Hepatology News and Research

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Hepatology is the branch of medicine that incorporates study of liver, gallbladder, biliary tree and pancreas as well as management of their disorders.

Hepatitis C therapy peginterferon alfa-2b shows promise

The hepatitis C therapy peginterferon alfa-2b, when given as low-dose maintenance therapy, can prevent disease progression in certain patients who failed previous interferon-based hepatitis C therapies and have advanced liver disease, according to findings from a large, four-year study presented today at the 43rd annual meeting of the European Association for the Study of the Liver (EASL).

24 Apr 2008

Combining liver cancer treatments doubles survival rates

By combining the use of stents and photodynamic therapy, also called SpyGlass, physicians at the University of Virginia have been able to significantly increase survival rates for patients suffering from advanced cholangiocarcinoma, cancer of the liver bile duct.

16 Apr 2008

Protein sulfatase 2 a possible treatment target for liver cancer recurrence and survival

Deadly and difficult to treat, liver cancer has long resisted attempts by researchers to develop ways to prolong life and prevent recurrence.

11 Apr 2008

Patient interventions with low-income and minorities increases colonoscopy rates

Patient interventions are necessary to achieve higher rates of colorectal cancer screening in low-income and minority patients, according to two studies in the current issue of Clinical Gastroenterology and Hepatology , the official journal of the American Gastroenterological Association (AGA) Institute.

2 Apr 2008

Nonalcoholic fatty liver disease related to cardiovascular fitness

Patients with nonalcoholic fatty liver disease (NAFLD) have suboptimal levels of cardiovascular fitness, muscle strength, body composition and physical fitness, according to a new study.

25 Mar 2008

Big increase in hepatitis C-related deaths in the United States

Hepatitis C-related deaths in the United States increased by 123 percent from 1995 through 2004, the most recent year for which data are available. Mortality rates peaked in 2002, then declined slightly overall, while continuing to rise among people 55 to 64 years old.

25 Mar 2008

BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients

New BARACLUDE (entecavir) data presented demonstrated a continued low incidence of resistance in nucleoside-naïve patients through five years of treatment. In the nucleoside-naïve chronic hepatitis B patients analyzed, no additional patient developed resistance in the fifth year (n=108).

25 Mar 2008

Combined therapeutic approach of stenting and photodynamic therapy improves survival in late stage liver cancer patients

A combined therapeutic approach of stenting and photodynamic therapy may improve survival rates for patients suffering from advanced liver bile duct cancer, according to a study published this month in Clinical Gastroenterology and Hepatology , the official journal of the American Gastroenterological Association (AGA) Institute.

12 Mar 2008

Serum fibrosis markers correlate with liver fibrosis stage in patients with advanced chronic hep C

A prospective study of patients with advanced chronic hepatitis C (CHC) revealed that a 3-variable model of serum fibrosis markers, including serum HA, TIMP-1 and platelet count, could identify cirrhosis with better accuracy than other published models.

4 Mar 2008

Elevated liver enzymes associated with higher future mortality

A new population-based epidemiological study has found that elevated liver enzymes discovered during routine medical care are associated with higher future mortality.

4 Mar 2008

Capsule endoscopy detects intestinal damage caused by celiac disease

Mayo Clinic researchers have found that capsule endoscopy can provide a magnified view of the intestinal damage caused by celiac disease.

28 Feb 2008

Children's Hospital 1 of 10 pediatric hospitals in US selected to study liver disease in kids

Children's Hospital of Pittsburgh of UPMC has been selected to join an effort among select centers in the United States and Canada to collect and study information necessary to understand the possible causes and treatment of a destructive liver disease called primary sclerosing cholangitis (PSC).

27 Feb 2008

New Jefferson trial to test radiation-emitting beads against advanced liver cancer

Liver cancer specialists at Jefferson's Kimmel Cancer Center in Philadelphia are beginning an 18-month study of a new treatment for liver cancer.

13 Feb 2008

Two new studies examine non-invasive ways to determine liver fibrosis and cirrhosis

An enhanced version of the Original European Liver Fibrosis panel was found to have good diagnostic accuracy for fibrosis in patients with non-alcoholic fatty liver disease. Conversely, transient elastography was unreliable for detecting cirrhosis in patients with acute liver damage. The studies are published in the February issue of Hepatology, a journal by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The articles are also available online at Wiley Interscience.

5 Feb 2008

Ascal (calcium carbasalate) not safer than aspirin

Changing prescription of low-dose aspirin into calcium carbasalate (brand name: Ascal) to prevent peptic ulcerations is not useful. Peptic ulcers are evenly distributed among users of calcium carbasalate and aspirin, for secondary prevention of myocardial infarction.

5 Feb 2008

Nanobac announces Baylor initial results for nanoparticle and gall stone formation study

Nanobac Pharmaceuticals Inc has announced that scientists at the Baylor College of Medicine, working under a collaborative agreement with Nanobac, have cited evidence showing the presence of calcifying nanoparticles (CNPs) in surgically resected gallbladders with cholelithiasis (Gall Stones).

15 Jan 2008

Review of transplant issues in patients with biliary atresia

The most common indication worldwide for pediatric transplantation, biliary atresia is also the most common cause of chronic liver disease in newborns.

9 Jan 2008

New biomarker for predicting liver cancer spread and survival discovered

New research has shown that a unique pattern of microRNAs, small RNA molecules that regulate gene activity, can accurately predict whether liver cancer will spread and whether liver cancer patients will have shorter or longer survival, even patients with early stage disease.

7 Jan 2008

Shorter HCV treatment shows notable success

Two new randomized controlled trials show that treating Hepatitis C (HCV) with peginterferon and ribavirin for shorter durations can yield success rates similar to those from longer treatment lengths, with cost-savings and lower risk of serious side effects.

3 Jan 2008

MRI techniques evolving towards better assessment of liver fibrosis

MRI imagery is emerging as a non-invasive way to determine the existence and extent of hepatic fibrosis.

3 Jan 2008

Hepatology News and Research

Further Reading

Hepatitis C therapy peginterferon alfa-2b shows promise

Combining liver cancer treatments doubles survival rates

Protein sulfatase 2 a possible treatment target for liver cancer recurrence and survival

Patient interventions with low-income and minorities increases colonoscopy rates

Nonalcoholic fatty liver disease related to cardiovascular fitness

Big increase in hepatitis C-related deaths in the United States

BARACLUDE data show low resistance over 5 years in nucleoside-naive hepatitis B patients

Combined therapeutic approach of stenting and photodynamic therapy improves survival in late stage liver cancer patients

Serum fibrosis markers correlate with liver fibrosis stage in patients with advanced chronic hep C

Elevated liver enzymes associated with higher future mortality

Capsule endoscopy detects intestinal damage caused by celiac disease

Children's Hospital 1 of 10 pediatric hospitals in US selected to study liver disease in kids

New Jefferson trial to test radiation-emitting beads against advanced liver cancer

Two new studies examine non-invasive ways to determine liver fibrosis and cirrhosis

Ascal (calcium carbasalate) not safer than aspirin

Nanobac announces Baylor initial results for nanoparticle and gall stone formation study

Review of transplant issues in patients with biliary atresia

New biomarker for predicting liver cancer spread and survival discovered

Shorter HCV treatment shows notable success

MRI techniques evolving towards better assessment of liver fibrosis

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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