Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Fructose overload

Here's one tip for how to eat at the holidays: Don't take your cues from Santa. The sugary cookies and fat-laden fruitcakes the mythical North Pole resident eats are a no-no.

13 Dec 2007

Smoking and type 2 diabetes

A review of previous studies indicates that people who currently smoke have an increased risk of developing type 2 diabetes, compared with non-smokers, according to an article in the December 12 issue of JAMA.

13 Dec 2007

Sugary drinks may increase Alzheimer's risk

Excess drinking of sugary beverages like soda may increase the risk of Alzheimer's disease, suggests new research in mice.

10 Dec 2007

Not enough sleep raises the risk for diabetes

The most common factors believed to contribute to diabetes are a decreased amount of physical activity and access to highly palatable processed foods.

3 Dec 2007

Sirtris Pharmaceuticals unveils promising, novel SIRT1 activators for treating diseases of aging

Sirtris Pharmaceuticals has announced that findings in the journal Nature demonstrate that Sirtris has developed novel drug candidates that offer a promising, new approach to treating diseases of aging, including Type 2 Diabetes, by targeting SIRT1, a gene that controls the aging process.

29 Nov 2007

Brain may have important influences on glucose metabolism and insulin action

An appetite-suppressing chemical also improves glucose tolerance and lowers insulin levels in obese and diabetic mice, researchers report in the November issue of Cell Metabolism, a publication of Cell Press.

13 Nov 2007

Brain appears to play important role in glucose metabolism and insulin action

6 Nov 2007

Inflammation causes insulin resistance not obesity

Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that inflammation provoked by immune cells called macrophages leads to insulin resistance and Type 2 diabetes.

6 Nov 2007

Fat cells release a protein that aids insulin secretion from pancreatic beta cells

The body's fat cells help the pancreas do its job of secreting insulin, according to research at Washington University School of Medicine in St. Louis.

6 Nov 2007

Increased glucose level is a strong risk factor for colorectal cancer

Diabetes is a very common illness that affects more than 20 million people in the U.S. and it is estimated an additional 54 million Americans have pre-diabetes, a condition that occurs when a person's blood glucose levels are higher than normal but not high enough for a diagnosis of type 2 diabetes.

2 Nov 2007

High-fat diet makes mice susceptible to liver injury

A high fat diet may kill regulatory T cells in the liver, allowing steatosis (simple fatty liver) to develop into steatohepatitis (fatty liver with inflammation), according to the results of a new study in the November issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD).

2 Nov 2007

Research identifies two genes that may play a role in insulin resistance

New research from UAB (University of Alabama at Birmingham) identifies two genes that may play a role in insulin resistance, opening a new avenue for researchers searching for treatments for type 2 diabetes and metabolic syndrome.

28 Oct 2007

Exercise improves thinking and reduces diabetes in overweight kids

Just three months of daily, vigorous physical activity in overweight children improves their thinking and reduces their diabetes risk, researchers say.

22 Oct 2007

Low doses of a red wine ingredient resveratrol fights diabetes in mice

A chemical found in the skins of red grapes and in red wine can improve the sensitivity of mice to the hormone insulin, according to a report in the October issue of Cell Metabolism, a Cell Press publication.

3 Oct 2007

Leptin plays a major role in islet cell growth and insulin secretion

A new Joslin-led study has shown that leptin, a hormone known mainly for regulating appetite control and energy metabolism, plays a major role in islet cell growth and insulin secretion.

2 Oct 2007

Ostructive sleep apnea and continuous positive airway pressure

Researchers in Brazil have found that treating patients who suffer from obstructive sleep apnea (OSA) with continuous positive airway pressure (CPAP) dramatically reduces early indications of atherosclerosis in just months, linking OSA directly to the hardening or narrowing of the arteries.

29 Sep 2007

Discovery supports theory of Alzheimer's disease as form of diabetes

Insulin, it turns out, may be as important for the mind as it is for the body.

27 Sep 2007

ACTOS associated with reduced risk of heart attack and stroke in patients with type 2 diabetes

Results presented at the 43rd Annual Meeting of the European Association for the Study of Diabetes demonstrate the ability of ACTOS (pioglitazone HCl) to reduce the risk of ischemic cardiovascular disease in patients with type 2 diabetes.

20 Sep 2007

Metformin could potentially improve pregnancy outcomes in women with insulin resistance

Women who are obese, have type 2 diabetes or a family history of type 2 diabetes could one day have more successful pregnancies because of a study at Washington University School of Medicine in St. Louis.

10 Sep 2007

Insights into the physiological basis of obesity

The past decade has witnessed an explosion of information regarding the role of the central nervous system (CNS) in the development of obesity and the influence of peripheral, hormonal signals that regulate CNS function to regulate food intake and metabolism.

3 Sep 2007