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Texas Heart Institute receives $1.14 million grant to develop first-in-class drug to treat cardiovascular disease

The National Heart, Lung, and Blood Institute (NHLBI) recently awarded The Texas Heart Institute (THI) a two-year, $1.14 million grant to develop a novel, first-in-class drug to treat cardiovascular disease (CVD) as a significant improvement to current treatment regimens -; specifically for adverse events arising from atherosclerosis.

22 Aug 2023

Can air pollution shape adolescent brain development? New study reveals sex-specific effects of PM2.5, NO2, and O3 on white matter microstructure

Researchers investigated the sex-stratified effects of childhood exposure to ambient air pollutants.

22 Aug 2023

Scientists uncover new molecular targets for cardiovascular regulation

Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States and a leading research center for diabetes and other life-threatening illnesses, have uncovered new molecular targets on a cell receptor that play a major role in cardiovascular regulation.

14 Aug 2023

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Researchers explored the structural basis of agonist specificity of α1A-adrenergic receptors (α1-ARs).

14 Aug 2023

Synergistic winter flounder antimicrobial peptides unveil new path to enhanced bactericidal therapy

The synergistic action of six winter flounder (WF) antimicrobial peptides (AMPs) against bacterial pathogens.

14 Aug 2023

Newly identified protein plays a key role in the action of emerging anticancer therapies

Scientists have identified a protein that plays a pivotal role in the action of several emerging cancer therapies. The researchers say the discovery will likely aid efforts to fine-tune the use of immunotherapies against several challenging cancers.

31 Jul 2023

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

Neurons are the cells that constitute neural circuits and use chemicals and electricity to receive and send messages that allow the body to do everything, including thinking, sensing, moving, and more.

28 Jul 2023

Study unravels how mitochondria call for help when under stress

Originally, the powerhouses of higher cells, the mitochondria, were independent organisms. Researchers at Goethe University Frankfurt have investigated to what extent their metabolism has blended with that of their host cells in the course of evolution, using the example of a mitochondrial stress response.

28 Jul 2023

Researchers discover a protein that plays critical roles in alerting the body to a bacterial infection

A team led by researchers at Massachusetts General Hospital (MGH) has discovered a protein that plays critical roles in alerting the body to a bacterial infection and initiating an effective immune response to fight back against the invasion.

27 Jul 2023

ARMGO Pharma Enrolls First Patient in Phase 2 Trial of ARM210 for the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia

Trial to investigate the safety and efficacy of ARM210 for the treatment of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT).

21 Jul 2023

Pertussis vaccination responses in COPD patients

Researchers evaluated the humoral and cellular immune responses to pertussis vaccination in COPD patients.

21 Jul 2023

Using single-cell mass spectrometry to study antimicrobial treatment failure

Laura-Isobel McCall, Ph.D., and Zhibo Yang, Ph.D., co-principal investigators and associate professors of chemistry and biochemistry in the Dodge Family College of Arts and Sciences at the University of Oklahoma, have been awarded a prestigious R01 grant from the National Institutes of Health for their project, "Novel single-cell mass spectrometry to assess the role of intracellular drug concentration and metabolism in antimicrobial treatment failure."

19 Jul 2023

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Researchers used a murine model to demonstrate that functional excision of murine PITPNA eventually led to hyperglycemia in mice.

19 Jul 2023

Novel approach: intranasal vaccination strategy targets Omicron COVID-19 variants

Researchers tested the efficacy of a two to three-dose intranasal (IN) regimen of the NDV-HXP-S vaccine.

14 Jul 2023

Plant cell study reveals new role for enzyme in lipid metabolism

A new study by Rice University bioscientists explains how basic cellular structures common to most life forms collaborate to fuel growth in a model plant organism. The findings could shed light on corresponding mechanisms in human cells.

12 Jul 2023

Light-powered technology could guide immune cells to infections and cancer

The immune system's ability to send its army of immune cells to the right location with the right level of response is key to the body's ability to fight an infection or a growing tumor.

12 Jul 2023

Biomimetic nanocarriers fuse with cell membranes to deliver drugs

In drug delivery, the therapeutic behavior of the nanocarriers is limited by the "foreign" character of their surface.

12 Jul 2023

New insights into how dendritic cells arm T cells to fight disease

As part of the immune system, dendritic cells are essential for fighting body cells that have degenerated or are infected with a virus.

11 Jul 2023

Study provides insights into the molecular mechanism of Batten disease

Neuronal Ceroid Lipofuscinosis are a group of devastating neurodegenerative lysosomal storage disorders that begin in childhood. Mutations in CLN3 gene lead to a NCL called Batten disease, characterized by the progressive loss of vision, movement, and cognition.

6 Jul 2023

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Researchers present the mechanisms by which SARS-CoV-2 could infect the brain and affect memory.

5 Jul 2023

Intracellular News and Research

Texas Heart Institute receives $1.14 million grant to develop first-in-class drug to treat cardiovascular disease

Can air pollution shape adolescent brain development? New study reveals sex-specific effects of PM2.5, NO2, and O3 on white matter microstructure

Scientists uncover new molecular targets for cardiovascular regulation

Unveiling α1-AR secrets: breakthrough structures and targeted drug design

Synergistic winter flounder antimicrobial peptides unveil new path to enhanced bactericidal therapy

Newly identified protein plays a key role in the action of emerging anticancer therapies

Golgi apparatus may play a role in neuronal circuit reorganization during postnatal brain development

Study unravels how mitochondria call for help when under stress

Researchers discover a protein that plays critical roles in alerting the body to a bacterial infection

ARMGO Pharma Enrolls First Patient in Phase 2 Trial of ARM210 for the Treatment of Catecholaminergic Polymorphic Ventricular Tachycardia

Pertussis vaccination responses in COPD patients

Using single-cell mass spectrometry to study antimicrobial treatment failure

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Novel approach: intranasal vaccination strategy targets Omicron COVID-19 variants

Plant cell study reveals new role for enzyme in lipid metabolism

Light-powered technology could guide immune cells to infections and cancer

Biomimetic nanocarriers fuse with cell membranes to deliver drugs

New insights into how dendritic cells arm T cells to fight disease

Study provides insights into the molecular mechanism of Batten disease

Beyond the lungs: SARS-CoV-2's multi-organ impact revealed

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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