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Pfizer-BioNTech COVID-19 vaccine effective in patients with myeloproliferative neoplasms

Researchers in the UK have provided evidence that Pfizer-BioNTech’s coronavirus disease 2019 (COVID-19) vaccine induces effective immune responses in patients with myeloproliferative neoplasms.

13 May 2021

New publication details strengths and weaknesses of the U.S. health insurance system

A landmark work that details the strengths and weaknesses of the U.S. health insurance system, including how it lags behind those of other wealthy countries in measures that include mortality from both preventable and treatable causes, has been published.

12 May 2021

T cell populations in nasal mucosa expand after COVID-19 mRNA vaccination

A new study released as a bioRxiv* preprint tried to establish how tissues such as the upper respiratory tract (URT) – which harbor the virus and often act as the point of entry – are difficult to access for routine testing, but are responsive to vaccination.

11 May 2021

Experimental gene therapy successfully treats children born without an immune system

An experimental form of gene therapy developed by a team of researchers from UCLA and Great Ormond Street Hospital in London has successfully treated 48 of 50 children born with a rare and deadly inherited disorder that leaves them without an immune system.

11 May 2021

Case study describes consequences of undetected SARS-CoV-2 infection during mRNA vaccination

Now, a new report describes a case of a coincidental mRNA vaccination and SARS-CoV-2 infection in a 31-year-old doctor, addressing the theoretical considerations for potential risks and further required actions in case more cases appear in the future.

11 May 2021

3D printing technique extends the possibilities of lateral flow tests

Researchers at KU Leuven (Belgium) have developed a 3D printing technique that extends the possibilities of lateral flow testing.

10 May 2021

Prevalence of SARS-CoV-2 antibodies in Germany

Seroprevalence studies have proved their worth in estimating the size and directionality of an outbreak of infectious disease, especially the current pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced coronavirus disease 2019 (COVID-19). A new study posted to the medRxiv* preprint server describes the prevalence of SARS-CoV-2 antibodies in five representative regions of Germany.

10 May 2021

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

An interesting new study describes the emergence of several such variants from a chronically immunosuppressed COVID-19 patient, who remained infected for over 170 days before clearing the virus.

7 May 2021

Transplant recipients with COVID-19 may show lower cellular and antibody immune responses

Transplant patients are typically on chronic immunosuppression, making them automatically more vulnerable to infection with SARS-CoV-2, the agent responsible for the loss of over three million lives in the current COVID-19 pandemic. A new study discusses evidence for subnormal immune responses following COVID-19 in this population.

6 May 2021

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

In a new study recently published in the journal Science, a team of researchers in the U.S. found that most of the antibodies circulating in the blood target areas of the viral spike protein outside the receptor-binding domain (RBD), the part of the spike that binds directly to human cell receptors.

6 May 2021

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Last year, Charles O. Elson, M.D., demonstrated a potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease. He used a mouse model that included immune-reactive T cells from patients with Crohn's disease in a flagellin peptide-specific immunotherapy.

6 May 2021

Robust passive and active immunity found in infants born to COVID-19 positive mothers

A new study provides evidence that babies born to mothers who were COVID-19 positive two or more months before delivery are protected by maternal antibodies, besides mounting a robust immune response in case they contract the infection in the perinatal period.

5 May 2021

Pregnancy may increase the risk of COVID-19 severity

Against the background of the COVID-19 pandemic, the impact of SARS-CoV-2 infection in pregnancy has been a subject of much controversy. In order to help answer the question as to whether this infection causes significant harm in pregnancy, a new study, released as a medRxiv* preprint, reports on the disease outcomes of this infection in pregnant women.

5 May 2021

Monoclonal antibody neutralizes all SARS-CoV-2 variants of concern

Researchers in Canada and the United States have identified a monoclonal antibody that potently neutralizes variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the ongoing coronavirus disease 2019 (COVIdD-19) pandemic.

3 May 2021

COVID-19 may not have appeared first in China, suggests new genomic study

A new study in Acta Mathematica Scientia suggests that the virus may have originated in multiple countries almost simultaneously, rather than spreading from China to the rest of the world.

3 May 2021

Recovered COVID-19 patients show signs of long-term immunity

A study conducted by researchers in the United States has found that most patients who recovered from coronavirus disease 2019 (COVID-19) showed signs of long-lasting immunity against the causative agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

28 Apr 2021

Real-world study in India finds COVISHIELD vaccine safe and effective

New research led by Naresh Trehan of Medanta-The Medicity in India found the COVISHIELD (ChAdOx1 nCoV-19 Corona Virus Vaccine) vaccine produced an immune response from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) two weeks after vaccination with limited side effects.

26 Apr 2021

Study focuses on SARS-CoV-2 antibody seroprevalence in Wuhan and COVID-19 controls

Since the emergence in December 2019 in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide via transmission among close human contacts. Early on, several public health interventions were implemented in Wuhan city and Hubei Province, including lockdowns, social distancing, traffic restrictions, stay-at-home policies, face mask requirements, building temporary hospitals, and centralized quarantine. There were 50,355 confirmed cases of SARS-CoV-2 infection in Wuhan as of 28 January 2021.

25 Apr 2021

Single dose of Pfizer-BioNTech COVID-19 vaccine induces immunity in CML patients

Researchers in the UK have shown that a single dose of the Pfizer-BioNTech vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced antibody and cellular responses in patients with chronic myeloid leukemia (CML) who were taking tyrosine kinase inhibitors.

25 Apr 2021

NIAID establishes a clinical research network to improve understanding of childhood asthma

The National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, has awarded $10 million in first-year funding to establish a clinical research network called Childhood Asthma in Urban Settings (CAUSE).

23 Apr 2021

Immunoglobulin News and Research

Pfizer-BioNTech COVID-19 vaccine effective in patients with myeloproliferative neoplasms

New publication details strengths and weaknesses of the U.S. health insurance system

T cell populations in nasal mucosa expand after COVID-19 mRNA vaccination

Experimental gene therapy successfully treats children born without an immune system

Case study describes consequences of undetected SARS-CoV-2 infection during mRNA vaccination

3D printing technique extends the possibilities of lateral flow tests

Prevalence of SARS-CoV-2 antibodies in Germany

Immunosuppression in COVID-19 promotes emergence of multiple immune escape mutants

Transplant recipients with COVID-19 may show lower cellular and antibody immune responses

About 84% of antibodies in plasma target non-RBD epitopes on SARS-CoV-2 spike protein, finds study

Study describes IgG antibodies in Crohn's disease specific for human bacterial flagellins

Robust passive and active immunity found in infants born to COVID-19 positive mothers

Pregnancy may increase the risk of COVID-19 severity

Monoclonal antibody neutralizes all SARS-CoV-2 variants of concern

COVID-19 may not have appeared first in China, suggests new genomic study

Recovered COVID-19 patients show signs of long-term immunity

Real-world study in India finds COVISHIELD vaccine safe and effective

Study focuses on SARS-CoV-2 antibody seroprevalence in Wuhan and COVID-19 controls

Single dose of Pfizer-BioNTech COVID-19 vaccine induces immunity in CML patients

NIAID establishes a clinical research network to improve understanding of childhood asthma

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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