Hypercholesterolemia News and Research

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Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.

People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). The abnormal buildup of cholesterol forms clumps (plaque) that narrow and harden artery walls. As the clumps get bigger, they can clog the arteries and restrict the flow of blood to the heart. The buildup of plaque in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack.

Inherited forms of hypercholesterolemia can also cause health problems related to the buildup of excess cholesterol in other tissues. If cholesterol accumulates in tendons, it causes characteristic growths called tendon xanthomas. These growths most often affect the Achilles tendons and tendons in the hands and fingers. Yellowish cholesterol deposits under the skin of the eyelids are known as xanthelasmata. Cholesterol can also accumulate at the edges of the clear, front surface of the eye (the cornea), leading to a gray-colored ring called an arcus cornealis.
Familial hypercholesterolemia patients are vulnerable for future heart and stroke events

Familial hypercholesterolemia patients are vulnerable for future heart and stroke events

People experienced more cardiovascular events when unable to obtain their LDL-cholesterol drug

People experienced more cardiovascular events when unable to obtain their LDL-cholesterol drug

Patients have higher risk of heart problems when insurance companies reject their prescriptions

Patients have higher risk of heart problems when insurance companies reject their prescriptions

A bacterium may limit cardiovascular risks of 1 in 2 people, study shows

A bacterium may limit cardiovascular risks of 1 in 2 people, study shows

Population-scale DNA test could make personalized medicine effective and affordable for all

Population-scale DNA test could make personalized medicine effective and affordable for all

Replacing a small amount of red meat with healthier foods may improve life expectancy

Replacing a small amount of red meat with healthier foods may improve life expectancy

Polygenic risk scores based on entire genome sequence may reliably predict heart disease

Polygenic risk scores based on entire genome sequence may reliably predict heart disease

Gender differences in manifestation of diseases lead to poorer diagnosis and treatment in women

Gender differences in manifestation of diseases lead to poorer diagnosis and treatment in women

Blood donations could hold clues to dangerous genetic cholesterol condition

Blood donations could hold clues to dangerous genetic cholesterol condition

Researchers evaluate risk factors and outcomes for young adults with familial hypercholesterolemia

Researchers evaluate risk factors and outcomes for young adults with familial hypercholesterolemia

Statins provide no benefit for 50 percent of patients, say researchers

Statins provide no benefit for 50 percent of patients, say researchers

Pregnancy history may be linked to cognitive function in older women, finds study

Pregnancy history may be linked to cognitive function in older women, finds study

A new option for reducing LDL cholesterol in patients at high risk for heart attack, stroke

A new option for reducing LDL cholesterol in patients at high risk for heart attack, stroke

Success for new cholesterol-lowering drug

Success for new cholesterol-lowering drug

Study finds low rates of lipid screening among women of childbearing age

Study finds low rates of lipid screening among women of childbearing age

Obesity and severe obesity added as risk factors for premature heart disease in children

Obesity and severe obesity added as risk factors for premature heart disease in children

Researchers show how mechanical stress affects bone development

Researchers show how mechanical stress affects bone development

Scientists cast new light on function of long-mysterious PCSK9 mutation

Scientists cast new light on function of long-mysterious PCSK9 mutation

Study finds elevated cholesterol levels after Christmas break

Study finds elevated cholesterol levels after Christmas break

Study: Cholesterol uptake is decreased in GM3S-deficient cells

Study: Cholesterol uptake is decreased in GM3S-deficient cells