Immunosuppression News and Research

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Immunosuppression involves an act that reduces the activation or efficacy of the immune system. Some portions of the immune system itself have immuno-suppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions.

Real-world data on efficacy and safety of COVID vaccines in Canada

In a recent study posted to the medRxiv* preprint server, researchers evaluated the efficacy and safety of the coronavirus disease 2019 (COVID-19) vaccines in young and elderly cohorts from Canada.

14 Feb 2022

Next era of transplantation is on the horizon, transplant chief says

Satish Nadig, MD, PhD, the Edward G. Elcock Professor of Surgical Research and director of the Comprehensive Transplant Center (CTC), said he arrived at Feinberg in November 2021 with a mission statement: "to have patient-centric impact through quality innovation and education."

8 Feb 2022

Safety and immunogenicity of high-dose quadrivalent influenza vaccine and mRNA-1273 vaccine booster in older adults

A new study has determined the safety and immunogenicity after concomitant administration of QIV-HD and a third dose of the mRNA-1273 vaccine among older adults in the USA

2 Feb 2022

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

The authors highlight that they have created a quantitative framework that allows the dynamic mechanism of the immune response to SARS-CoV-2 to be properly investigated.

2 Feb 2022

Response to COVID-19 vaccine booster in seronegative kidney transplant recipients

Modification of vaccination strategies is needed to improve the immune response to SARS-CoV-2 vaccination in kidney transplant recipients (KTRs).

31 Jan 2022

Combined strategy suppresses the growth of deadly brain tumor

Short bursts of radiation therapy dramatically enhanced the efficiency of targeting glioblastomas with natural nanoparticle-based immunotherapy, thus suppressing growth of the deadly tumor, inducing anti-tumor immunity and prolonging survival in animal models, a research team at Massachusetts General Hospital has discovered.

31 Jan 2022

Study assesses the antibody response to additional dose of COVID-19 vaccine in transplant recipients

A study has begun to assess the antibody response to an additional dose of a COVID-19 mRNA vaccine in kidney and liver transplant recipients, either alone or with a concurrent reduction in immunosuppressive medication.

31 Jan 2022

Study explores factors associated with COVID-19 vaccine hesitancy in individuals with psoriasis

About 40% of people living with psoriasis have had delays to psoriasis treatment and care from the COVID-19 pandemic, according to a new study posted to the medRxiv* server. People of younger age and belonging to an ethnic minority group were more likely to be affected by these disruptions to care.

30 Jan 2022

Blood proteoforms may help predict liver transplant rejection

Northwestern University scientists have discovered families of proteins in the body that could potentially predict which patients may reject a new organ transplant, helping inform decisions about care.

27 Jan 2022

Antibodies against SARS-CoV-2 found to persist for up to 15 months after infection

In a new study, a team of researchers explored the association between total immunoglobulin (IgM, IgA, and IgG) against SARS-CoV-2 and protective immunity.

26 Jan 2022

Novel SARS-CoV-2 mutations reported in chronic HIV patients

A new study describes the emergence of new SARS-CoV-2 variants in three immunocompromised patients.

23 Jan 2022

UAB research outlines successful xenotransplantation of genetically modified kidneys

The University of Alabama at Birmingham Marnix E. Heersink School of Medicine announces today the first peer-reviewed research outlining the successful transplant of genetically modified, clinical-grade pig kidneys into a brain-dead human individual, replacing the recipient's native kidneys.

20 Jan 2022

Subcutaneous nanotherapy can make immunomodulation more effective in people with type 1 diabetes

Individuals living with type 1 diabetes must carefully follow prescribed insulin regimens every day, receiving injections of the hormone via syringe, insulin pump or some other device. And without viable long-term treatments, this course of treatment is a lifelong sentence.

18 Jan 2022

New method may help make immunomodulation more effective in individuals with Type 1 diabetes

Individuals living with Type 1 diabetes must carefully follow prescribed insulin regimens every day, receiving injections of the hormone via syringe, insulin pump or some other device. And without viable long-term treatments, this course of treatment is a lifelong sentence.

17 Jan 2022

Efficacy and safety of mRNA-based SARS-CoV-2 vaccination in immuno-compromised subjects

A team of researchers assessed the immune response after administering a SARS-COV-2 vaccine in immuno-compromised subjects who are potentially at an increased risk to experience severe COVID-19 and inadequate response to SARS-CoV2 vaccination.

17 Jan 2022

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

In a new study, a team of researchers investigated the impact of the fourth dose of a vaccine against COVID-19 in kidney transplant recipients, who had not mounted a humoral immune response to three doses of vaccine.

11 Jan 2022

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

A new study found that a booster dose vaccination against COVID-19 was successful in taking binding. and neutralizing antibodies to levels higher than those observed after the initial double-dose regimen.

7 Jan 2022

Transplant recipients benefit from a COVID-19 vaccine booster

A new preprint research paper posted to the medRxiv* server describes the reduction in humoral immunity in SOTR following vaccination, as well as the improvement with an additional dose of the vaccine.

4 Jan 2022

BNT162b2 provides low vaccine responders adequate anti-spike and neutralizing antibodies to prevent SARS-CoV-2

A new study, published on the medRxiv* preprint server, investigated the changes in SARS-CoV-2 antibody levels among HCWs after SARS-CoV-2 vaccination. The study also assessed whether low responders produced sufficient SARS-CoV-2 anti-spike and neutralizing antibodies.

4 Jan 2022

Factors associated with SARS-CoV-2 breakthrough infection in fully vaccinated individuals

New study findings showed that the SARS-CoV-2 breakthrough infections are rare and show mild or asymptomatic profiles generally. The breakthrough infection occurs early after vaccination in almost 50% of the cases within 70 to 80 days post full vaccination.

30 Dec 2021

Immunosuppression News and Research

Further Reading

Real-world data on efficacy and safety of COVID vaccines in Canada

Next era of transplantation is on the horizon, transplant chief says

Safety and immunogenicity of high-dose quadrivalent influenza vaccine and mRNA-1273 vaccine booster in older adults

Quantitative framework to investigate the dynamic mechanism of host immune response confronting SARS-CoV-2 infection

Response to COVID-19 vaccine booster in seronegative kidney transplant recipients

Combined strategy suppresses the growth of deadly brain tumor

Study assesses the antibody response to additional dose of COVID-19 vaccine in transplant recipients

Study explores factors associated with COVID-19 vaccine hesitancy in individuals with psoriasis

Blood proteoforms may help predict liver transplant rejection

Antibodies against SARS-CoV-2 found to persist for up to 15 months after infection

Novel SARS-CoV-2 mutations reported in chronic HIV patients

UAB research outlines successful xenotransplantation of genetically modified kidneys

Subcutaneous nanotherapy can make immunomodulation more effective in people with type 1 diabetes

New method may help make immunomodulation more effective in individuals with Type 1 diabetes

Efficacy and safety of mRNA-based SARS-CoV-2 vaccination in immuno-compromised subjects

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

Transplant recipients benefit from a COVID-19 vaccine booster

BNT162b2 provides low vaccine responders adequate anti-spike and neutralizing antibodies to prevent SARS-CoV-2

Factors associated with SARS-CoV-2 breakthrough infection in fully vaccinated individuals

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

Top-Down Proteomics: Bridging the Genotype-to-Phenotype Gap

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