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Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* pre-print server, researchers in the United States described a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-neutralizing monoclonal antibody (mAb) SP1-77 that broadly neutralized its multiple variants of concern (VOCs).

28 Jun 2022

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Researchers constructed a full-length SARS-CoV-2 spike structure in its membrane-bound state to study functionally relevant aspects of its global conformational dynamics.

27 Jun 2022

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

Of the three groups of rotavirus that cause gastroenteritis in people, called groups A, B and C, groups A and C affect mostly children and are the best characterized.

9 Jun 2022

MIT researchers identify components of mucus that can inhibit fungal infections

Candida albicans is a yeast that often lives in the human digestive tract and mouth, as well as urinary and reproductive organs.

6 Jun 2022

The pineapple-derived jacalin-related lectin as a potential anti-SARS-CoV-2 agent

Scientists demonstrated that the pineapple-derived jacalin-related lectin (AcmJRL/AnLec) could be an anti-SARS-CoV-2 agent.

31 May 2022

SARS-CoV-2 variants BA.4 and BA.5 show substantial immune escape compared with BA.1 and BA.2

In a recent study posted to the bioRxiv* pre-print server, researchers characterized the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Omicron’s new sub-lineages, BA.4, BA.5, and BA.3.

26 May 2022

A sugar-studded protein could be key to stopping Alzheimer’s disease progression, finds study

In a bit of "reverse engineering" research using brain tissues from five people who died with Alzheimer's disease, Johns Hopkins Medicine researchers say they discovered that a special sugar molecule could play a key role in the development of Alzheimer's disease.

25 May 2022

Researchers explore broad-based immunity against potentially pandemic-causing viruses

A new study focused on broad-spectrum immunity against viruses that harbor the potential for generating a pandemic involving humans, especially those with the potential for zoonotic spillover.

17 May 2022

Infection with SARS-CoV-2 results in antibodies against common colds

A study published in the journal Science Advances uses electron microscopy-based polyclonal epitope mapping (EMPEM) methodology to elucidate the spike epitopes of β-HCoV targeted by preexisting serum antibodies and compares them to the epitopes targeted by antibodies elicited by SARS-CoV-2 infection using electron microscopy-based polyclonal epitope mapping (EMPEM) methodology.

8 May 2022

Researchers investigate O-glycosylation in cells infected with Ebola

Researchers from the Copenhagen Center for Glycomics have been investigating O-glycosylation in cells infected with Ebola virus in order to better understand the disease.

28 Apr 2022

Study investigates the production of a virosome-based COVID-19 vaccine candidate

In a new study, different signal peptides, baculovirus transfer vectors, cell lines, infection techniques, and formulation buffers were investigated with the purpose of building a scalable bioprocess to generate high-quality S protein for incorporation in a virosome-based COVID-19 vaccine candidate.

18 Apr 2022

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

Researchers identified an ultralong bovine antibody that neutralizes SARS-CoV-2 and SARS-CoV.

11 Apr 2022

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

In a recent article published in the journal Proceedings of the National Academy of Sciences (PNAS), researchers reviewed the present-day therapeutic landscape of coronavirus disease 2019 (COVID-19) and addressed future opportunities to overcome challenges that hinder drug development and improve the global preparedness for future pandemics.

10 Apr 2022

Therapeutic antibodies against filoviruses including Ebola and Marburg

Researchers discuss the development and structural characterization of therapeutic monoclonal antibodies targeting the surface glycoprotein of filoviruses.

31 Mar 2022

MERS-CoV-related viruses invade host cells via bat angiotensin-converting enzyme 2 receptors

A recent study discovered that near relatives of MERS-CoV utilize ACE2 as functional receptors.

31 Mar 2022

IgG Fc glycosylation: A marker for severe COVID-19

Researchers suggest that low anti-spike IgG1 glycosylation, sialyation, and high bisection are markers of severe COVID-19.

24 Mar 2022

$Study finds fractionation of sulfated galactan from red alga can isolate its anti-SARS-CoV-2 properties$

Glycan News and Research

Potent antibody with a novel neutralization mechanism against SARS-CoV-2 variants

A full model of the SARS-CoV-2 spike protein for studying its atomic-level dynamics by multiple microsecond simulations

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

MIT researchers identify components of mucus that can inhibit fungal infections

The pineapple-derived jacalin-related lectin as a potential anti-SARS-CoV-2 agent

SARS-CoV-2 variants BA.4 and BA.5 show substantial immune escape compared with BA.1 and BA.2

A sugar-studded protein could be key to stopping Alzheimer’s disease progression, finds study

Researchers explore broad-based immunity against potentially pandemic-causing viruses

Infection with SARS-CoV-2 results in antibodies against common colds

Researchers investigate O-glycosylation in cells infected with Ebola

Study investigates the production of a virosome-based COVID-19 vaccine candidate

Ultralong bovine antibody targets cryptic and conserved epitope on SARS-CoV and SARS-CoV-2

Challenges, unmet needs and future opportunities in COVID-19 therapeutics

Therapeutic antibodies against filoviruses including Ebola and Marburg

MERS-CoV-related viruses invade host cells via bat angiotensin-converting enzyme 2 receptors

IgG Fc glycosylation: A marker for severe COVID-19

Study finds fractionation of sulfated galactan from red alga can isolate its anti-SARS-CoV-2 properties

Conformational variation of the SARS-CoV-2 energy landscape

Engineered SARS-CoV-2 immunogens elicit broadly neutralizing antibodies

Study reveals differential blood glycoprotein profiles in symptomatic and asymptomatic COVID-19 patients

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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