Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Depressed older adults more likely to develop mild cognitive impairment

Older adults with depressive symptoms are more likely than those without depression to develop mild cognitive impairment (MCI) within six years, according to a study conducted by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

9 Mar 2006

Discovery of compound that reduces hallmark lesions of Alzheimer's disease in mice

Researchers at UC Irvine have found that a new compound not only relieves the cognitive symptoms of Alzheimer's disease, but also reduces the two types of brain lesions that are hallmarks of this devastating disease, thereby blocking its progression.

7 Mar 2006

Cell-death mechanism linked to developmental and degenerative brain disorders

Conclusive evidence that neurodevelopmental disorders such as mental retardation and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and ataxias can be caused, at least in part, by specific gene defects that interfere with the electrical impulses of rapid-firing brain nerve cells called bursting neurons.

1 Mar 2006

Spinocerebellar ataxia and other neurodegenerative diseases might be treatable with drugs that alter the activity of potassium channels

For the first time, researchers have linked mutations in a gene that regulates how potassium enters cells to a neurodegenerative disease and to another disorder that causes mental retardation and coordination problems.

27 Feb 2006

We may learn best on an empty stomach!

Researchers at Yale School of Medicine have found evidence that a hormone produced in the stomach directly stimulates the higher brain functions of spatial learning and memory development.

23 Feb 2006

Discovery of molecule that may hold key to learning and memory

Independent research teams from Harvard Medical School and Children's Hospital Boston have identified a master protein that sheds light on one of neurobiology's biggest mysteries--how neurons change as a result of individual experiences.

23 Feb 2006

Vitamin B3 variant reverses effects of fetal alcohol syndrome in mice

A form of vitamin B3 called nicotinamide can reverse the molecular, cellular, and behavioral effects of fetal alcohol syndrome (FAS) in mice, according to a study by physician-scientists at Weill Medical College of Cornell University.

21 Feb 2006

Brain scans may detect neurological decline in normal people

Brain scans may detect neurological changes in people who exhibit no outward signs of cognitive decline but who later develop dementia or mental impairment, according to the results of a new study led by researchers at the University of California, Berkeley.

16 Feb 2006

Single memory is processed in three separate parts of the brain - important for search to understand memory disorders

UCI researchers have found that a single brief memory is actually processed differently in separate areas of the brain - an idea that until now scientists have only suspected to be true.

12 Feb 2006

Depression linked to Alzheimer's

A lifetime history of depression is associated with increased plaques and tangles in the brains of those with Alzheimer's disease and more rapid cognitive decline, according to a study by researchers at the Alzheimer's Disease Research Center at Mount Sinai School of Medicine.

9 Feb 2006

Treatment of down syndrome in mice restores nerve growth in cerebellum

Researchers at Johns Hopkins restored the normal growth of specific nerve cells in the cerebellum of mouse models of Down syndrome (DS) that were stunted by this genetic condition. The cerebellum is the rear, lower part of the brain that controls signals from the muscles to coordinate balance and motor learning.

25 Jan 2006

Working your brain hard reduces risk of dementia

Research from the University of New South Wales (UNSW), Australia, provides the most convincing evidence to date that complex mental activity across people's lives significantly reduces the risk of dementia. The researchers found that such activity almost halves the incidence of dementia.

25 Jan 2006

Breakthrough in lupus research

A major breakthrough in lupus research - one that may fundamentally change thinking on how the disease affects behavior and cognition - was reported in the January 17, 2006 Proceedings of the National Academy of Sciences (PNAS).

25 Jan 2006

Novel compound stops brain cell degeneration in Alzheimer's disease

Drug discovery researchers at Northwestern University have developed a novel orally administered compound specifically targeted to suppress brain cell inflammation and neuron loss associated with Alzheimer's disease.

22 Jan 2006

Alzheimer's may be triggered by neuron division

A new study in mice suggests that Alzheimer's disease (AD) may be triggered when adult neurons try to divide. The finding helps researchers understand what goes wrong in the disease and may lead to new ways of treating it.

18 Jan 2006

Single gene may hold key to schizophrenia

By deleting a single gene in a small portion of the brains of mice, researchers at UT Southwestern Medical Center found that the animals were affected in a way resembling schizophrenia in humans.

18 Jan 2006

The sweet answer to a poor memory

Sweet tooth types out there will be delighted to learn that those sweet and sugary drinks may improve the memory.

16 Jan 2006

Study establishes two forms of mild cognitive impairment

Mild cognitive impairment (MCI), a transitional stage between normal cognition and Alzheimer's disease, exists in two different forms, according to a study published today by researchers from the University of Pittsburgh School of Medicine and the University of California, Los Angeles in the Archives of Neurology.

9 Jan 2006

Brain volume may be used as an early detection system for dementia

Reduced volume, or atrophy, in parts of the brain known as the amygdala and hippocampus may predict which cognitively healthy elderly people will develop dementia over a six-year period, according to a study in the January issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

2 Jan 2006

Long-term stress can impair short-term memory

Researchers believe that this occurs because constant stress affects an area of the brain necessary for learning and memory, and the underlying mechanisms for this may also be to blame in more serious ailments, such as post-traumatic stress disorder (PTSD) and severe depression.

15 Dec 2005