Hypoxic Ischemic Encephalopathy News and Research

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Patients facing death are opting for a lifesaving heart device — but at what risk?

Too old and too sick for a heart transplant, Arvid Herrman was given a choice: Have a mechanical pump implanted in his heart, potentially keeping him alive for several years, or do nothing and almost certainly die within a year.

19 Dec 2023

Case study shows how COVID-19 breached the placenta and caused brain damage in the baby

Researchers at UHealth-;the University of Miami Health System and the University of Miami Miller School of Medicine have shown that, in two cases, COVID-19 infection breached the placenta and caused brain damage in the newborn.

6 Apr 2023

Umbilical cord milking may be safe, more effective for non-vigorous term and near- term infants

A treatment to move blood from the umbilical cord into an infant's body may improve the overall health of newborns classified as non-vigorous—limp, pale and with minimal breathing, suggests a study funded by the National Institutes of Health.

7 Sep 2022

Adding erythropoietin to cooling therapy shows no added benefits for newborns with birth asphyxia

Adding erythropoietin to cooling therapy for term newborns with birth asphyxia has no benefit over cooling therapy alone, a study published today in the New England Journal of Medicine.

14 Jul 2022

Researchers report a key breakthrough to help protect newborns from brain damage

Oxygen deprivation can be the worst start to a newborn's life, resulting in brain damage, epilepsy, developmental delays and death.

23 Jun 2020

Minimally invasive technique to directly measure cardiac output in newborns

The amount of blood that the heart pumps in one minute (cardiac output) can be directly measured safely in newborns by monitoring changes in blood velocity after injecting saline, indicates a paper published online Dec. 17, 2019 in the Journal of Pediatrics and Neonatal Medicine.

8 Jan 2020

Measuring biomarkers in blood may help pinpoint newborns with HIE

Measuring a number of biomarkers over time that are produced as the body responds to inflammation and injury may help to pinpoint newborns who are more vulnerable to suffering lasting brain injury due to disrupted oxygen delivery and blood flow, according to research presented during the Pediatric Academic Societies 2019 Annual Meeting.

27 Apr 2019

Lower heart rate variability linked to autonomic manifestations of stress in newborns with HIE

In newborns with hypoxic-ischemic encephalopathy, lower heart rate variability correlates with autonomic manifestations of stress shortly after birth, underscoring the value of this biomarker, according to Children's research presented during the Pediatric Academic Societies 2019 Annual Meeting.

27 Apr 2019

New study aims to determine underlying etiology of seizures and reduce morbidities in children

A new study aims to determine the underlying etiology of seizures and help to target therapy, improve control of seizures, and potentially reduce morbidities in children.

27 Apr 2019

New study reveals potential benefits of cEEG monitoring for infant ICU patients

A recent retrospective study evaluating continuous electroencephalography of children in intensive care units found a higher than anticipated number of seizures.

13 Dec 2018

Thalamus controls development of normal sleep and waking states, study finds

Consciousness requires continuous, internally generated activity in the brain. The modulation of this activity is the basis of the electroencephalogram (EEG) and of generation of sleep, dreams, and perception.

12 Oct 2018

Study finds narrowed upper airways in preterm infants that may explain higher OSA risk

Infants born preterm have significantly lower nasopharyngeal and oropharyngeal volumes, compared with newborn peers carried to full term, and those lower airway volumes are independent of the infants' gender, ethnicity or weight, according to a study published online Dec. 16, 2017 in Clinical Imaging.

22 Dec 2017

Study uses NHS data to estimate incidence of brain injury in babies

New research has estimated that each year five babies in every 1,000 born in England suffer a condition or sign linked to brain injury.

28 Nov 2017

Compact broadband NIRS system offers safe, non-invasive way to monitor newborn brain function

Multimodal-Spectroscopy research team in the Biomedical Optics Research Laboratory at the Medical Physics and Biomedical Engineering department at University College London led by Dr IliasTachtsidis has designed CYRIL, a compact broadband near-infrared spectroscopy(NIRS) system, to monitor brain tissue physiology non-invasively in newborn babies.

