Hypercholesterolemia News and Research

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Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.

People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). The abnormal buildup of cholesterol forms clumps (plaque) that narrow and harden artery walls. As the clumps get bigger, they can clog the arteries and restrict the flow of blood to the heart. The buildup of plaque in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack.

Inherited forms of hypercholesterolemia can also cause health problems related to the buildup of excess cholesterol in other tissues. If cholesterol accumulates in tendons, it causes characteristic growths called tendon xanthomas. These growths most often affect the Achilles tendons and tendons in the hands and fingers. Yellowish cholesterol deposits under the skin of the eyelids are known as xanthelasmata. Cholesterol can also accumulate at the edges of the clear, front surface of the eye (the cornea), leading to a gray-colored ring called an arcus cornealis.
Health screening and genetic tests may help detect people who carry a gene for familial hypercholesterolemia

Health screening and genetic tests may help detect people who carry a gene for familial hypercholesterolemia

Hypertensive disorders of pregnancy linked to CVD risk later in life

Hypertensive disorders of pregnancy linked to CVD risk later in life

Parents should know their children's cholesterol levels, expert says

Parents should know their children's cholesterol levels, expert says

More is better than less when it comes to physical activity and cardiovascular disease

More is better than less when it comes to physical activity and cardiovascular disease

Worsening brain function linked to deep anesthesia during surgery

Worsening brain function linked to deep anesthesia during surgery

Phenome study reveals alternate associations with SARS-CoV-2 risk loci

Phenome study reveals alternate associations with SARS-CoV-2 risk loci

BioIVT to highlight the use of SCHH model to investigate drug-drug interaction of bempedoic acid

BioIVT to highlight the use of SCHH model to investigate drug-drug interaction of bempedoic acid

Women with familial hypercholesterolemia miss out on active treatment because of pregnancy

Women with familial hypercholesterolemia miss out on active treatment because of pregnancy

Daily walnut consumption lowers LDL cholesterol levels and may promote cardiovascular health

Daily walnut consumption lowers LDL cholesterol levels and may promote cardiovascular health

AHA special issue focuses on health disparities among racial, ethnic communities

AHA special issue focuses on health disparities among racial, ethnic communities

Glycyrrhizic acid as a drug candidate for COVID-19

Glycyrrhizic acid as a drug candidate for COVID-19

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

COVID-19 increases heart attack rates in people with atherosclerotic cardiovascular disease

COVID-19 increases heart attack rates in people with atherosclerotic cardiovascular disease

Researchers use base editing to sustainably lower high LDL cholesterol levels

Researchers use base editing to sustainably lower high LDL cholesterol levels

A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection

A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection

Investigational drug reduced triglycerides in patients with severe hypertriglyceridemia, acute pancreatitis

Investigational drug reduced triglycerides in patients with severe hypertriglyceridemia, acute pancreatitis

Interaction between LDL cholesterol and PRS can predict risk of heart attack

Interaction between LDL cholesterol and PRS can predict risk of heart attack

Researchers develop new statistical method that generates significant genetic insights

Researchers develop new statistical method that generates significant genetic insights

New data highlights the gaps in care for children with familial hypercholesterolemia

New data highlights the gaps in care for children with familial hypercholesterolemia

Algorithm-driven program improves cholesterol, blood pressure levels

Algorithm-driven program improves cholesterol, blood pressure levels