Hypercholesterolemia News and Research

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Hypercholesterolemia is a condition characterized by very high levels of cholesterol in the blood. Cholesterol is a waxy, fat-like substance that is produced in the body and obtained from foods that come from animals (particularly egg yolks, meat, poultry, fish, and dairy products). The body needs this substance to build cell membranes, make certain hormones, and produce compounds that aid in fat digestion. Too much cholesterol, however, increases a person's risk of developing heart disease.

People with hypercholesterolemia have a high risk of developing a form of heart disease called coronary artery disease. This condition occurs when excess cholesterol in the bloodstream is deposited in the walls of blood vessels, particularly in the arteries that supply blood to the heart (coronary arteries). The abnormal buildup of cholesterol forms clumps (plaque) that narrow and harden artery walls. As the clumps get bigger, they can clog the arteries and restrict the flow of blood to the heart. The buildup of plaque in coronary arteries causes a form of chest pain called angina and greatly increases a person's risk of having a heart attack.

Inherited forms of hypercholesterolemia can also cause health problems related to the buildup of excess cholesterol in other tissues. If cholesterol accumulates in tendons, it causes characteristic growths called tendon xanthomas. These growths most often affect the Achilles tendons and tendons in the hands and fingers. Yellowish cholesterol deposits under the skin of the eyelids are known as xanthelasmata. Cholesterol can also accumulate at the edges of the clear, front surface of the eye (the cornea), leading to a gray-colored ring called an arcus cornealis.
Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

Overexpression of PGC1 in vascular smooth muscle cells ameliorates atherosclerosis

COVID-19 increases heart attack rates in people with atherosclerotic cardiovascular disease

COVID-19 increases heart attack rates in people with atherosclerotic cardiovascular disease

Researchers use base editing to sustainably lower high LDL cholesterol levels

Researchers use base editing to sustainably lower high LDL cholesterol levels

A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection

A study reports the first case of an upper extremity deep vein thrombosis (DVT) recurrence due to COVID-19 infection

Investigational drug reduced triglycerides in patients with severe hypertriglyceridemia, acute pancreatitis

Investigational drug reduced triglycerides in patients with severe hypertriglyceridemia, acute pancreatitis

Interaction between LDL cholesterol and PRS can predict risk of heart attack

Interaction between LDL cholesterol and PRS can predict risk of heart attack

Researchers develop new statistical method that generates significant genetic insights

Researchers develop new statistical method that generates significant genetic insights

New data highlights the gaps in care for children with familial hypercholesterolemia

New data highlights the gaps in care for children with familial hypercholesterolemia

Algorithm-driven program improves cholesterol, blood pressure levels

Algorithm-driven program improves cholesterol, blood pressure levels

New drug reduces LDL cholesterol in patients with severe hypercholesterolemia

New drug reduces LDL cholesterol in patients with severe hypercholesterolemia

Research indicates increased breast cancer mortality in African American and Black survivors

Research indicates increased breast cancer mortality in African American and Black survivors

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Gruthan Bioscience to develop new class of cholesterol-lowering drugs

Study shows why certain genetically predisposed individuals do not develop heart disease

Study shows why certain genetically predisposed individuals do not develop heart disease

Population screening has potential to identify individuals at risk for inherited genetic conditions

Population screening has potential to identify individuals at risk for inherited genetic conditions

Genetic testing can help make well-informed decisions about heart health

Genetic testing can help make well-informed decisions about heart health

More than half of American children lack cardiorespiratory fitness

More than half of American children lack cardiorespiratory fitness

Selective statins may reduce SARS-CoV-2 cell entry and inhibit infection

Selective statins may reduce SARS-CoV-2 cell entry and inhibit infection

GlobalData: Diagnosed prevalent cases of angina pectoris expected to reach 22.79 million in 2028

GlobalData: Diagnosed prevalent cases of angina pectoris expected to reach 22.79 million in 2028

Individuals with high risk of cancer and CVD cannot be identified based on family history

Individuals with high risk of cancer and CVD cannot be identified based on family history

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder

Evinacumab drug reduces cholesterol levels in patients with rare cholesterol disorder