Hepatocellular Carcinoma News and Research

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Hepatocellular Carcinoma is a type of adenocarcinoma, the most common type of liver tumor.

Environmental factors significantly impact gene expression through epigenetic modifications

Epigenetics, the study of changes in gene function that do not involve alterations to the DNA sequence, plays a pivotal role in understanding the complex interplay between genetics and the environment. The review article "Epigenetics and Environmental Health" provides an in-depth analysis of how epigenetic modifications can influence the onset and progression of various diseases, particularly cancer and cardiovascular diseases.

8 Oct 2024

Study links obesity and diabetes to higher recurrence rates in liver cancer

Hepatocellular carcinoma, a type of liver cancer associated with hepatitis infections, is known to have a high recurrence rate after cancer removal.

3 Oct 2024

A promising new therapeutic target for MASLD identified

Using a novel stem cell platform, a team of the Medical University of South Carolina researchers has identified a pathway that could be targeted by drugs to reduce fat accumulation in patients with a common form of fatty liver disease known as metabolic dysfunction-associated steatotic liver disease, or MASLD.

11 Sep 2024

Long-term air pollution exposure and poor lifestyle choices increase risk of non-alcoholic fatty liver disease

Long-term exposure to air pollution and poor lifestyle choices are key contributors to non-alcoholic fatty liver disease (NAFLD), affecting global liver health.

3 Sep 2024

Study reveals key role of A20 protein in controlling inflammation in liver disease

Many individuals worldwide suffer from chronic liver disease (CLD), which poses significant concerns for its tendency to lead to hepatocellular carcinoma or liver failure. CLD is characterized by inflammation and fibrosis.

29 Aug 2024

Breakthrough treatment reduces liver fibrosis in Hepatitis C patients

HCV infection is the underlying cause for chronic Hepatitis C (CHC), liver cirrhosis, and liver cancer or hepatocellular carcinoma (HCC). In 2019, over 2,90,000 people died of HCV-related diseases. Recent medical advancement made a new breakthrough treatment available for patients with hepatitis C. DAAs that block replication of HCV has dramatically transformed the treatment approach with around 90% effective anti-viral response rates. However, it is unclear whether DAAs impact the severity of disease burden caused by liver fibrosis.

21 Aug 2024

Neoadjuvant immunotherapy yields comparable outcomes in high-risk liver cancer surgery

Patients with liver cancer who received immune checkpoint inhibitors (ICIs) before surgery-;including those who would not have been eligible for surgery by conventional criteria-;had similar outcomes to patients who received surgery upfront, according to results from a retrospective study.

15 Aug 2024

The real cost of processed foods: How Western diets are harming global health

A recent study in Nature Medicine reviews the adverse effects of Western diets on human health, highlighting increased risks of chronic diseases and gut dysbiosis. Researchers call for global awareness and promotion of healthier dietary patterns.

6 Aug 2024

Fecal microbiota transplants can boost the effectiveness of immunotherapy in gastrointestinal cancers

Findings from a small, proof-of-concept clinical trial have suggested that fecal microbiota transplants (FMTs) can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers.

25 Jul 2024

Navigating adjuvant therapy options in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and is the third leading cause of cancer-related deaths.

16 Jul 2024

Ultrasound techniques for the surveillance, diagnosis, and treatment of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and one of the leading causes of cancer-related deaths worldwide. Early detection and accurate diagnosis are crucial for effective management and improved survival rates.

16 Jul 2024

Transforming growth factor beta inhibition boosts NK cell therapy against hepatocellular carcinoma

Researchers at University of California San Diego have found that the most common form of liver cancer -; one with a high mortality rate -; can be better targeted and treated using an innovative new stem cell-derived therapy, according to a recently published study in Cell Stem Cell.

9 Jul 2024

GLP-1 drugs found to lower cancer risk in diabetes patients

Research finds that GLP-1 receptor agonists significantly reduce the risk of 10 out of 13 obesity-associated cancers in type 2 diabetes patients compared to insulins, but show varied results against metformin.

8 Jul 2024

Advancements in immunotherapy for hepatocellular carcinoma offer hope to patients

Hepatocellular carcinoma (HCC) is a primary liver cancer predominantly arising from chronic liver diseases such as hepatitis B and C infections, alcohol abuse, and metabolic disorders.

2 Jul 2024

Fibrinogen-like protein 1 plays dual role in liver regeneration and hepatocellular carcinoma recurrence

Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality globally, exhibits a dismal five-year survival rate of only 18%.

2 Jul 2024

Study finds lower cancer risk with alcohol abstinence and rehabilitation

A new study conducted by the Centre for Addiction and Mental Health (CAMH), Bordeaux University Hospital, France, and the World Health Organization (WHO) has found that individuals with alcohol dependence who undergo rehabilitation or maintain abstinence experience significantly lower risks of developing alcohol-associated cancers.

26 Jun 2024

Senecavirus A could be a promising new therapeutic approach for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly aggressive tumor with limited treatment options and high mortality.

25 Jun 2024

Multi-regional sampling uncovers hidden complexity in liver cancer

A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

25 Jun 2024

Review highlights the rapidly evolving landscape of hepatocellular carcinoma treatment

Hepatocellular carcinoma (HCC), a prevalent form of cancer, profoundly influences the progression and prognosis of the disease through immune response mechanisms.

22 May 2024

Study uncovers sex-based disparities in liver transplant survival rates

Liver transplantation is a life-saving option for those with hepatocellular carcinoma (HCC), the most prevalent type of liver cancer.

9 May 2024