Insulin Resistance News and Research

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Insulin Resistance is a condition in which the body does not respond to insulin properly. This is most common in Type II diabetes or associated with obesity, ketoacidosis, infection, and certain rare conditions. Diminished effectiveness of insulin in lowering blood glucose levels requiring 200 units or more of insulin per day to prevent hyperglycemia or ketosis.

Dundee Diabetes Research Centre in Scotland

In a joint venture between two faculties with a common interest in Diabetes research, a facility, the Dundee Diabetes Research Centre has been launched reinforcing the city's standing as one of the world's key hubs of research into the disease.

21 Apr 2005

Drugs targeted at muscle cells can be of use in the treatment of diabetes patients with insulin resistance

Type 2 diabetes is a clinical disease characterised by disruption to the metabolism of glucose and lipids as well as to the production of and physiological reactions to insulin.

19 Apr 2005

One-meter waistline predicts high risk of diabetes and heart disease

People with a waistline of one meter or more are at serious risk of insulin resistance - an early stage in the development of diabetes and heart disease, finds a study published online by the BMJ.

19 Apr 2005

Rimonabant appears to reduce risk factors for heart disease in obese people

A new drug could substantially reduce the bodyweight, waist circumference, and risk factors for heart disease in obese people, according to results of a randomised trial published in this week’s issue of The Lancet.

19 Apr 2005

Scientists use transcription factors to increase insulin production in diabetic mice

A group of Japanese scientists has used gene therapy to deliver three insulin transcription factors, MafA, PDX-1, and NeuroD, to the livers of diabetic mice. As a result, the mice experienced an increase in insulin gene expression and insulin production, raising the possibility that this could eventually be used to treat diabetes.

13 Apr 2005

New findings about insulin-signaling in the liver could prove useful in understanding type 2 diabetes

A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes.

12 Apr 2005

Polycystic ovary syndrome increases chance of developing cardiovascular disease

Women who suffer from polycystic ovary syndrome (PCOS), one of the most common causes of female infertility in the U.S., have an increased chance of developing cardiovascular disease, according to a new study published this month in The Journal of Clinical Endocrinology & Metabolism, published by The Endocrine Society.

6 Apr 2005

Alteration of steroid receptor genes creates fat burning muscle

The Salk Institute scientist who earlier discovered that enhancing the function of a single protein produced a mouse with an innate resistance to weight gain and the ability to run a mile without stopping has found new evidence that this protein and a related protein play central roles in the body's complex journey to obesity and offer a new and specific metabolic approach to the treatment of obesity related disease such as Syndrome X (insulin resistance, hyperlipidemia and atherosclerosis).

4 Apr 2005

New trial for treatment of liver disease

The Nonalcoholic Steatohepatitis (NASH) Clinical Research Network is launching its first two clinical trials for the study of NASH, a liver disease that resembles alcoholic liver disease but occurs in patients who drink little or no alcohol.

3 Apr 2005

Pediatric burn victims’ recovery, diabetes aided by Fenofibrate

One of the immediate serious results of sudden extreme trauma or stress, including burns and even surgery, is insulin resistance, or diabetes. As a result, healing is delayed, especially in the case of severe burns, and since the body is unable to fully use blood sugar for energy, muscle tissue is broken down as the body scavenges for other possible energy sources.

3 Apr 2005

Important link between kidney damage and cardiac problems

Scientists have identified an important link between kidney damage and cardiac problems, creating new possibilities for treating the primary cause of death in kidney disease patients.

29 Mar 2005

Variation in the gene ENPP1 may predict risk for diabetes

A particular gene variant that could serve as a predictor for type 2 diabetes has been identified by researchers at UT Southwestern Medical Center.

28 Mar 2005

Questions about validity of HOPE TOO vitamin E study

A study published in the March 16 issue of Journal of the American Medical Association (JAMA) suggesting that a "daily-dose" of vitamin E (400 international units) among high-risk (chronically ill) cardiovascular patient populations is associated with a greater risk of heart failure is being challenged by leading health researchers around the country who claim the study lacks the adequate research and controlled sampling audience to justify this conclusion.

16 Mar 2005

Q. What turns an obese person into a person with diabetes? - A. Leptin

Twin epidemics of obesity and type 2 diabetes are bearing down on the world's population, threatening the lives of hundreds of millions of people. But scientists are still trying to determine how the two conditions are linked, and what it takes to turn an obese person into a person with diabetes.

16 Mar 2005

Diabetes Busting Burgers!

Chemists with the U.S. Department of Agriculture recently presented a preliminary report to the 229th national meeting of the American Chemical Society, in which they say they have discovered a form of soluble cellulose that, if added to high-fat food. The new finding could soon benefit people who regularly eat fast-foods that are high in fat.

16 Mar 2005

Obesity among African-American stroke survivors increases risk factors for recurrent stroke

Obesity may put African-Americans who have survived one stroke at risk for a second stroke by increasing their risk of hypertension (high blood pressure), diabetes and high cholesterol, according to an article in the March issue of Archives of Neurology, one of the JAMA/Archives journals.

14 Mar 2005

A weighty issue: can your eating habits make you infertile?

The societal pressures on women to be attractive, successful, and thin are stronger than ever. The desirable woman portrayed in the media is much thinner than the average woman. Popular slogans such as "thin is in" and "you can never be too rich or too thin" have equated thinness with happiness. The result is that for the first time in history, being attractive means being thin.

7 Mar 2005

Insulin levels linked to Alzheimer's disease

Insulin and its related proteins are produced in the brain, and according to researchers from Rhode Island Hospital and Brown Medical School, reduced levels of this combination can be linked to Alzheimer's disease. The findings are reported in the March issue of the Journal of Alzheimer's Disease.

7 Mar 2005

Childhood obesity is a serious health problem in Australia

Professor Michael Booth, co-director of the University of Sydney's Centre for Overweight and Obesity, said teenagers were already showing signs of serious illness caused by their weight.

24 Feb 2005

Link between diabetes and obesity

Scientists at Washington University School of Medicine in St. Louis used genetically modified mice to uncover a potentially important link between diabetes and obesity.

15 Feb 2005