Glycosylation News and Research

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16 promising postdoctoral scientists awarded Damon Runyon Fellowships for cancer research

The Damon Runyon Cancer Research Foundation has named 16 new Damon Runyon Fellows, exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

28 Aug 2024

The surprising role of RNA in immune interactions

In a groundbreaking exploration of cell surface biology, Ryan Flynn has uncovered a surprising role for RNA outside the confines of the cell. Flynn's research, which focuses on the biology of cell surface RNA, led to the discovery that certain RNAs are chemically linked to glycans-;complex carbohydrate polymers found on the cell surface.

22 Aug 2024

New diagnostic method enhances early detection of pancreatic cancer

Pancreatic cancer is one of the most lethal forms of cancer, primarily because it is usually diagnosed very late.

9 Aug 2024

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

In this interview conducted at Pittcon 2024, we spoke to Professor John Yates about capturing cardiomyocyte cell-to-cell heterogeneity via shotgun top-down proteomics.

From Pittcon 6 Aug 2024

Wildlife species show high SARS-CoV-2 exposure linked to human activity

Researchers found SARS-CoV-2 RNA in six wildlife species and higher seroprevalence in high human activity areas. Seven new human-to-animal transmission events of the Omicron variant were identified.

30 Jul 2024

New strategy targets rare B cells for effective HIV vaccine development

Germline-targeting epitope scaffold nanoparticles elicit rare broadly neutralizing antibody (bnAb) precursors against human immunodeficiency virus (HIV).

3 Jun 2024

FAU researchers receive grants to tackle Alzheimer's disease

Three Florida Atlantic University researchers at the forefront of Alzheimer's disease (AD) research have each received a $350,000 grant from the Florida Department of Health's "Ed and Ethel Moore Alzheimer's Disease Research Program."

8 May 2024

New Quartet nanocage vaccine shows promise against coronavirus variants

Researchers have developed a novel vaccination approach using Quartet nanocages that display receptor-binding domains (RBDs) from different sarbecoviruses, showing enhanced immune responses and potential protection against diverse coronavirus strains including SARS-CoV-2 and its variants.

8 May 2024

New blood test shows promise in early detection of ovarian cancer

A study reveals that glycoproteins in blood could be key biomarkers for early detection and staging of epithelial ovarian cancer, potentially allowing diagnosis through a simple blood test.

28 Apr 2024

Synthetic mucins shed light on cancer biology and tumor formation

During cold and flu season, excess mucus is a common, unpleasant symptom of illness, but the slippery substance is essential to human health.

18 Mar 2024

Sugar coatings on immunoglobulin G directly related to cardiovascular disease risk

When people hear about predicting heart disease, most will think of cholesterol levels. While cholesterol is a major contributor to heart disease, a recent study from Brigham and Women's Hospital, a founding member of Mass General Brigham, found that a glycan biomarker of IgG is also an important predictor for cardiovascular diseases (CVD).

23 Feb 2024

Largest genetic study on circulating retinol reveals new insights into its impact on health

Study presents the largest genome-wide association analysis on circulating retinol, identifying genes beyond the primary transport system that influence retinol levels and its broad impacts on health, including potential protective roles against schizophrenia and effects on various clinical phenotypes.

21 Feb 2024

New study reveals flaws in AI tools used for SARS-CoV-2 antibody discovery

A discovery program for SARS-CoV-2-nABs potentially targeting its resistant strains.

19 Jan 2024

Study maps gene network orchestrating complex process of IgG glycosylation in aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 24, entitled, "Mapping of the gene network that regulates glycan clock of ageing."

3 Jan 2024

Researchers receive $2 million NSF grant to continue fight against airborne pathogens

Bahareh Behkam and collaborators have received a $2 million grant from the National Science Foundation (NSF) to continue their fight against airborne pathogens

6 Dec 2023

Study unravels how bacterial vaginosis disrupts vaginal health

Bacterial vaginosis is a common condition in which the natural microbiome of the vagina falls out of balance, sometimes leading to complications in sexual and reproductive health.

29 Nov 2023

Novel urine-based prognostic model promises to transform bladder cancer treatment

In a study published in the journal Genes & Diseases, researchers from Fudan University, have developed a novel urine-based prognostic model that promises to transform the management and treatment of bladder cancer.

21 Nov 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Located in the mucus layer that lines the gastrointestinal tract, mucins-;proteins with attached sugar molecules-;play a key role in combating bacterial infection and providing a safe haven to friendly gut bacteria through unknown mechanisms.

11 Oct 2023

Eat by the clock: How meal timing tunes your liver's circadian rhythm

A study in Nature Communications delves into how the liver's circadian clock responds to meal timing, impacting fat metabolism and other bodily processes. The research underscores the intricate network that contributes to liver's diurnal rhythms, regulated by protein phosphorylation and nutrient availability.

2 Oct 2023