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Scientists reveal major players in severe muscle damage caused by sepsis

Scientists from the Institut Pasteur, Paris Descartes University, Sainte-Anne Hospital and the CNRS have recently published a paper in Nature Communications in which they reveal major players in the severe muscle damage caused by sepsis, or septicemia, which explains why many patients suffer debilitating muscle impairment long-term after recovery.

17 Dec 2015

Kolltan announces presentation of data from KTN0158 preclinical study in mast cell tumors at ESMO 2015

Kolltan Pharmaceuticals, Inc. today announced the presentation of data from a preclinical study evaluating KTN0158 in dogs with spontaneous mast cell tumors. KTN0158 is a proprietary, humanized anti-KIT IgG1 monoclonal antibody drug candidate being developed as a potential therapy for cancer and mast cell-related diseases.

28 Sep 2015

New article published in Spanish Journal of Pathology highlights a rare case of Hodgkin's lymphoma

Dr. Jerónimo Forteza, Professor of Pathology and Director of the Valencian Institute of Pathology, Catholic University of Valencia "San Vicente Mártir," recently published an article in the Spanish Journal of Pathology on the case of a patient with Hodgkin's lymphoma. Medicine student Pablo Sánchez Vela performed this diagnostic work under the supervision of Dr. Forteza.

3 Jun 2015

Alnylam files clinical trial application for alpha-1 liver disease, presents data at DDW

Alnylam Pharmaceuticals, Inc. has announced that it has filed a Clinical Trial Application (CTA) with the U.K. Medicines and Healthcare products Regulatory Agency (MHRA) to initiate a Phase 1/2 clinical trial with ALN-AAT, a subcutaneously administered investigational RNAi therapeutic targeting alpha-1 antitrypsin (AAT) for the treatment of AAT deficiency-associated liver disease (alpha-1 liver disease).

19 May 2015

Researchers report new label-free chemical imaging that provides similar information as molecular stains

Histopathology is a cornerstone of modern biomedical research. Yet, the practice of histopathology has evolved just a few times -- non-specific stains in the late 19th century, immunohistochemical staining in the mid-to-late 20th century and digital imaging/computerized analysis at the turn of the 20th century. In all cases, prepared biopsy samples are stained and examined under a light microscope.

15 May 2015

CNIO researchers identify new strategy to combat cancer

Scientists from the Spanish National Cancer Research Centre have discovered a new strategy to fight cancer, which is very different from those described to date. Their work shows for the first time that telomeres -- the structures protecting the ends of the chromosomes -- may represent an effective anti-cancer target: by blocking the TRF1 gene, which is essential for the telomeres, they have shown dramatic improvements in mice with lung cancer.

14 May 2015

Researchers devise novel method to perform NIR optical measurements of resected breast tissue

Roughly 1 in 4 women having breast conserving surgery (BCS) return to the surgical suite for further resection because of cancerous tissue left behind due to unclear margins. Investigators at the Optics in Medicine Lab at Dartmouth's Thayer School of Engineering and Norris Cotton Cancer Center, led by Brian W. Pogue, PhD and Keith Paulsen PhD, with first author and PhD candidate David M. McClatchy III, devised a novel approach to perform near infrared (NIR) optical measurements of resected breast tissue after the margins have had their traditional marking by the surgeon to preserve information about their orientation for potential follow-up surgeries.

14 May 2015

ATA guidelines provide recommendations for managing thyroid nodules and thyroid cancer in children

Previous guidelines from the American Thyroid Association for evaluating and managing thyroid nodules and thyroid cancers targeted adults. Recognizing the potential differences in clinical presentation and long-term outcomes, and the potential risks of overly aggressive therapy in pediatric patients with thyroid cancer, an ATA Task Force developed management guidelines for children with thyroid nodules and differentiated thyroid cancer (DTC), which are published in Thyroid, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers and the official journal of the American Thyroid Association.

23 Apr 2015

New laser technology shows promise for cancer treatment

Surgeons rely on 200-year-old technology when removing cancer--sight and touch--to determine how much to remove and what to leave alone. Laser technology pioneered at Florida Atlantic University has the promise to help a surgeon better determine if an area is cancer or healthy tissue. Moreover, when combined with laser treatment for cancer, this work lays the groundwork for laser robotic treatment of cancer.

16 Feb 2015

CT screening highly sensitive, specific for lung cancer detection

Low-dose computed tomography screening for lung cancer has high specificity and high sensitivity, with just a small number of interval cancers, finds an interim analysis of the NELSON trial.

19 Nov 2014

Combination of NASBA and real-time qPCR detects aspergillosis with 100% accuracy

The fungal infection invasive aspergillosis (IA) can be life threatening, especially in patients whose immune systems are weakened by chemotherapy or immunosuppressive drugs. Despite the critical need for early detection, IA remains difficult to diagnose.

14 Aug 2014

Collaboration classification useful for Japanese lung cancer patients

Epidermal growth factor receptor status and prognosis in Japanese patients can be predicted by a recently developed lung adenocarcinoma classification system, say researchers.

23 Jul 2014

Epigenetic test helps eliminate unnecessary repeat prostate biopsies

More than one million prostate biopsies are performed each year in the U.S. alone, including many repeat biopsies for fear of cancer missed. Therefore there is a need to develop diagnostic tests that will help avoid unnecessary repeat biopsies.

22 Jul 2014

New fiber-optic device helps clinicians diagnose cancer at early-stage

An engineering researcher at the University of Arkansas has developed an inexpensive, endoscopic microscope capable of producing high-resolution, sub-cellular images of tissue in real time.

16 Apr 2014

Genotyping strategy could boost celiac screening efficacy

Genotyping for human leukocyte antigen followed by biopsy is a sensitive strategy for detecting histopathologic lesions in the close relatives of people with celiac disease, research indicates.

24 Dec 2013

Experts develop new working formulation for reporting of cardiac antibody-mediated rejection

Antibody-mediated rejection of the transplanted heart is a recognized clinical complication and a major limitation to survival of patients who have undergone heart transplantation. Experts have now developed a new working formulation for the pathologic diagnosis, grading, and reporting of cardiac antibody-mediated rejection.

18 Nov 2013

NanoViricides’ FluCide drug candidate found to be well tolerated in non-GLP safety/toxicology study

NanoViricides, Inc. (the "Company") reports that its optimized injectable FluCide® drug candidate was found to be well tolerated in a non-GLP small animal safety/toxicology study. This study is an important step in the drug development pathway for FluCide.

21 Oct 2013

Report alerts clinicians, public about catastrophic dangers of contaminated epidural injections

Investigators from the Centers for Disease Control and Prevention describe pathologic findings from 40 case reports of fungal infection in patients who had been given contaminated epidural, paraspinal, or intra-articular (into joints) steroid injections and correlate these findings with clinical and laboratory data.

26 Jun 2013

Six abstracts and clinical data on Cook Medical products to be presented at DDW 2013

At this week's Digestive Disease Week, the world's largest gathering of physicians and researchers in the gastroenterology field, six abstracts and other clinical data will be presented on Cook Medical products.

18 May 2013

Clinical data on Cook Medical products to be presented at Digestive Disease Week®

At this week’s Digestive Disease Week (DDW), the world’s largest gathering of physicians and researchers in the gastroenterology field, six abstracts and other clinical data will be presented on Cook Medical products. Cook’s EchoTip® ProCore™ High Definition Ultrasound Biopsy needles are featured in many of these presentations.

17 May 2013