Histopathology News and Research

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New AI tool 'TORCH' successfully identifies cancer origins in unknown primary cases

A deep-learning approach for tumor origin differentiation using cytological histology.

19 Apr 2024

Can synthetic data boost fairness in medical imaging AI?

A recent study in Nature Medicine demonstrates how diffusion models can enhance the robustness and fairness of medical machine learning models in interpreting medical images like histopathology, chest X-rays, and dermatological images by augmenting training datasets with synthetic data, improving accuracy and fairness across diverse patient groups.

11 Apr 2024

Researchers shed light on proteins controlling the development of ovaries in mice

Researchers at the Francis Crick Institute have shed light on the proteins controlling the development of ovaries in mice before and after birth.

22 Mar 2024

Advancing computational pathology with UNI and CONCH foundation models

Foundation models, advanced artificial intelligence systems trained on large-scale datasets, hold the potential to provide unprecedented advancements for the medical field.

19 Mar 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

Understanding how chikungunya virus affects the brain and body

The chikungunya virus, transmitted by Aedes aegypti and Aedes albopictus mosquitoes and responsible for more than 900 deaths in Brazil since it arrived around ten years ago, is capable of spreading through the blood, reaching multiple organs and crossing the blood-brain barrier, which protects the central nervous system.

12 Mar 2024

AI method can predict brain metastasis in lung cancer patients

Physicians treating patients with early-stage lung cancer face a conundrum: choosing potentially helpful yet toxic therapies such as chemotherapy, radiation or immunotherapy to knock out the cancer and lessen the risk of it spreading to the brain, or waiting to see if lung surgery alone proves sufficient.

11 Mar 2024

New catheter-based device images heart disease plaques with unprecedented detail

Researchers have developed a new catheter-based device that combines two powerful optical techniques to image the dangerous plaques that can build up inside the arteries that supply blood to the heart.

5 Mar 2024

Study addresses knowledge gap of clinical features and outcomes of Black patients with melanoma

Researchers identified patient- and tumor-level melanoma features in black individuals.

25 Jan 2024

New study reveals effective strategies against drug resistance in hospital-acquired pneumonia treatment

A novel rabbit infection model to investigate meropenem's resistance development.

23 Jan 2024

Prevention of post-menopausal osteoporosis in rats by sesame oil

Study demonstrates that daily supplementation with sesame oil in a rat model effectively prevents post-menopausal osteoporosis by maintaining serum estrogen and aromatase levels, suggesting its potential as a safer alternative to hormone replacement therapy.

4 Jan 2024

AI in healthcare: A double-edged sword? Study reveals impact on diagnostic accuracy

Study investigates the impact of AI on clinicians' diagnostic accuracy, revealing that AI explanations don't significantly mitigate the harmful effects of biased AI models, emphasizing the need for careful validation of AI tools in clinical settings.

19 Dec 2023

Study establishes iron accumulation as a driver of pathological senescence and fibrosis

Fibrosis is associated with various chronic and life-threatening conditions, including pulmonary fibrosis, liver cirrhosis, kidney disease, and cardiovascular diseases, among others.

14 Dec 2023

New insights into the cellular programs that promote resolution of inflammation during aging

Aging is associated with chronic, nonresolving inflammation, or "inflammaging," that can lead to tissue dysfunction.

6 Dec 2023

Study uses game theory to show low tumor heterogeneity leads to higher aggression

A study by the University of the Basque Country (UPV/EHU) uses game theory to establish that tumors with less cellular heterogeneity are more aggressive.

5 Dec 2023

Combining AI, ctDNA, and histopathology for improved treatment stratification in colorectal cancer

Combining artificial intelligence-generated digital pathology tools, conventional histopathological assessment and circulating tumor DNA (ctDNA) analysis can improve treatment stratification of patients with colorectal cancer after surgery.

1 Dec 2023

Fiber-free diet key to treating childhood Crohn's disease, new study finds

Research reveals how a fiber-free diet in Exclusive Enteral Nutrition (EEN) helps treat Crohn's disease in children by affecting the intestinal pathobiont Mucispirillum schaedleri. It shows that this diet alters gut microbiota, reducing Mucispirillum's pathogenicity and aiding in managing colitis.

26 Nov 2023

Study highlights glycolysis as a potential therapeutic target to combat Mycobacterium tuberculosis

It has been uncertain how Mycobacterium tuberculosis deflects the immune response in humans, though evidence has pointed to host immunometabolism -; the intrinsic link between metabolism in immune cells and their immune function.

20 Nov 2023

Fighting invisible foes: How cryptic fungal pathogens threaten human health and food security

The research paper in PLOS Pathogens delves into the challenges of diagnosing and treating cryptic fungal pathogens, which are difficult to distinguish from common fungi but equally dangerous. The study calls for more accurate diagnostic methods and a better understanding of how these fungi interact with the human immune system and microbiome for effective treatment and prevention.

25 Oct 2023

Canine transmission models provide insights into the neurological impacts of COVID-19 on human brains

The histopathologic alteration caused by SARS‑CoV‑2 on mammalian neurological systems.

20 Oct 2023