Homologous Recombination News and Research

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NICER: A safer alternative to CRISPR/Cas9 for gene editing

The gene editing technique CRISPR/Cas9 has allowed researchers to make precise and impactful changes to an organism's DNA to fix mutations that cause genetic disease.

15 Sep 2023

Long DNA molecules reveal new scar types in HR-deficient cancers

DNA can be damaged by toxins, radiation, or even normal cell division, but human cells must continually fix DNA breaks to survive.

16 Aug 2023

Study provides new insights into the mechanism of Dmc1 filament assembly

Homologous recombination (HR) is an important process that plays multiple crucial roles during meiosis, a type of cell cycle dedicated to sexual reproduction.

19 Jul 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

Elucidating the function of BRCA2 gene offers insight into cancer development

A new study shows exactly how the gene BRCA2, linked to susceptibility to breast and ovarian cancer, functions to repair damaged DNA.

3 Apr 2023

Researchers create a visualization of the full-length human BRCA2 protein at single molecule level

Using a self-built inverted microscope complete with laser optical tweezers to capture DNA, Yale Cancer Center and University of California Davis researchers for the first time created a visualization of the full-length human BRCA2 protein at the single molecule level.

31 Mar 2023

Study unveils a key factor involved in the DNA damage response and repair

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair.

8 Mar 2023

Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

In a recent study published in the Microorganisms journal, researchers in China reviewed the uses of bacterial-artificial-chromosome (BAC)-based genome editing techniques in herpesvirus research.

28 Feb 2023

New genetic test could guide the treatment of ovarian cancer

Researchers have developed an optimized genetic test for ovarian cancer, which helps accurately target an effective but expensive medication.

11 Jan 2023

New research on DNA-repair enzyme could help enhance cancer drug development

Researchers from Rice University and St. Jude Children's Research Hospital in Memphis, Tennessee, took a close look at one of ways cells repair broken strands of DNA and discovered details that could help make a particular enzyme a promising target for precision cancer therapy.

6 Jan 2023

New insights on the circadian clock of Drosophila melanogaster

The higher the temperatures, the faster physiological processes are. But there is an exception: the so-called circadian clock, which regulates the sleep-wake cycle in organisms.

30 Dec 2022

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

Scientists at the Francis Crick Institute, in collaboration with Artios, have identified how an enzyme involved in DNA repair (POLQ), becomes vital to the survival of certain cancers, if the cancer cells lose the ability to use a more common method of DNA repair.

30 Nov 2022

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

SOPHiA GENETICS, a cloud-native software company in the healthcare space, debuted new data at the European Society of Gynaecological Oncology (ESGO) Congress as part of a poster (#PA-065) presented by Prof. Alexandre Harlé of the Institut de Cancérologie de Lorraine, France.

3 Nov 2022

Homologous Recombination News and Research

NICER: A safer alternative to CRISPR/Cas9 for gene editing

Long DNA molecules reveal new scar types in HR-deficient cancers

Study provides new insights into the mechanism of Dmc1 filament assembly

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

Elucidating the function of BRCA2 gene offers insight into cancer development

Researchers create a visualization of the full-length human BRCA2 protein at single molecule level

Study unveils a key factor involved in the DNA damage response and repair

Genome editing techniques based on bacterial-artificial-chromosome in herpesvirus research

New genetic test could guide the treatment of ovarian cancer

New research on DNA-repair enzyme could help enhance cancer drug development

New insights on the circadian clock of Drosophila melanogaster

Scientists discover how an enzyme involved in DNA repair becomes vital to tumor survival

New evaluation data shows the clinical utility of SOPHiA DDM Dx HRD Solution

Researchers take a cue from viruses to make glioblastoma more vulnerable to treatment

Newly discovered gene marker may lead to a precision treatment for pancreatic cancer

Study finds telomeres can set damage thresholds for cancer cells above which they cannot continue to divide

Comparison of genome sequences of SARS-CoV-2 and other coronaviruses

Conceptual framework to examine the patterns of copy number alterations in human cancer

An Ad5 vectored COVID vaccine expressing an S1-N fusion protein

Research describes how DNA damage can affect neural health and function

Breaking Barriers: ANDYSMANCLUB's Fight for Men's Mental Health on World Mental Health Day

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

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