Tea consumption increases bone density and reduces the risk of osteoporosis

NewsGuard 100/100 Score

In a recent study published in Frontiers in Nutrition, researchers assessed the causal relationship between tea consumption and total-body (TB) bone mineral density (BMD).

Study: Tea intake and total body bone mineral density of all ages: a Mendelian randomization analysis. Image Credit: Wiro.Klyngz/Shutterstock.comStudy: Tea intake and total body bone mineral density of all ages: a Mendelian randomization analysis. Image Credit: Wiro.Klyngz/Shutterstock.com

Background

BMD is an indicator of bone strength and a crucial measure of osteoporosis examination. Osteoporosis risk has been increasing with the aging global population, and it represents a significant public health concern.

Osteoporosis strongly correlates with age and gender, influenced by body mass index (BMI), race, lifestyle choices, and height.

The relationship between BMD and tea intake has been debatable. Previously, it was considered that tea consumption may result in calcium loss, contributing to osteoporosis; this stemmed from the notion that caffeine present in tea may impair calcium absorption and elevate its elimination through urine. However, tea composition is more complex than coffee, and its effects on bone density may vary.

By contrast, increasing evidence from observational studies indicates that tea intake does not contribute to calcium loss and bone density reduction.

Numerous studies have underscored the benefits of tea in bone density improvement and osteoporosis prevention.

Nevertheless, establishing conclusive evidence from observational research is challenging, and the causal link between tea and bone density remains undetermined.

About the study

The present study examined the causal relationship between tea consumption and TB-BMD using Mendelian randomization (MR) analysis. Data were obtained from reliable sources based on comprehensive genome-wide association studies (GWASs).

In particular, summary data on tea consumption and TB-BMD were obtained from the Integrative Epidemiology Unit (IEU) OpenGWAS project.

Tea intake data were secured from the United Kingdom (UK) Biobank. The Medical Research Council (MRC) IEU obtained data on herbal and green tea consumption.

TB-BMD dataset was obtained from a meta-analysis of 30 GWASs with > 56,000 individuals. BMD t-scores were used to identify individuals with osteoporosis or osteopenia, per the World Health Organization (WHO) criteria.

Instrumental variables (IVs) were single nucleotide polymorphisms (SNPs) associated with tea consumption at genome-wide significance. The PhenoScanner database was utilized to identify genetic variants associated with potential confounders.

Outcome data related to retained SNPs were extracted. Datasets were harmonized by excluding ambiguous and palindromic SNPs with non-concordant alleles to ensure consistency between exposure and outcomes.

A two-sample MR analysis assessed the causal association between genetically predicted tea consumption and TB-BMD, using methods like MR-Egger, simple or weighted mode, inverse-variance weighted (IVW), and weighted median.

Pleiotropy effects were identified/addressed using MR-regression and MR-pleiotropy residual sum and outlier (PRESSO) methods. A leave-one-out sensitivity analysis examined how individual SNPs impact the overall causal effect.

Findings

Overall, 41 SNPs were retained as IVs for tea consumption following the exclusion of SNPs with linkage disequilibrium.

The primary analytical method, IVW, showed a causal association between genetically predicted tea consumption and TB-BMD, particularly in the 45–60 age group.

However, this was not observed in other age groups (people aged ≤45 or ≥ 60). Other methods (simple or weighted mode, weighted median, and MR-Egger) showed concordant outcomes.

There was no significant heterogeneity between TB-BMD and tea intake; the lack of heterogeneity was consistent in the 45–60 age group. There was no evidence of directional pleiotropy, including in the 45–60 age group.

The sensitivity analysis revealed that the observed causal relationship was not driven by any individual SNP. Finally, there was no causal relationship between herbal or green tea intake and TB-BMD.  

Conclusions

To summarize, the research team performed an MR analysis to investigate the causal effects of tea consumption on BMD.

The findings suggest that people with a greater genetic predisposition to consume increased quantities of tea were likelier to have higher BMD. Notably, the study exclusively included individuals of European ancestry, and MR outcomes vary by ethnicity.

Further, MR analyses cannot exhaustively rule out unknown/hidden confounders and only provide statistical evidence. Together, the results illustrate that a genetic predisposition to tea consumption was associated with improved BMD.

As such, moderate tea consumption may not warrant concerns about calcium loss or osteoporosis. Future studies with larger samples must corroborate the causal relationship and explore the underlying biological mechanisms.

Journal reference:
Tarun Sai Lomte

Written by

Tarun Sai Lomte

Tarun is a writer based in Hyderabad, India. He has a Master’s degree in Biotechnology from the University of Hyderabad and is enthusiastic about scientific research. He enjoys reading research papers and literature reviews and is passionate about writing.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Sai Lomte, Tarun. (2024, February 27). Tea consumption increases bone density and reduces the risk of osteoporosis. News-Medical. Retrieved on April 22, 2024 from https://www.news-medical.net/news/20240227/Tea-consumption-increases-bone-density-and-reduces-the-risk-of-osteoporosis.aspx.

  • MLA

    Sai Lomte, Tarun. "Tea consumption increases bone density and reduces the risk of osteoporosis". News-Medical. 22 April 2024. <https://www.news-medical.net/news/20240227/Tea-consumption-increases-bone-density-and-reduces-the-risk-of-osteoporosis.aspx>.

  • Chicago

    Sai Lomte, Tarun. "Tea consumption increases bone density and reduces the risk of osteoporosis". News-Medical. https://www.news-medical.net/news/20240227/Tea-consumption-increases-bone-density-and-reduces-the-risk-of-osteoporosis.aspx. (accessed April 22, 2024).

  • Harvard

    Sai Lomte, Tarun. 2024. Tea consumption increases bone density and reduces the risk of osteoporosis. News-Medical, viewed 22 April 2024, https://www.news-medical.net/news/20240227/Tea-consumption-increases-bone-density-and-reduces-the-risk-of-osteoporosis.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
Green tea does not lower the risk of lung cancer