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Partial nephrectomy efficacious for clinical T2 renal masses

Survival outcomes and overall complication rates of partial nephrectomy for clinical T2 renal masses are comparable to those of radical nephrectomy when the pathological staging, histology and grading of the tumours are similar, researchers report.

30 Oct 2014

Afatinib active against NSCLC nervous system metastases

Heavily pretreated patients with epidermal growth factor receptor-mutated non-small-cell lung cancer and central nervous system metastases may benefit from treatment with afatinib, say German researchers.

22 Oct 2014

Six platinum cycles no better than four for advanced NSCLC

Six cycles of adjuvant platinum-based chemotherapy is no better than three or four cycles for patients with advanced non-small-cell lung cancer, meta-analysis results suggests.

22 Oct 2014

New research suggests that exposure to aluminium may reduce male fertility

And the team of scientists, at the universities of Lyon and Saint-Etienne in France and Keele in the UK, found that the higher the aluminium, the lower sperm count.

21 Oct 2014

UCSD researchers define epidemiology of gastrointestinal stromal tumors

Researchers at the University of California, San Diego School of Medicine have, for the first time, clearly defined the epidemiology of gastrointestinal stromal tumors (GIST), which occur primarily in the lining of the stomach and small intestine.

8 Oct 2014

Abbvie announces multiple study results of veliparib investigational compound in NSCLC patients

AbbVie released interim results from an ongoing Phase 2 study of its investigational compound veliparib in combination with chemotherapy, which showed a 35 percent improvement (P-value=0.14) in progression-free survival (PFS) and a 30 percent improvement (P-value=0.21) in overall survival (OS) in patients with previously untreated metastatic or advanced non-small cell lung cancer (NSCLC).

30 Sep 2014

Understanding ways to treat, cure eosinophilic gastritis

Investigators at Cincinnati Children's Hospital Medical Center have published the first study to extensively characterize eosinophilic gastritis (EG).

24 Sep 2014

Current smokers at increased risk of developing SPLC

Non-small cell lung cancer (NSCLC) survivors who never smoked or who are former smokers at the time of diagnosis have a lower risk of developing secondary primary lung cancers (SPLC) compared to those who are current smokers, suggesting that increased tobacco exposure is associated with a higher risk of SPLC, according to research presented today at the American Society for Radiation Oncology's 56th Annual Meeting.

17 Sep 2014

Mutant allele frequency predicts lung cancer TKI response

Tyrosine kinase inhibitor sensitivity may be predicted by the frequency of a point mutation in the epidermal growth factor receptor gene, suggests a study of Japanese patients with advanced lung adenocarcinoma.

28 Aug 2014

High PD-L1 expression linked to reduced survival in NSCLC

Overexpression of programmed death-ligand 1 is independently associated with the presence of epidermal growth factor receptor gene mutations and poor prognosis in patients with non-small-cell lung cancer, Japanese researchers report.

28 Aug 2014

CD157 important in malignant pleural mesothelioma

CD157 plays a pivotal role in the progression of malignant pleural mesothelioma and may be useful in the stratification of patients into different prognostic groups, Italian research suggests.

20 Aug 2014

MGH-developed microfluidic device may help study key steps involved in development of tumor metastasis

A microfluidic device developed at Massachusetts General Hospital may help study key steps in the process by which cancer cells break off from a primary tumor to invade other tissues and form metastases.

19 Aug 2014

TAZ represents a novel therapeutic target in NSCLC

Patients with non-small-cell lung cancer who express high levels of transcriptional coactivator with PDZ-binding motif may be a clinically distinct subgroup with an unfavourable prognosis, researchers report.

16 Jul 2014

New findings paint optimistic picture of women's chances of surviving breast cancer

New findings from Fox Chase Cancer Center paint a relatively optimistic picture of women's chances of surviving a subset of breast cancers that have spread to the chest wall or skin, but not beyond.

10 Jul 2014

Partial nephrectomy predicts survival among metastatic RCC patients

Cytoreductive nephrectomy predicts improved survival among patients with metastatic renal cell carcinoma and synchronous metastases who have received first-line treatment with sunitinib, indicate study findings.

1 Jul 2014

Use of NMR in diagnostic research: an interview with Elaine Holmes, Imperial College

The Phenome Center developed out of the Olympic drug testing facility, and we've adapted it so that we use NMR spectrometry, which we have three spectrometers, and mass spectrometry, to take blood and urine from hundreds and thousands of people and profile them to get a biochemical fingerprint of every person.

From Bruker BioSpin - NMR, EPR and Imaging 1 Jul 2014

Prostate biopsy method impacts cancer risk profile

Prostate cancers that are classified as “low risk” based on conventional prostate biopsy and histology are frequently found to be higher risk when assessed using the newer targeted biopsy method, US researchers have warned.

5 Jun 2014

Researchers analysis adjuvant chemotherapy's impact on overall survival in patients with stage III STS

Fox Chase Cancer Center researchers have carried out the first retrospective analysis of adjuvant chemotherapy's impact on overall survival in patients with stage III soft tissue sarcomas (STS), adjusted for socioeconomic status and other variables.

31 May 2014

MedPage and CollabRx introduce CancerRx to help oncologists, pathologists

MedPage Today, a property of Everyday Health, Inc. and CollabRx, Inc. announced today the introduction of a new physician resource, CancerRx,™ an IOS application designed to help oncologists and pathologists navigate the complex landscape of oncology therapeutic options.

28 May 2014

Cryogenically-cooled technology significantly enhances current capabilities of cardiac and brain MRI in mice

To effectively study cardiac morphology and function, or follow neuroinflammatory processes in the brain, image quality is everything. The current capabilities of cardiac and brain MRI in mice are being significantly enhanced by cryogenically-cooled technology, which is proving invaluable to researchers around the world.

From Bruker BioSpin - NMR, EPR and Imaging 14 May 2014