Homologous Recombination News and Research

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Scientists develop process for 'surgical' genetic changes

Research led by scientists at Iowa State University's Plant Sciences Institute has resulted in a process that will make genetic changes in plant genes much more efficient, practical and safe.

20 Jul 2009

New discovery on DNA repair mechanism

Researchers at Washington University School of Medicine in St. Louis have shed new light on a process that fixes breaks in the genetic material of the body's cells. Their findings could lead to ways of enhancing chemotherapy drugs that destroy cancer cells by damaging their DNA.

17 Jul 2009

Gene targeting discovery opens door for vaccines and drugs

In a genetic leap that could help fast track vaccine and drug development to prevent or tame serious global diseases, DMS researchers have discovered how to destroy a key DNA pathway in a wily and widespread human parasite.

13 Apr 2009

New methods for studying DNA repair and protein modification

This month's issue of Cold Spring Harbor Protocols features two articles detailing experimental methods for the analysis of molecular processes involved in DNA repair and post-translational modification of proteins.

5 Jan 2009

Real-time observation of the DNA-repair mechanism

For the first time, researchers at Delft University of Technology have witnessed the spontaneous repair of damage to DNA molecules in real time.

22 May 2008

Telepathic genes recognize similarities in each other

Genes have the ability to recognise similarities in each other from a distance, without any proteins or other biological molecules aiding the process, according to new research published this week in the Journal of Physical Chemistry B.

25 Jan 2008

Human RecQ helicases, homologous recombination and genomic instability

Two independent papers in the December 1st issue of G&D detail how human RecQ helicases regulate homologous recombination and protect genome stability.

15 Nov 2007

New technique to probe the dynamics of the Holliday junction

The Holliday junction is a four-stranded DNA structure that forms during a process known as homologous recombination, which occurs when damaged DNA is repaired. Understanding how DNA repairs itself is an essential step in ultimately developing therapies for genetic disorders.

17 Oct 2007

Enhanced DNA-repair mechanism can cause breast cancer

Although defects in the "breast cancer gene," BRCA1, have been known for years to increase the risk for breast cancer, exactly how it can lead to tumor growth has remained a mystery.

16 Oct 2007

RecA family recombinases repair DNA damages

A biochemistry research team led by Dr. Andrew H.-J. Wang and Dr. Ting-Fang Wang at the Institute of Biological Chemistry, Academia Sinica(IBCAS), has discovered that the RecA family recombinases function as a new type of rotary motor proteins to repair DNA damages.

13 Sep 2007

Embryonic stem cells can be created without eggs

Embryonic stem cells are unique because they can develop into virtually any kind of tissue type, an attribute called pluripotency.

8 Jun 2007

Environmentally damaged DNA may contribute to human genetic diversity

In this month's issue of the leading scientific journal Genome Research, scientists from Kyushu University report how environmentally damaged DNA may contribute to human genetic diversity.

2 May 2006

Method of gene therapy accurately corrects mutations in disease-causing genes

Harnessing the strength of a natural process that repairs damage to the human genome, a researcher from UT Southwestern Medical Center has helped establish a method of gene therapy that can accurately and permanently correct mutations in disease-causing genes.

5 Apr 2005

DNA repair kit announced by scientists

A study by scientists at Sangamo BioSciences, Inc. has demonstrated the use of the Company's zinc finger DNA-binding protein (ZFP) technology to achieve highly efficient, permanent correction of a disease-causing gene in primary human cells.

5 Apr 2005

Method of gene therapy that can accurately and permanently correct mutations in disease-causing genes

4 Apr 2005

New advances in sickle cell disease

Excruciating pain episodes, recurrent pneumonias, strokes, severe infections, chronic hemolytic anemia, and secondary pulmonary hypertension are common complications of sickle cell disease, a life-threatening inherited defect in blood that causes normally disc-shaped red blood cells to take on a sickle shape.

6 Dec 2004

New information on genetic shuffling before egg or sperm formation rewrites genetic theory

Key decisions in the genetic shuffling that occurs before eggs or sperm are formed are made earlier than thought, rewriting textbook genetics, according to recent papers from researchers at UC Davis, Harvard University and UC San Diego.

16 Apr 2004