15 Nov 2017

Continuous EEG can be more reliable way to identify infants at risk for brain injury

Continuously recording the brain's electrical signals and examining how those impulses evolve over time is a more reliable way to identify infants at risk for brain injury, compared with doing snapshot evaluations, according to a prospective cohort study led by Children's National Health System research-clinicians.

25 Oct 2017

Researchers work toward developing better definition of neonatal acute kidney injury

Each year, thousands of infants in the United States end up in neonatal intensive care units with acute kidney injury (AKI), a condition in which the kidneys falter in performing the critical role of filtering waste products and excess fluid from the blood to produce urine.

10 Aug 2017

Study determines safest temperature and duration for body-cooling of newborns

After more than 20 years of research on the best treatment for full-term infants affected by oxygen deprivation during the birthing process, Seetha Shankaran, M.D., neonatologist at DMC's Children's Hospital of Michigan and Hutzel Women's Hospital, served as the lead investigator in a definitive Journal of the American Medical Association study that documented the safest depth and duration of body-cooling to minimize injury from hypoxic ischemic encephalopathy (HIE) in newborns.

25 Jul 2017

Advances in NIRS technologies offer reduced health-care costs, better patient comfort

The latest advances in near-infrared spectroscopy technologies are enabling development of new capabilities in diagnosis and treatment of disease, offering reduced health-care costs, portability, increased sensitivity, higher patient comfort, and better quality of life.

21 Jul 2016

Study confirms neuroprotective effects of hypothermia in newborns with HIE

A unique study at Children's Hospital Los Angeles of newborns treated with hypothermia for hypoxic-ischemic encephalopathy (HIE) - a condition that occurs when the brain is deprived of an adequate oxygen supply - confirms its neuroprotective effects on the brain.

9 Oct 2015

Deeper cooling does not reduce NICU death among newborns with hypoxic ischemic encephalopathy

Among full-term newborns with moderate or severe hypoxic ischemic encephalopathy (damage to cells in the central nervous system from inadequate oxygen), receiving deeper or longer duration cooling did not reduce risk of neonatal intensive care unit death, compared to usual care, according to a study in the December 24/31 issue of JAMA.

24 Dec 2014

Hypoxic Ischemic Encephalopathy News and Research

Patients facing death are opting for a lifesaving heart device — but at what risk?

Case study shows how COVID-19 breached the placenta and caused brain damage in the baby

Umbilical cord milking may be safe, more effective for non-vigorous term and near- term infants

Adding erythropoietin to cooling therapy shows no added benefits for newborns with birth asphyxia

Researchers report a key breakthrough to help protect newborns from brain damage

Minimally invasive technique to directly measure cardiac output in newborns

Measuring biomarkers in blood may help pinpoint newborns with HIE

Lower heart rate variability linked to autonomic manifestations of stress in newborns with HIE

New study aims to determine underlying etiology of seizures and reduce morbidities in children

New study reveals potential benefits of cEEG monitoring for infant ICU patients

Thalamus controls development of normal sleep and waking states, study finds

Study finds narrowed upper airways in preterm infants that may explain higher OSA risk

Study uses NHS data to estimate incidence of brain injury in babies

Compact broadband NIRS system offers safe, non-invasive way to monitor newborn brain function

Continuous EEG can be more reliable way to identify infants at risk for brain injury

Researchers work toward developing better definition of neonatal acute kidney injury

Study determines safest temperature and duration for body-cooling of newborns

Advances in NIRS technologies offer reduced health-care costs, better patient comfort

Study confirms neuroprotective effects of hypothermia in newborns with HIE

Deeper cooling does not reduce NICU death among newborns with hypoxic ischemic encephalopathy

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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