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Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Researchers developed an engineered transcriptional repressor that durably silences the Pcsk9 gene in mice, reducing cholesterol levels for up to a year with a single treatment, showcasing a potential breakthrough in genetic disorder treatments without the risks of DNA mutation.

29 Feb 2024

Breakthrough CRISPR technique unlocks insights about cancer immunology

Over the past two decades, the immune system has attracted increasing attention for its role in fighting cancer.

29 Feb 2024

H5N1 variant spreads between species, endangering wildlife

The highly pathogenic avian influenza virus H5N1 has adapted to spread between birds and marine mammals, posing an immediate threat to wildlife conservation, according to a study from the University of California, Davis, and the National Institute of Agricultural Technology (INTA) in Argentina.

29 Feb 2024

GTF2I gene's role in Williams syndrome and autism unraveled

Individuals with the neurodevelopmental disorder Williams syndrome have a gregarious "cocktail party" personality, while those with the opposite genetic alteration, in contrast, tend to have autistic traits and are prone to struggle socially.

28 Feb 2024

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Scientists at EPFL uncover the mechanism by which cells mark the protein cGAS for degradation, which is critical in preventing the immune system from mistakenly attacking the body's own tissues.

28 Feb 2024

Developing a prognostic model for bladder urothelial cancer using oxidative stress signatures

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, "Prognostic model development and molecular subtypes identification in bladder urothelial cancer by oxidative stress signatures."

28 Feb 2024

Research identifies genetic change associated with human tail loss

A genetic change in our ancient ancestors may partly explain why humans don't have tails like monkeys, finds a new study led by researchers at NYU Grossman School of Medicine.

28 Feb 2024

Genetic risk tool could aid early diagnosis and treatment of multiple sclerosis patients

Young people could be spared from going blind by a new genetic risk tool that could also help diagnose multiple sclerosis (MS) earlier, to start effective treatments.

28 Feb 2024

How can food influence the severity of menopausal hot flashes?

Mechanisms and nutrients related to menopause hot flashes.

28 Feb 2024

Caffeine's protective effects against obesity and joint diseases supported by genetic study

The effects of caffeine levels in circulation by considering genetically predicted variations in caffeine metabolism.

28 Feb 2024

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

Genetic variant research in hypertension has identified numerous associations but is unlikely to yield new treatments, emphasizing the gap between scientific discovery and clinical application.

27 Feb 2024

SickKids scientists lay the groundwork for early detection of cardiomyopathy

In the first study to use whole genome sequencing to examine tandem repeat expansions in heart conditions, scientists at The Hospital for Sick Children (SickKids) have laid the groundwork for early detection of and future precision therapies for cardiomyopathy.

27 Feb 2024

Study shows the benefits of locally administered intranasal live-attenuated SARS-CoV-2 vaccine

Rocketvax AG, together with the German Research Foundation (DFG), has financially supported a study carried out as part of a joint project of the Swiss National Science Foundation (SNSF, National Research Program "Covid-19," NRP 78) and the German Research Foundation (DFG) "Recoding the SARS-CoV-2 Genome - A Multidisciplinary Approach to Generate Live-Attenuated Coronavirus Vaccines."

27 Feb 2024

Breakthrough research could transform the landscape of ovarian cancer treatment

In a major scientific breakthrough, newly published research from an international consortium led by the University of Minnesota's Masonic Cancer Center has the potential to transform the landscape of ovarian cancer treatment.

27 Feb 2024

FB1006: AI-discovered drug advances to clinical trials for ALS treatment

Amyotrophic Lateral Sclerosis (ALS) is a fatal type of motor neuron disease characterized by progressive degeneration of nerve cells in the spinal cord and brain, resulting in muscle weakness and paralysis that can include the inability to walk and speak, or even swallow and breathe.

27 Feb 2024

Bio-Rad launches vericheck ddPCR replication competent lentivirus and replication competent AAV kits for cell and gene therapy production

Rapid, Sensitive, and Validated Detection of Viral Replication Genes Using Droplet Digital™ PCR During Cell and Gene Therapy Production.

From Bio-Rad Laboratories 27 Feb 2024

Tea consumption increases bone density and reduces the risk of osteoporosis

The causal relationship between tea consumption and total-body (TB) bone mineral density (BMD).

27 Feb 2024

Mapping the brain: How cell types and location influence Parkinson’s disease

A single-cell spatial transcriptome analysis on murine brain expression in age and disease using a Parkinson's disease.

27 Feb 2024

Ultima announces UG 100™ and reveals disruptive cost and accuracy profile to enable the era of the $100 genome and beyond

Today, the Company is also introducing ppmSeqTM, a disruptive new mode for extreme raw read accuracy in calling single nucleotide variants (SNVs). ppmSeqTM is a new proprietary feature enabled by Ultima’s unique approach that dramatically improves the raw read accuracy of calling SNVs by removing sample errors introduced upstream of the sequencing workflow.

From Ultima Genomics, Inc. 26 Feb 2024

Study sheds light on the composition of nuclear matrix in Arabidopsis thaliana

Chromatin is a unique DNA and protein complex that makes up the chromosomes. Specific proteins (histones) wind up the DNA like small cable drums to package the long DNA.

23 Feb 2024

Genome News and Research

Breakthrough gene silencing method slashes cholesterol for a year in mice, no DNA damage

Breakthrough CRISPR technique unlocks insights about cancer immunology

H5N1 variant spreads between species, endangering wildlife

GTF2I gene's role in Williams syndrome and autism unraveled

EPFL scientists uncover protein degradation mechanism preventing autoimmune reactions

Developing a prognostic model for bladder urothelial cancer using oxidative stress signatures

Research identifies genetic change associated with human tail loss

Genetic risk tool could aid early diagnosis and treatment of multiple sclerosis patients

How can food influence the severity of menopausal hot flashes?

Caffeine's protective effects against obesity and joint diseases supported by genetic study

Genetic studies shed light on hypertension risk but fall short of revealing new treatments

SickKids scientists lay the groundwork for early detection of cardiomyopathy

Study shows the benefits of locally administered intranasal live-attenuated SARS-CoV-2 vaccine

Breakthrough research could transform the landscape of ovarian cancer treatment

FB1006: AI-discovered drug advances to clinical trials for ALS treatment

Bio-Rad launches vericheck ddPCR replication competent lentivirus and replication competent AAV kits for cell and gene therapy production

Tea consumption increases bone density and reduces the risk of osteoporosis

Mapping the brain: How cell types and location influence Parkinson’s disease

Ultima announces UG 100™ and reveals disruptive cost and accuracy profile to enable the era of the $100 genome and beyond

Study sheds light on the composition of nuclear matrix in Arabidopsis thaliana

Genetics & Genomics - Second Edition eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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