Histology News and Research

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Novel method provides faster and more precise diagnostics in histopathology

Histology is the study of biological tissues at a microscopic level. Also called microscopic anatomy, histology is widely used to provide diagnosis of cancer and other diseases.

30 Apr 2021

Experimental evidence that ADAM17 inhibition prevents severe COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that is contagious in humans. It is the causal agent of the ongoing coronavirus 2019 (COVID-19) pandemic. This virus causes a mild to severe infection and has claimed over 2.95 million lives worldwide. SARS-CoV-2 is the successor to SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak.

13 Apr 2021

Researchers reveal a mechanistic link in kidney cancer between fat metabolism and obesity

Altered cellular energetics, a hallmark of cancers, has been associated with obesity. However, links between systemic energy regulation and aberrant cancer cell metabolism have been lacking.

25 Mar 2021

Novel protein construct prevents lethal COVID-19 in mice

Researchers in the United States have developed a novel protein that prevented lethal disease among mice infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

16 Mar 2021

Nivolumab monotherapy is effective treatment option for relapsed malignant mesothelioma

Nivolumab monotherapy is an effective treatment option for relapsed malignant mesothelioma (MM), according to research presented today at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.

31 Jan 2021

LCMC3 trial: Neoadjuvant atezolizumab prior to lung cancer surgery meets primary endpoint

(Primary analysis of the Lung Cancer Mutation Consortium (LCMC) 3 study revealed that neoadjuvant atezolizumab prior to lung cancer surgery was well tolerated by patients and met its primary endpoint of 20% major pathologic response rate, according to research presented today at the International Association for the Study of Lung Cancer's World Conference on Lung Cancer.

31 Jan 2021

New method could provide additional insight into brain tumors

A look at RNA tells us what our genes are telling our cells to do, and scientists say looking directly at the RNA of brain tumor cells appears to provide objective, efficient evidence to better classify a tumor and the most effective treatments.

19 Jan 2021

Gene-regulating snippet of RNA may contribute to breast cancer metastasis

Cold Spring Harbor Laboratory (CSHL) scientists have discovered a gene-regulating snippet of RNA that may contribute to the spread of many breast cancers.

22 Dec 2020

Researchers study the mechanisms of skin aging

The ageing process is most apparent on the skin. In the newly opened "SKINMAGINE" (Multimodal Imaging of Aging and Senescence of the Skin) Christian Doppler Laboratory, dermatologists from MedUni Vienna have joined forces with biotechnologists from the University of Natural Resources and Applied Life Sciences Vienna and chemists from Vienna University of Technology, as well as the company Chanel, to study the interaction of metabolism, cellular communication and cellular quality control in skin ageing accelerated by environmental stress.

16 Dec 2020

A new potential COVID-19 vaccine candidate: YF-S0

A recent study published in the journal Nature describes the safety and efficacy of a live-attenuated yellow fever 17D (YF17D) vector-based vaccine candidate expressing a non-cleavable form of the spike protein of severe acute respiratory coronavirus 2 (SARS-CoV2).

2 Dec 2020

Mild electrical stimulation with heat shock exerts protective effect against nephrotic syndrome

A research team from Kumamoto University in Japan has found that the combination of weak pulsed electrical current and heat exerts anti-inflammatory and anti-fibrotic effects in the kidneys, as well as a protective effect against nephrotic syndrome (NS) by inhibiting apoptosis (cell death) of kidney cells.

30 Nov 2020

Could beta-blockers be a potential treatment for COVID-19?

News-Medical spoke to researchers about their latest research into beta-blockers, and how they could potentially be used to treat COVID-19.

27 Nov 2020

Computational method could predict immunotherapy response in patients with advanced melanoma

A computational method that combines clinicodemographic variables with deep learning of pre-treatment histology images could predict response to immune checkpoint blockade among patients with advanced melanoma.

18 Nov 2020

Targeting BCAP with new drugs could benefit people with inflammatory bowel disease

Managing the activity of the BCAP protein could help the body repair intestinal tissue from damage caused by inflammation, according to a new study led by experts at Cincinnati Children's.

17 Nov 2020

Goblet cells are prime target for SARS-CoV-2, study finds

A recent study reports that in the airway of patients with chronic obstructive pulmonary disease (COPD), a type of airway epithelial cell – called a goblet cell – presents a prime target for the virus and plays a vital role in promoting viral replication in this tissue.

16 Nov 2020

Patients' own stem cells can be used to grow new bones, study shows

A new, groundbreaking study from the University of Bergen shows that a patients' own stem cells can be used to grow new bone.

16 Nov 2020

Study: More women with invasive breast cancer could potentially be spared an axillary surgery

More women could potentially be spared an axillary lymph node dissection -- the surgical removal of 10-20 lymph nodes -- a procedure that causes disabling arm swelling in up to 25% of women, according to a UCLA study led by Dr. Maggie DiNome, chief of breast surgery at the David Geffen School of Medicine at UCLA.

22 Oct 2020

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Neoadjuvant, or pre-surgical, combination treatment with the immune checkpoint inhibitors tremelimumab (anti-CTLA-4) and durvalumab (anti-PD-1) was well-tolerated and showed early signs of activity in certain patients with localized bladder cancer who do not have standard treatment options available, according to a Phase I clinical trial conducted by The University of Texas MD Anderson Cancer Center.

13 Oct 2020

Even mild fatty liver disease associated with higher risk of all-cause mortality

Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis.

12 Oct 2020

Skoltech researchers identify new panel of potential biomarkers for liver cancer diagnosis

A group of Skoltech scientists led by a Skoltech and MSU professor Olga Dontsova discovered a novel liver-specific non-coding RNA.

30 Sep 2020