Viral hemorrhagic fevers (VHFs) refer to a group of illnesses that are caused by several distinct families of viruses. In general, the term "viral hemorrhagic fever" is used to describe a severe multisystem syndrome (multisystem in that multiple organ systems in the body are affected). Characteristically, the overall vascular system is damaged, and the body's ability to regulate itself is impaired. These symptoms are often accompanied by hemorrhage (bleeding); however, the bleeding is itself rarely life-threatening. While some types of hemorrhagic fever viruses can cause relatively mild illnesses, many of these viruses cause severe, life-threatening disease.
An experimental vaccine developed in Europe to prevent infection by Crimean-Congo hemorrhagic fever virus (CCHFV) has protected cynomolgus macaques in a new collaborative study from National Institutes of Health scientists.
Texas Biomedical Research Institute in San Antonio, Texas, was awarded $1 million from the Bill & Melinda Gates Foundation to test the efficacy of human monoclonal antibodies (MAbs) for the treatment of SARS-CoV-2 infection.
A group of researchers from Charité - Universitätsmedizin Berlin have confirmed Germany's first-ever case of animal-to-human transmission involving a specific species of virus known as the 'Seoul virus'.
A new study describes two promising small molecules that inhibit a host cell factor, called nucleotide binding oligomerization domain-containing protein 2 (NOD2), that inhibits the replication and spread of many arboviruses. This could lead to the development of broad-spectrum antivirals. The study's findings have been published on the preprint server bioRxiv*.
More than 100 companies have rushed into vaccine development against COVID-19 as the U.S. government pushes for a vaccine rollout at "warp speed" -- possibly by the end of the year -- but the bar set for an effective, long-lasting vaccine is far too low and may prove dangerous, according to Marc Hellerstein of the University of California, Berkeley.
Scientists at Texas Biomedical Research Institute's Southwest National Primate Research Center recently published findings indicating the baboon could prove to be a relevant model to test therapeutics and interventions for neurodegenerative diseases, such as early stage Alzheimer's and related dementias.
Martha Phillips knows exactly how it feels to suddenly find oneself up close to — and unprotected from — a deadly virus.
Scientists at Texas Biomedical Research Institute (Texas Biomed) today announced the launch of a comprehensive research initiative to investigate multiple animal species and their response to the novel coronavirus disease (COVID-19).
Back in February 2018, the World Health Organization (WHO) talked about a new virus that will emerge and wreak havoc across the globe. Disease X was the term used for this new unknown pathogen that might cause a future epidemic.
Robert Stahelin studies some of the world's deadliest viruses. Filoviruses, including Ebola virus and Marburg virus, cause viral hemorrhagic fever with high fatality rates.
The Marburg virus is a close relative of the Ebola virus explain researchers. It may also lead to the deadly life threatening hemorrhagic disease in patients as seen with Ebola. Until now there have been no reported cases of Marburg infection in Sierra Leone say health officials. The detection in the bats however could signal the risk the local population might be at or getting infected.
Scientists have detected Marburg virus in fruit bats in Sierra Leone, marking the first time the deadly virus has been found in West Africa. Eleven Egyptian rousette fruit bats tested positive for active Marburg virus infection. Research teams caught the bats separately in three health districts.
No one knows what makes a mild dengue viral infection morph into a severe and sometimes deadly dengue hemorrhagic fever/dengue shock syndrome.
A new technique that sterilizes male mosquito through radiation shows promise in fighting mosquito-borne illnesses, including Zika, dengue and chikungunya. Soon, health experts plan to test the technique as part of global health efforts to control these diseases.
Scientists funded by the National Institutes of Health have developed an investigational vaccine that protected cynomolgus macaques against four types of hemorrhagic fever viruses endemic to overlapping regions in Africa.
There is currently no vaccine for the Lassa arenavirus, which causes Lassa fever. This hemorrhagic fever, endemic in West Africa, infects up to 300,000 people each year.
The Ebola virus disease (EVD) is a deadly infection that is highly contagious. It has taken thousands of lives across history, with a number of outbreaks mostly happening in West Africa. In the worse outbreak, between 2014 and 2016, there had been 28,616 cases of EVD, 11,310 of whom had died in the continent. Overseas, there had been 36 cases and 15 deaths.
This particular inquiry pertains to CCR5 - a gene which has lately been on the focuses of research worldwide. In particular, CCR5 deletion was used in China to perform the first ever genetic editing on human embryos. It's also known that a CCR5-Δ32 mutation can make people immune to HIV.
In mid-August 2019, human clinical trials were halted in the current Ebola epidemic that has claimed more than 2,100 lives in Africa.
A second experimental Ebola vaccine made by Johnson & Johnson will soon undergo clinical trials in the Ebola affected Democratic Republic of the Congo (DRC) announced health officials. The second round of vaccinations is to begin middle of October this year.