Infectious Diseases News and Research

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PolyMedix receives clearance to initiate phase I clinical study of novel systemic antibiotic compound

PolyMedix, Inc. has received a notice of no objection from Health Canada for the Company's Clinical Trial Application ("CTA") for its defensin mimetic antibiotic compound, PMX-30063. This notice of no objection allows for the initiation of human clinical studies in Canada. PMX-30063 is the first defensin mimetic antibiotic compound cleared to enter human clinical trials for systemic use, representing an entirely new class of antibiotic drugs.

9 May 2008

Taking the sex out of sexual health screening

Young women would accept age-based screening for the sexually transmitted infection chlamydia, but would want this test to be offered to everyone, rather than to people 'singled out' according to their sexual history.

9 May 2008

Rapid HIV tests highly effective in preventing mother-to-child HIV transmission in India

Rapid HIV tests have been found to be highly effective in preventing mother-to-child HIV transmission in clinical trials in India, according to a study published online Tuesday in PLoS Medicine, the Times of India reports (Sinha, Times of India, 5/7). For the study, the researchers used OraSure Technologies' OraQuick Advance Rapid HIV 1/2 Antibody Test (Derfel, Montreal Gazette, 5/6

8 May 2008

Role of genetic components of dendritic cells could lead to more effective drugs

For the first time, researchers from the University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction. Targeting these elements could result in more effective drugs to treat allergic disorders and asthma, according to a study reported in the May edition of the journal Nature Medicine.

7 May 2008

GenVec announces grant for respiratory syncytial virus vaccine program

GenVec, Inc. announced today that it has received an Advanced Technology Phase I Small Business Innovation and Research (SBIR) grant from the National Institute of Allergy and Infectious Diseases, of the National Institutes of Health, to support the Company's efforts to develop vaccines for the prevention of respiratory syncytial virus (RSV).

7 May 2008

Researchers highlight distinct subtypes of myalgic encephalomyelitis

Researchers have identified distinct subtypes of myalgic encephalomyelitis (ME/CFS - also referred to as chronic fatigue syndrome) and there is renewed hope that treatments are available for this debilitating neurological illness.

7 May 2008

Corticosteroids provide no survival benefit for children with bacterial meningitis

Corticosteroids given to children who are hospitalized for bacterial meningitis do not provide a benefit in survival or in reduced hospital stays, according to a large multicenter study by pediatric researchers. This finding stands in contrast to previous studies in hospitalized adults, for which corticosteroids dramatically reduced mortality.

6 May 2008

New discovery on role of vital protein that fights meningitus

A University of Leicester researcher has discovered how a protein in the blood - linked to defence against meningitis - plays a more vital role than previously understood in the body's immune defence system.

6 May 2008

Relief in sight for arthritis triggered by viral infections such as Ross River fever

Australian scientists believe they may have discovered the possibility of relief for those suffering with the debilitating arthritis triggered by viral infections such as Ross River fever.

6 May 2008

New saliva-based HIV test gives results in 20 minutes!

The usual waiting period for the results of a HIV test can seem like an eternity, especially in emergency situations where results are needed immediately. Also it requires a blood sample, which is invasive and often painful. Recognizing the urgent need for a faster and less invasive diagnostic method, Dr. Nitika Pant Pai, from Marina Klein's research team at the MUHC has just finished testing a new saliva-based test that gives results in approximately 20 minutes! She describes her findings in an article that will appear in the May 6th, 2008 issue of PLoS Medicine.

6 May 2008

Enterovirus 71 in China claims the lives of two more children

The World Health Organisation (WHO) has warned that a virus that has killed 24 young children and infected more than 5,000 could continue to spread regardless of efforts to contain it.

5 May 2008

Cholera study provides exciting new way of looking at infectious disease

Scientists in Italy have discovered a new perspective in the study of infectious disease. Normally, such studies are based upon laboratory work looking at an organism and how it works within the human body.

2 May 2008

Novavax opens new U.S. vaccine plant in Rockville, Maryland

Officials from Novavax, Inc., the State of Maryland and Montgomery County today celebrated the opening of Novavax's new state-of-the-art vaccine production facility at the company's headquarters in Rockville, Maryland.

1 May 2008

3M Drug Delivery System collaborates on vaccine adjuvants

3M Drug Delivery Systems announces the signing of a non-exclusive license agreement with the Infectious Disease Research Institute (IDRI) in support of vaccine research for humanitarian efforts in developing countries. Under the agreement, 3M will donate its patented toll-like receptor (TLR) immune response modifier compounds.

1 May 2008

Chinese authorities again accused of concealing outbreak of deadly virus

As the number of people in China affected by a deadly intestinal virus continues to rise, Chinese authorities have been accused of trying conceal the outbreak

1 May 2008

Young children hospitalized for flu associated with higher costs and higher risk illness

The high costs of hospitalizing young children for influenza creates a significant economic burden in the United States, underscoring the importance of preventive flu shots for children and the people with whom they have regular contact, according to research led by Cincinnati Children's Hospital Medical Center and presented May 4 at the Pediatric Academic Society annual meeting in Honolulu, Hawaii.

30 Apr 2008

ImmunoVaccine Technologies patents DepoVax vaccine platform

ImmunoVaccine Technologies Inc. (IVT), a vaccine development company, unveiled today its DepoVax platform, a novel depot vaccine delivery system used to increase the efficacy and strength of vaccines. IVT has filed additional patents to protect the DepoVax concept.

30 Apr 2008

AstraZeneca submits sNDA for SYMBICORT in chronic obstructive pulmonary disease

AstraZeneca today announced that it submitted a supplemental New Drug Application (sNDA) to the U.S. Food and Drug Administration (FDA) for approval of a new indication for SYMBICORT (budesonide/formoterol fumarate dihydrate) Inhalation Aerosol for the treatment of patients with Chronic Obstructive Pulmonary Disease (COPD). SYMBICORT is currently approved for the long-term maintenance treatment of asthma in patients 12 years and older.

30 Apr 2008

Discovery of quick method for making human monoclonal antibodies against flu

Human monoclonal antibodies (mAbs) - highly specific, identical, infection-fighting proteins produced in large quantities in the lab in cell lines that are derived from a single antibody-producing cell - against influenza can be rapidly produced in the lab, according to a new report from scientists supported by the National Institutes of Health (NIH).

30 Apr 2008

Scientists determine drug target for the most potent botulinum neurotoxin

Botulinum neurotoxin - responsible for the deadly food poisoning disease botulism and for the beneficial effects of smoothing out facial wrinkles - can also be used as a dreaded biological weapon. When ingested or inhaled, less than a billionth of an ounce can cause muscle paralysis and eventual death. Although experimental vaccines administered prior to exposure can inhibit the destructive action of this neurotoxin - the most deadly protein known to humans - no effective pharmacological treatment exists.

29 Apr 2008