H1N1 News and Research

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Novel influenza A (H1N1) is a new flu virus of swine origin that was first detected in Mexico and the United States in March and April, 2009. The first novel H1N1 patient in the United States was confirmed by laboratory testing at CDC on April 15, 2009. The second patient was confirmed on April 17, 2009. It was quickly determined that the virus was spreading from person-to-person. On April 22, CDC activated its Emergency Operations Center to better coordinate the public health response. On April 26, 2009, the United States Government declared a public health emergency.

It’s thought that novel influenza A (H1N1) flu spreads in the same way that regular seasonal influenza viruses spread; mainly through the coughs and sneezes of people who are sick with the virus.

Researchers look at how the host reacts to a flu virus infection

"Where there are many scientific works dealing solely with the flu virus, we have investigated how the host reacts to an infection," says Klaus Schughart, head of the Experimental Mouse Genetics research group.

29 Mar 2009

Influenza A's resistance to drug Tamiflu increasing

Influenza A viruses (H1N1 subtype) that are resistant to the drug oseltamivir circulated widely in the U.S. during the 2007-2008 influenza season, with an even higher prevalence of drug resistance during the current 2008-2009 influenza season, according to a study to be published in the March 11 issue of JAMA, the Journal of the American Medical Association.

2 Mar 2009

Oseltamivir-resistant influenza A virus potentially serious to high-risk patients

A mutation of the influenza A(H1N1) virus that is resistant to the drug oseltamivir may pose a serious health threat to hospitalized patients who have a weakened immune system, according to a study to be published in the March 11 issue of JAMA, the Journal of the American Medical Association, and being released early online because of its public health importance.

2 Mar 2009

Scientists identify lab-made proteins that neutralize a broad range of influenza A viruses

Scientists have identified a small family of lab-made proteins that neutralize a broad range of influenza A viruses, including the H5N1 avian virus, the 1918 pandemic influenza virus and seasonal H1N1 flu viruses.

23 Feb 2009

Scientists identify lab-made proteins that neutralize multiple strains of seasonal and pandemic flu

22 Feb 2009

Scientists identify human monoclonal antibodies effective against bird flu

Researchers at the Dana-Farber Cancer Institute (Dana-Farber), Burnham Institute for Medical Research (Burnham) and the Centers for Disease Control and Prevention (CDC) have reported the identification of human monoclonal antibodies (mAb) that neutralize an unprecedented range of influenza A viruses, including avian influenza A (H5N1) virus, previous pandemic influenza viruses, and some seasonal influenza viruses.

22 Feb 2009

GlaxoSmithKline ready to supply Biota's Relenza to meet CDC recommendations

GlaxoSmithKline (GSK) is prepared to respond to public health needs for Relenza (zanamivir) Inhalation Powder this flu season following a Health Alert Advisory issued by the Centers for Disease Control and Prevention (CDC).

21 Dec 2008

Novavax announces positive results in trial of seasonal influenza VLP (trivalent) vaccine candidate

Novavax, Inc. has announced favorable results from a Phase IIa human clinical trial of its seasonal influenza VLP (trivalent) vaccine candidate.

12 Dec 2008

High dose flu vaccine boosts immune response in elderly

Giving people age 65 and older a dose four times larger than the standard flu vaccine boosts the amount of antibodies in their blood to levels considered protective against the flu, more so than the standard flu vaccine does. The findings from a study of nearly 4,000 people were presented Oct. 26 at a national meeting on infectious diseases.

26 Oct 2008

Universal vaccine could protect people and pets from deadly flu pandemics

A single vaccine could be used to protect chickens, cats and humans against deadly flu pandemics, according to an article published in the November issue of the Journal of General Virology. The vaccine protects birds and mammals against different flu strains and can even be given to birds while they are still in their eggs, allowing the mass vaccination of wild birds.

20 Oct 2008

Bird flu pandemic would require multi-drug approach

Scientists have uncovered a change in the H5N1 bird flu virus which makes it resistant to the anti-viral drug Tamiflu. The mutation in the N1 component was found in human cases of the disease and suggests that a single drug approach is likely to be ineffective in case of a bird flu pandemic in humans. The findings by a team at the Medical Research Council's National Institute for Medical Research are published in Nature.

15 May 2008

WHO warns Aussies to prepare for deadly flu

The World Health Organisation (WHO) is warning Australians to prepare for a potentially deadly flu season.

23 Mar 2008

Research helps explain why some flu strains cause major pandemics and others lead to seasonal epidemics

The exchange of genetic material between two closely related strains of the influenza A virus may have caused the 1947 and 1951 human flu epidemics, according to biologists.

6 Mar 2008

Evolutionary analysis of influenza viruses

Reassortment of the influenza A virus occurs frequently throughout its evolutionary history, according to a new study published February 29 in the open-access journal PLoS Pathogens.

1 Mar 2008

Oseltamivir resistance in European Influenza viruses

Preliminary surveillance into antiviral drug susceptibility against seasonal flu viruses currently circulating in Europe has revealed that some of the A (H1N1) viruses (13%) have shown resistance to the antiviral drug, oseltamivir.

29 Jan 2008

Seasonal flu levels trigger use of antiviral drugs

The Health Protection Agency has confirmed that the rate at which influenza viruses are now circulating in England has reached the point which triggers the use of antiviral drugs.

11 Jan 2008

Nanoviricide drug candidate effectiveness confirmed against rabies and influenzas

NanoViricides, Inc. has said that in a confirmatory study, their nanoviricide drug candidates exhibited a consistent 20% to 30% survival in the test animals.

13 Nov 2007

Key differences discovered between avian and human flu

St. Jude scientists have found key features that distinguish influenza viruses found in birds from those that infect humans.

5 Sep 2007

Sanofi pasteur ships doses of Fluzone influenza vaccine for the 2007-2008 season

Sanofi pasteur, the vaccines division of the sanofi-aventis Group, has begun shipment of influenza vaccine (Fluzone, Influenza Virus Vaccine) in the United States for the 2007-2008 season.

13 Aug 2007

Tamiflu could halve the pandemic influenza death toll versus no intervention

Treatment with the oral antiviral Tamiflu (oseltamivir) and prophylaxis for people exposed to infected patients could be one of the most cost-effective strategies for reducing illness and death during an influenza pandemic.

23 Jun 2007