Immune System News and Research

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Phase 1/2 clinical trial data of Oncophage for recurrent high-grade glioma

Antigenics today announced that data from a multi-center Phase 1/2 clinical trial of Oncophage (vitespen) for recurrent high-grade glioma (brain cancer) was presented at the International Conference on Brain Tumor Research and Therapy. The study was conducted by the Brain Tumor Research Center at the University of California, San Francisco.

20 May 2010

Research and movement in future towards universal influenza virus vaccine

Researchers at Mt. Sinai School of Medicine have developed a novel influenza vaccine that could represent the next step towards a universal influenza vaccine eliminating the need for seasonal immunizations. They report their findings today in the inaugural issue of mBio-, the first online, open-access journal published by the American Society for Microbiology.

20 May 2010

Recruitment of children and adults with type 1 diabetes commences in Protege Encore teplizumab trial

Dr. Barry Reiner announced that he is now recruiting children and adults with newly diagnosed type 1 diabetes for Protege Encore, a randomized, placebo-controlled Phase III clinical trial. This is the second of two Phase III studies testing the safety and efficacy of an investigational drug called teplizumab. The first study, known as Protege, has completed enrollment of more than 530 subjects with type 1 diabetes. There is currently no approved therapy to slow the progression of type 1 diabetes.

20 May 2010

Live malaria parasites in the skin shut down immune responses and block vaccine function: Study

Why one after another new malaria vaccine tests well in the laboratory but fails in field trials has frustrated legions of malaria researchers, and has been the main stumbling block to malaria eradication. Now, a research team from Germany has unraveled that puzzle and shown that the problem is all about the skin and how it controls the immune system. The implications are profound.

20 May 2010

Update on Phase I clinical trials of Oncopore for treatment of cancer

The Norwegian pharmaceutical company Lytix Biopharma AS provided an update at the recent BIO conference in Chicago on Phase I clinical trials of Oncopore (LTX-315) for the treatment of cancer.

20 May 2010

Saint Louis University conducts research to find safe, effective vaccination for dengue

Sponsored by the National Institutes of Health, Saint Louis University's Center for Vaccine Development is conducting research of an investigational vaccine designed to prevent people from contracting dengue, a potentially lethal virus that has rapidly spread around the world.

20 May 2010

New study shows CDPK1 controls toxoplasma's ability to secrete microneme proteins

Researchers at Washington University School of Medicine in St. Louis have identified a parasite protein that has all the makings of a microbial glass jaw: it's essential, it's vulnerable and humans have nothing like it, meaning scientists can take pharmacological swings at it with minimal fear of collateral damage.

20 May 2010

Zebrafish may help scientists reveal function of mysterious enzyme linked to steroid cortisol

Michael E. Baker, PhD, a researcher at the University of California, San Diego School of Medicine has discovered that zebrafish - an important animal model in disease and environmental studies - could provide the means to help scientists eventually reveal the function of a mysterious enzyme linked to the steroid cortisol, and found in the human brain.

20 May 2010

Kansas State University researcher awarded NIH grant to study antibiotic-resistant bacteria

Antibiotic-resistant bacteria are becoming a growing problem around the world, and are a particular worry in hospital-acquired infections.

20 May 2010

Inviragen initiates first clinical trial of DENVax vaccine to protect against dengue fever

Inviragen has announced the initiation of the first clinical trial of its vaccine to protect against dengue fever. The trial, to be conducted at Saint Louis University, is designed to assess the safety of Inviragen's investigational dengue vaccine.

20 May 2010

Phase I study of SNS-032 demonstrates safety, potential clinical activity in treating B-cell malignancies

A Phase I clinical trial of SNS-032, one of the first in a new class of drugs that inhibit cyclin-dependent kinases, demonstrated the drug's safety and potential clinical action against advanced chronic lymphocytic leukemia. Cyclin-dependent kinases are enzymatic proteins that are integrally involved in cellular metabolism, renewal and signaling, and are thought to play key roles in the growth of cancers.

20 May 2010

NeoStem, Vatican's Pontifical Council collaborate to expand raise awareness of adult stem cell therapies

NeoStem, Inc.,, an international biopharmaceutical company with operations in the US and China, and the Vatican's Pontifical Council for Culture, today announced a joint initiative that includes their charitable organizations to expand research and raise awareness of adult stem cell therapies.

