Glycosylation News and Research

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Synthetic mucins shed light on cancer biology and tumor formation

During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health.

18 Mar 2024

Sugar coatings on immunoglobulin G directly related to cardiovascular disease risk

When people hear about predicting heart disease, most will think of cholesterol levels. While cholesterol is a major contributor to heart disease, a recent study from Brigham and Women's Hospital, a founding member of Mass General Brigham, found that a glycan biomarker of IgG is also an important predictor for cardiovascular diseases (CVD).

23 Feb 2024

Largest genetic study on circulating retinol reveals new insights into its impact on health

Study presents the largest genome-wide association analysis on circulating retinol, identifying genes beyond the primary transport system that influence retinol levels and its broad impacts on health, including potential protective roles against schizophrenia and effects on various clinical phenotypes.

21 Feb 2024

New study reveals flaws in AI tools used for SARS-CoV-2 antibody discovery

A discovery program for SARS-CoV-2-nABs potentially targeting its resistant strains.

19 Jan 2024

Study maps gene network orchestrating complex process of IgG glycosylation in aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 24, entitled, "Mapping of the gene network that regulates glycan clock of ageing."

3 Jan 2024

Researchers receive $2 million NSF grant to continue fight against airborne pathogens

Bahareh Behkam and collaborators have received a $2 million grant from the National Science Foundation (NSF) to continue their fight against airborne pathogens

6 Dec 2023

Study unravels how bacterial vaginosis disrupts vaginal health

Bacterial vaginosis is a common condition in which the natural microbiome of the vagina falls out of balance, sometimes leading to complications in sexual and reproductive health.

29 Nov 2023

Novel urine-based prognostic model promises to transform bladder cancer treatment

In a study published in the journal Genes & Diseases, researchers from Fudan University, have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.

21 Nov 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Located in the mucus layer that lines the gastrointestinal tract, mucins-;proteins with attached sugar molecules-;play a key role in combating bacterial infection and providing a safe haven to friendly gut bacteria through unknown mechanisms.

11 Oct 2023

Eat by the clock: How meal timing tunes your liver's circadian rhythm

A study in Nature Communications delves into how the liver's circadian clock responds to meal timing, impacting fat metabolism and other bodily processes. The research underscores the intricate network that contributes to liver's diurnal rhythms, regulated by protein phosphorylation and nutrient availability.

2 Oct 2023

Zoonotic spillover safeguarding: computationally designed antigen targets range of coronaviruses

Researchers used an interdisciplinary approach incorporating phylogenetics, 3D protein modeling, and plasmid design to identify and computationally design an antigen representing the core of most currently known sarbecoviruses.

27 Sep 2023

Innovations in baculovirus–insect cell expression systems

The baculovirus–insect cell expression system—insect cells used in conjunction with the baculovirus expression vector system (BEVS)— remains a crucial technology for manufacturing large and complex proteins. This eukaryotic expression system offers inherent safety, ease of scale-up, flexible product design, and versatility for a broad range of proteins.

From Sino Biological Inc. 20 Sep 2023

Unlocking the power of lectins: BOA emerges as a potent weapon against all SARS-CoV-2 variants

Researchers discover that antiviral lectins like BOA can effectively inhibit SARS-CoV-2 and its variants by targeting spike glycans, opening doors for potential pan-coronavirus treatments. The study reveals that BOA's multivalent interactions make it a potent inhibitor against a range of viral variants, offering promise for future therapeutic strategies.

14 Sep 2023

Study characterizes SARS-CoV-2 Omicron BA.2.86: New variant under watch

Researchers identify a new SARS-CoV-2 variant, BA.2.86, with enhanced ability to evade immunity but lower infectivity compared to current variants. The study highlights the need for global monitoring due to its potential to become a predominant strain if it gains infectivity through mutations.

6 Sep 2023

Scientists develop new technique to study sugars on immune cells

Everyone loves a sweet treat, even our cells. While we typically think of sugar as a component of our diet that gives us energy, sugars are also very important in guiding the activity of our cells.

5 Sep 2023

Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetes

A recent study in the Journal of Biomedical Science examines the critical role of ACE2, an enzyme involved in blood volume and electrolyte balance, in chronic diseases like cardiovascular conditions, diabetes, and COVID-19. The research suggests that ACE2 could serve as both a disease severity biomarker and a therapeutic target.

28 Aug 2023