High throughput screening News and Research

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High-throughput screening (HTS) allows scientists to test thousands of samples at once. These samples can be of a wide variety, and include, but are not limited to, amino acids, chemical compounds or cells.

Brookhaven target new anti-SARS virus drugs

Scientists at Brookhaven National Laboratory have set the stage for the rapid identification of compounds to fight against severe acquired respiratory syndrome (SARS), the atypical pneumonia responsible for about 800 deaths worldwide since first recognized in late 2002.

14 Nov 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006

Molecular switch that regulates fat and cholesterol production identified

Researchers at Harvard Medical School and Massachusetts General Hospital have identified how a molecular switch regulates fat and cholesterol production

2 Aug 2006

New technique to speed discovery of drug targets in chemical genetics

Researchers at Fox Chase Cancer Center have developed a new technique to speed discovery of drug targets in chemical genetics. Fox Chase researcher Jeffrey R. Peterson, Ph.D., and his colleagues describe a new way to swiftly find the proteins targeted by small molecule inhibitors during high-throughput screening (HTS) experiments. The new work offers a critical solution to a common stumbling block in this booming field of drug discovery.

26 Apr 2006

Menthol discovery could point towards new pain therapies

This new understanding could lead to potential advances in pain therapy, the researchers said. Moreover, the scientists envision that their method may be potentially useful in studying the activation mechanism of other drugs and proteins.

13 Mar 2006

New DNA-based cell adhesion strategy

A new technique in which single strands of synthetic DNA are used to firmly fasten biological cells to non-biological surfaces has been developed by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley.

9 Feb 2006

Screening test for cells that activate immune system

UT Southwestern Medical Center researchers are the first to create a large-scale, cell-based screening method that identifies which compounds activate immune-response cells that hold promise for future cancer-fighting vaccines.

12 Sep 2005

Researchers develop screening test for cells that activate immune system

7 Sep 2005

Maxim Pharmaceuticals issued patent for method of identifying therapeutically effective immunosupressive agents

Maxim Pharmaceuticals have announced the United States Patent and Trademark Office issued U.S. patent number 6,828,091 B2, entitled "Method of Identifying Immunosuppressive Agents."

23 Apr 2005

Researchers set a new standard in the design and engineering of nuclear hormone receptor-based genetic on-off switches

Researchers at the University of Illinois at Urbana-Champaign have set a new standard in the design and engineering of nuclear hormone receptor-based genetic on-off switches, without causing new problems or aggravating existing ones.

7 Apr 2005

New ion channel drug targets to emerge in pharmaceutical discovery

The identification and structural determination of channel proteins, and their validation as therapeutic targets using high throughput cell based and multiplexed screening technologies, have furnished an increase role for ion channel targets in the drug discovery and development pipelines in the pharmaceutical and biotechnology industries.

4 Apr 2005

Nano-enabled drug discovery solutions will generate revenues of $1.3 billion in 2009

According to a new report by NanoMarkets, an industry consultancy based here, nano-enabled drug discovery solutions will generate revenues of $1.3 billion in 2009 and grow to $2.5 billion in 2012.

8 Mar 2005

Home HIV-AIDS test could be a reality within two years

A portable device similar to a home pregnancy test that can quickly detect the presence of infectious diseases, including HIV-AIDS and measles as well as biological agents such as Ricin and anthrax, is the goal of a new joint research project

17 Jan 2005

Molecular Devices introduces fatty acid uptake assay to target metabolic diseases

Molecular Devices Corporation announced the launch of its QBT Fatty Acid Uptake Assay Kit, the first assay kit that addresses the need for a single-step, homogenous in vitro assay for fatty acid uptake for use in high- throughput screening and metabolic disease research.

12 Jan 2005

New portable infectious disease detector

A portable device similar to today's home pregnancy tests that can quickly detect the presence of infectious diseases, including HIV-AIDS and measles, as well as biological agents such as ricin and anthrax, is the object of a new joint university/industry research project.

10 Jan 2005

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays

Pharmaceutical, biotechnology and drug discovery companies are increasingly turning their attention to cell-based assays, as these assays offer a more accurate representation of the real-life cell model than the traditional enzyme- or antibody-based assays.

13 Dec 2004

As mobile phone use rises, possibility of unseen biological impact is quietly troubling

Cell biologists are of two minds about the possible biological effects of mobile phone radiation. In the mid-1990s, studies describing possible pathological effects on tissues bombarded with low-level radio frequencies (RF) were first featured in the popular press and then discredited by scientists.

4 Dec 2004

Study links a novel protein pathway to the aggressive progression of breast cancer

Cytogen Corporation today announced the publication of a study linking a novel protein pathway to the aggressive progression of breast cancer.

24 Nov 2004

Microfluidics help lab-on-a-chip development skyrocket

Lab-on-a-chip (LOC) development has skyrocketed in the last couple of years due to constant efforts in harnessing microfluidics and µTAS to improve the LOC design and function. The distinct advantages that they bestow on applications are pushing the commercial potential of LOCs.

28 Sep 2004

Outsourcing the way to control spiraling R&D budgets in drug industry

Companies developing new drugs for the global market must deal with the rising costs of the R&D process – and outsourcing may well be the best route. That's the verdict of Dr Faiz Kermani, a specialist in outsourcing and research development for the pharmaceutical industry.

14 Jun 2004