19 May 2010

Vaccinations recommended for adults

Yearly vaccinations aren't just for kids any more. You probably heard a lot about a seasonal or H1N1 flu shot last fall, but you should know that a battery of other adult vaccinations might also become part of your health care routine. Pneumonia and shingles vaccines are preventive-care essentials for older adults, and meningitis and tetanus shots are now college rites of passage. Even the vaccines of childhood—measles, mumps and rubella, and whooping cough—are recommended for adults who missed out in their younger years.

19 May 2010

PET scanning provides great insight into immune response

A commonly used probe for Positron Emission Tomography scanning and a new probe developed by researchers at UCLA reveal different functions in diverse cells of the immune system, providing a non-invasive and much clearer picture of an immune response in action.

19 May 2010

Newly-discovered watchmen DCs instruct T cells to attack and destroy cancer cells

Cancer Research UK scientists have discovered sophisticated 'watchman' cells in humans that can instruct the immune system to destroy foreign invaders like viruses and cancer cells, according to research published in The Journal of Experimental Medicine.

19 May 2010

Molecular Devices' foundational planar patch-clamp patent upheld by European Patent Office

Molecular Devices today announced that European Patent Office (EPO) has upheld Molecular Devices foundational planar patch-clamp patent (EP No 1 040 349 B1). The board will issue a written decision to this effect in the near future. The ruling will be the final determination of the EPO and cannot be appealed.

19 May 2010

Cincinnati Children's Hospital Medical Center launches REGID

A new nationwide registry will allow researchers to conduct larger, more effective studies of often misdiagnosed disorders that affect thousands of children in the United States.

19 May 2010

Researchers discover biological pathway signature of ccRCC

By examining expression of every human gene in clear cell renal cell carcinoma compared to normal kidney cells, researchers at Mayo Clinic's campus in Florida have discovered gene signatures they say explain much of the biology of this common and difficult-to-treat kidney cancer.

19 May 2010

WPI, Cerus announce positive results from study of INTERCEPT Blood System to inactivate XMRV

The Whittemore Peterson Institute for Neuro-Immune Disease (WPI) and Cerus Corporation announced positive results from a study demonstrating the efficacy of the INTERCEPT Blood System to inactivate XMRV, a human retrovirus, in donated platelet components.

18 May 2010

Tengion reports net loss attributable to common stockholders of $14.33 per share for first-quarter 2010

Tengion Inc. today reported its financial results for the quarter ended March 31, 2010 and provided a corporate and clinical development update.

18 May 2010

Immune System News and Research

Phase 1/2 clinical trial data of Oncophage for recurrent high-grade glioma

Research and movement in future towards universal influenza virus vaccine

Recruitment of children and adults with type 1 diabetes commences in Protege Encore teplizumab trial

Live malaria parasites in the skin shut down immune responses and block vaccine function: Study

Update on Phase I clinical trials of Oncopore for treatment of cancer

Saint Louis University conducts research to find safe, effective vaccination for dengue

New study shows CDPK1 controls toxoplasma's ability to secrete microneme proteins

Zebrafish may help scientists reveal function of mysterious enzyme linked to steroid cortisol

Kansas State University researcher awarded NIH grant to study antibiotic-resistant bacteria

Inviragen initiates first clinical trial of DENVax vaccine to protect against dengue fever

Phase I study of SNS-032 demonstrates safety, potential clinical activity in treating B-cell malignancies

NeoStem, Vatican's Pontifical Council collaborate to expand raise awareness of adult stem cell therapies

Vaccinations recommended for adults

PET scanning provides great insight into immune response

Newly-discovered watchmen DCs instruct T cells to attack and destroy cancer cells

Molecular Devices' foundational planar patch-clamp patent upheld by European Patent Office

Cincinnati Children's Hospital Medical Center launches REGID

Researchers discover biological pathway signature of ccRCC

WPI, Cerus announce positive results from study of INTERCEPT Blood System to inactivate XMRV

Tengion reports net loss attributable to common stockholders of $14.33 per share for first-quarter 2010

Immunology eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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