2010

Genetic rogue elements could help diagnose breast and bowel cancer

Scientists at The University of Nottingham have found that a group of genetic rogue elements, produced by DNA sequences commonly known as 'junk DNA', could help diagnose breast and bowel cancer.

5 Jan 2010

Carbon nanotube: A viable alternative for rapid DNA sequencing

Faster sequencing of DNA holds enormous potential for biology and medicine, particularly for personalized diagnosis and customized treatment based on each individual's genomic makeup.

4 Jan 2010

Research may point to more effective therapeutic targets for prion diseases

Scientists from The Scripps Research Institute have determined for the first time that prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, are capable of Darwinian evolution.

4 Jan 2010

US-German team studies genome mutations

"While the long term effects of genome mutations are quite well understood, we did not know how often new mutations arise in the first place," said Detlef Weigel, director at the Max Planck Institute in Germany. It is routine today to compare the genomes of related animal or plant species.

3 Jan 2010

Scientists discover a new family of giant virus

After Mimivirus, Mamavirus and the virophage, the group of giant viruses now has a new member called Marseillevirus. Discovered in an amoeba by the team led by Didier Raoult at the Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes research group (CNRS/Université Aix-Marseille 2), a description of this new virus was published this week on the website of the Proceedings of the National Academy of Sciences (PNAS).

31 Dec 2009

Presence of Streptococcus pneumoniae could predict risk of severe disease in H1N1 pandemic influenza

The presence of the Streptococcus pneumoniae in samples that can be easily obtained in clinics and emergency rooms may predict risk of severe disease in H1N1 pandemic influenza.

31 Dec 2009

Gene mutation that decreases flesh-eating disease discovered by scientists

Scientists at The Methodist Hospital Research Institute in Houston recently discovered a simple gene mutation that decreases the chance people will get a flesh-eating disease called necrotizing fasciitis. Further, they proved that inactivating this section of the gene lessens the devastating disease in humans.

30 Dec 2009

Genome News and Research

ESF-UB Conference to concentrate on potentially clinically relevant polymorphisms

CSHL scientists explain how initiation of DNA replication is coordinated and controlled by kinase proteins

Researchers devise method to pinpoint key genetic variations under positive natural selection that may impact human health

New genetic findings may lead to better interventional therapies for obsessive compulsive disorders

Mutations in genome regulation machinery identified in clear cell renal cell carcinoma

Protein complex proves valuable for changing cell fate

CSHL scientist discovers how bookmarking protein triggers leukemia

Agilent Technologies, Covaris sign co-marketing agreement to streamline next-generation sequencing experiments

Genetic rogue elements could help diagnose breast and bowel cancer

Carbon nanotube: A viable alternative for rapid DNA sequencing

Research may point to more effective therapeutic targets for prion diseases

US-German team studies genome mutations

Scientists discover a new family of giant virus

Presence of Streptococcus pneumoniae could predict risk of severe disease in H1N1 pandemic influenza

Gene mutation that decreases flesh-eating disease discovered by scientists

Scientists identify new gene variants associated with disturbances in lipid metabolism

Highlights from Mayo Clinic's Discovery's Edge research magazine

Study reveals genomic switches separate autoimmune disorders in different clusters

Researchers unveil complete genetic make-up of cavity-causing bacterium

Discovery enables scientists to devise novel strategies to diagnose and treat brain cancer

Genetics & Genomics - Second Edition eBook

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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