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Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

Researchers pursued evidence of whether the interaction between the patatin-like phospholipase domain-containing 3 p.I148M variant and the female sex at the genetic and molecular level explains why premenopausal women remain protected against fatty liver disease, while a rapidly progressive disease ensues in some peri- and postmenopausal women.

28 Sep 2023

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

New research in JAMA finds a temporal association between SARS-CoV-2 infections and the onset of islet autoimmunity, a precursor to type 1 diabetes, in genetically predisposed infants. The study underscores COVID-19 as a potential risk factor for the development of this form of diabetes in young children.

13 Sep 2023

Arf1 inhibition induces tumor regression by promoting T cell infiltration

In recent years, cancer immunotherapies, represented by immune checkpoint blockade (ICB), have been highly successful and have become an important basis for the future treatment of cancers.

12 Sep 2023

Study evaluates differences in humoral immune response against SARS-CoV-2 in infants versus mothers

Researchers comparatively evaluated humoral immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among infants and their mothers.

16 Aug 2023

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

Researchers used a multidisciplinary approach to investigate a nonstructural protein essential in SARS-CoV-2 replication.

10 Aug 2023

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study described a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) that selectively kills cancer cells.

4 Aug 2023

Study discloses vital role of LINC00901 and its regulatory network in pancreatic cancer progression

Chemical modifications of RNA molecules, such as m6A, can critically impact gene expression, influencing various aspects of cancer development and progression.

4 Aug 2023

The essential role of the MPL36 protein in leptospirosis

The Leptospira membrane protein L36 (MPL36) is essential for its pathogenesis.

31 Jul 2023

Researchers discover new way to target bacterial cell wall

The bacterial cell wall must be constantly remodeled in order to grow and divide. This involves the close coordination of lytic enzymes and peptidoglycan synthesis.

20 Jul 2023

New research shows antibody cross-reactivity between human and animal coronaviruses

Researchers probed for antibody binding against all seven human coronaviruses (hCoVs).

27 Jun 2023

MIS-C in children: A distinct autoimmune response to COVID-19 unveiled

The study reveals that MIS-C patients, post SARS-CoV-2 infection, develop a unique immune response against the virus' N protein, indicating a cross-reactivity with the self-protein SNX8, which might link the infection to the ensuing inflammatory syndrome.

8 Jun 2023

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Stress granules sequester Alzheimer's disease-associated gene transcripts and regulate disease-related neuronal proteostasis."

1 Jun 2023

Novel assay for identifying individuals with synucleinopathies using serum samples

Synucleinopathies are a group of neurodegenerative diseases caused by the abnormal accumulation α-synuclein, a protein normally found in the brain and neurons. Incorrect folding of α-synuclein leads to formation of 'seeds', which attract more α-synuclein proteins to form larger clumps.

29 May 2023

Immunoprecipitation News and Research

Fatty liver disease susceptibility: study identifies interaction between estrogen receptor and genetic variant in women

COVID-19 doubles risk of early type 1 diabetes signs in high-risk children

Arf1 inhibition induces tumor regression by promoting T cell infiltration

Study evaluates differences in humoral immune response against SARS-CoV-2 in infants versus mothers

Newly identified helicase might hold the key to a novel family of anti-COVID-19 drugs

New PCNA inhibitor AOH1996 shows selective cancer cell killings and tumor suppression potential

Study discloses vital role of LINC00901 and its regulatory network in pancreatic cancer progression

The essential role of the MPL36 protein in leptospirosis

Researchers discover new way to target bacterial cell wall

New research shows antibody cross-reactivity between human and animal coronaviruses

MIS-C in children: A distinct autoimmune response to COVID-19 unveiled

RNA regulatory mechanism could be targeted to slow AD progression mediated by stress granules

Novel assay for identifying individuals with synucleinopathies using serum samples

GPR141 drives breast tumorigenesis by inducing tumor cell properties via the p-mTOR1/p53 axis

Research provides new insights into the underlying disease mechanisms for polycystic kidney disease

Epigenome reprogramming after SARS-CoV-2 infection

Menin protein protects against aging and cognitive decline

Monoclonal antibody-based blocking ELISA for SARS-CoV-2 detection in animals

Interferon autoantibodies not implicated in long-COVID

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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