Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Letermovir: A promising breakthrough in CMV prevention for kidney transplant recipients

In a recent article published in the journal JAMA Network, researchers performed a randomized clinical trial (RCT) to demonstrate the noninferiority of letermovir vs. valganciclovir for prophylaxis of cytomegalovirus (CMV) in adult CMV-seronegative kidney transplant recipients (KTRs) who received a kidney from a CMV-seropositive individual.

13 Jun 2023

Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Two new studies in Science and Science Immunology spotlight a group of intestinal T cells with α4β7 integrin receptors that could be targeted to prevent resistance to immune checkpoint blockade (ICB) cancer immunotherapy.

8 Jun 2023

Cost of prescription drugs to the NHS reached a new high in the financial year 2021 -2022, says LSE report

New figures show that the total cost of prescription medicines to the NHS in England reached a new high of £17.2 billion in the financial year 2021 -2022, according to a new independent report by the London School of Economics and Political Science (LSE), the London School of Hygiene & Tropical Medicine and the University of York.

4 Jun 2023

Severe COVID-19 raises alarm for undiagnosed cancer

Severe SARS-CoV-2 infection is associated with a 1.31 higher risk of being diagnosed with cancer following hospital discharge, particularly renal, hematological, colon, and lung cancers, suggesting a potential link between the infection and undiagnosed cancer.

1 Jun 2023

Adoption of Mediterranean diet shows promise in easing symptoms for myeloproliferative neoplasm patients

Researchers assess the feasibility of an education-focused Mediterranean diet intervention among myeloproliferative neoplasm patients.

25 May 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

Comparing clinical characteristics and outcomes of critically ill COVID-19 patients with a chohort admitted to ICU for influenza pneumonia

A recent study evaluated clinical differences between critically ill COVID-19 and influenza patients.

19 May 2023

Exploiting platelets for antitumor drug delivery and immune modulation of tumor microenvironment

Announcing a new publication for Acta Materia Medica journal. Platelets are blood components traditionally believed to have fundamental roles in vascular hemostasis and thrombosis.

15 May 2023

Analyzing impact of phospholipase D on the host immune response to A. fumigatus infection

Announcing a new article publication for Zoonoses journal. Aspergillus fumigatus infection in the lungs is accompanied by the recruitment of innate immune cells, phagocytosis, and the release of inflammatory factors.

11 May 2023

Nirmatrelvir/ritonavir reduces the risk of COVID-19-associated hospitalization

Researchers assess whether nirmatrelvir/ritonavir treatment reduced the risk of COVID-19-related hospitalization.

10 May 2023

Breast cancer tumors disrupt the development of an immune response to favor their own growth

Researchers at Baylor College of Medicine and collaborating institutions have identified a strategy cancerous tumors use to remotely disrupt the development of an immune response that could stop their growth.

5 May 2023

Smoking alters lung microbiome, leading to loss of diversity and community structure

Research investigates the impact of smoking on the lower respiratory tract microbiome. The study found that smoking results in a loss of diversity in the microbiome, changes in co-occurrence patterns, and a weakening of the tight community structure present in healthy microbiomes.

26 Apr 2023

Researchers identify a type of immune cell that drives chronic organ transplant failure

University of Pittsburgh researchers have identified a type of immune cell that drives chronic organ transplant failure in a mouse model of kidney transplantation and uncovered pathways that could be therapeutically targeted to improve patient outcomes.

21 Apr 2023

Is there an association between exposure to ultrafine particles during pregnancy and influenza infection severity?

Researchers explored the impact of exposure to ultrafine particles during pregnancy on the risk of influenza.

19 Apr 2023

Understanding human mycobiome commensalism and pathogenesis

Researchers explored commensalism and pathogenesis relationships in the human mycobiome.

18 Apr 2023

Study reviews the diagnosis and treatment of acute myocarditis

Scientists have recently reviewed and summarized the evidence regarding diagnosing and treating acute myocarditis.

6 Apr 2023

Long-term protection and high efficacy of bivalent BA.1 booster confirmed in older adults

Researchers estimated the duration of protection with monovalent vaccination and the efficacy of bivalent vaccine boosters.

5 Apr 2023

UCSD engineers develop a biodegradable polymer system to treat rheumatoid arthritis

A team led by engineers at the University of California San Diego has developed a biodegradable polymer system to treat rheumatoid arthritis, an autoimmune and inflammatory disease, by working in concert with the power of the human immune system.

4 Apr 2023

Probiotic E. coli secretes proteins of therapeutic value into its surroundings

Humans are colonized with thousands of bacterial strains. Researchers are now focused on genetically modifying such bacteria to enhance their intrinsic therapeutic properties.

31 Mar 2023

Johns Hopkins Medicine surgeons to receive $21.4 million to advance xenotransplantation research

As part of the worldwide effort to facilitate a research and clinical pathway toward successful xenotransplantation -; the transplantation of living cells, tissues and organs from one species to another -; two Johns Hopkins Medicine surgeons, Kazuhiko Yamada, M.D., Ph.D., and Andrew Cameron, M.D., Ph.D., will receive a total of $21.4 million in funding over the next two years under two sponsored research agreements with biotechnology company United Therapeutics Corporation.

29 Mar 2023