Intracellular News and Research

RSS

Researchers discover two mutations responsible for neurological condition

Mayo Clinic researchers have discovered two mutations responsible for a devastating neurological condition they first identified 15 years ago. The researchers say their study -- appearing in Nature Genetics -- has revealed a new neural pathway that may help understand a variety of similar conditions.

2 May 2011

Signaling pathway reveals mechanism for B cell differentiation in immune response

An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology (RCAI) has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells. The finding establishes a role for the extracellular signal-regulated kinase (ERK) signaling pathway in B cell differentiation, a key step toward the development of B cell-targeted drugs for treatment of autoimmune diseases and allergies.

25 Apr 2011

Molecular Templates to present preclinical data of ETB platform technology at 5th RNAi and miRNA World Congress

Molecular Templates, Inc., a biopharmaceutical company focused on the discovery and development of a new class of small biologic therapies called Engineered Toxin Bodies (ETB), announced today that it will present preclinical data in a poster presentation at the 5th Annual RNAi and miRNA World Congress in Boston, MA during April 26-27, 2011.

22 Apr 2011

Valuable insight into immune response

An article in Science Signaling by researchers at the RIKEN Research Center for Allergy and Immunology has clarified for the first time the mechanism governing differentiation of B cells into antibody-producing plasma cells.

22 Apr 2011

LMP1 viral protein needs TRAF6 cellular protein to promote B cell activation signaling pathways: Study

By identifying a surprising association of two intracellular proteins, University of Iowa researchers have laid the groundwork for the development of new therapies to treat B cell lymphomas and autoimmune disease.

20 Apr 2011

NIAID finding to accelerate Chlamydia infection study

WHAT: In a new study from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, scientists describe successfully mutating specific genes of Chlamydia bacteria, which cause the most common sexually transmitted infection in the United States as well as a type of blindness common in developing nations.

12 Apr 2011

Ubiquitine D gene may be linked to celiac disease

Celiac disease (CD) involves intolerance to gluten and, consequently, suffering chronic illness in the small intestine. It is a genetic disorder, the immunological indications of which can be traced in the human body prior to the everyday activities of future sufferers being affected. For example, persons with genetic antecedents for CD develop antibodies against the gene tTG (the enzyme known as tissue transglutaminase), even before the illness becomes active, due to a cell reaction against gluten.

5 Apr 2011

OncoGenex presents OGX-427 preclinical data in prostrate cancer at AACR meeting

OncoGenex Pharmaceuticals, Inc. announced today that preclinical data utilizing their pipeline compound OGX-427 was presented at the AACR 102nd Annual Meeting 2011.

5 Apr 2011

Study suggests causal link between HSV1 and Alzheimer's disease

Laboratories at the University of New Mexico (UNM), Brown University, and House Ear Institute (HEI) have developed a new technique to observe herpes simplex virus type 1 (HSV1) infections growing inside cells. HSV1, the cause of the common cold sore, persists in a latent form inside nerve cells.

5 Apr 2011

Blocking TNF-related apoptosis-inducing ligand pathway partially reconstitutes HBV-specific T cells

A new study presented today at the International Liver Congress shows a novel pathway where activated natural killer (NK) cells expressing death ligands may excessively down-modulate the antiviral immune response in chronic HBV patients.

2 Apr 2011

Anavex screening volunteers for phase I, first-in-human clinical study in Alzheimer’s

Anavex Life Sciences Corp. today announced screening of the first healthy volunteers for the Phase I clinical study of ANAVEX 2-73, its lead compound for the treatment of Alzheimer’s disease. ANAVEX 2-73 is the first of a new class of wholly-owned, oral, disease-modifying compounds, which act through sigma-1 receptor agonist as well as muscarinic cholinergic effects and up-regulation of Bcl-2.

31 Mar 2011

Researchers characterize novel form of ubiquitin regulatory protein

Researchers at the Proteome Center Tuebingen characterize a novel form of the regulatory protein ubiquitin, involved in inflammation and cell death.

31 Mar 2011

Towards accurate simulation of whole working cells

Researchers have built a computer model of the crowded interior of a bacterial cell that - in a test of its response to sugar in its environment - accurately simulates the behavior of living cells.

31 Mar 2011

Molecular Templates ETB preclinical data against cancer to be presented at AACR meeting

Molecular Templates, Inc., a biopharmaceutical company focused on the discovery and development of a new class of small biologic therapies called Engineered Toxin Bodies, announced today that it will present preclinical data in two poster presentations at the 102nd American Association for Cancer Research annual meeting in Orlando, FL during April 2-6, 2011.

31 Mar 2011

FDA approves ipilimumab to treat metastatic melanoma

The US Food and Drug Administration announced today that the drug ipilimumab has been approved for the treatment of patients with metastatic melanoma. It is the first drug ever shown to improve overall survival for patients with advanced melanoma.

28 Mar 2011

Smoking during pregnancy increases risk of children becoming smokers too

New research has revealed that prenatal exposure to nicotine increases the vulnerability to nicotine self-administration in adolescent mice. The results support the hypothesis that adolescents with prenatal nicotine exposure are more likely to start smoking earlier than their peers and that they are also more susceptible to the addictive effects of nicotine, especially as a result of stress and peer pressure.

21 Mar 2011

Scientists discover enzyme family that plays a crucial role in regulating cell motility

Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered that members of an enzyme family found in humans and throughout the plant and animal kingdoms play a crucial role in regulating cell motility. Their findings suggest an entirely new strategy for treating conditions ranging from diabetic ulcers to metastatic cancer.

19 Mar 2011

Anavex to commence phase I clinical trial in Alzheimer’s disease

Anavex Life Sciences Corp. (“Anavex”) (OTCBB: AVXL) has announced that its clinical trial application (CTA) for ANAVEX 2-73, the company’s lead compound for Alzheimer’s disease, has been approved by the German regulatory health authority, BfArM. The Phase I trial of ANAVEX 2-73, which includes testing in healthy human volunteers, will commence immediately. In this Phase I program Anavex will assess the safety, maximally tolerated dose, pharmacokinetics and pharmacodynamics of ANAVEX 2-73.

15 Mar 2011

Bonding with mom develops over first few weeks of life in rodent pups

For rodent pups, bonding with mom isn't hard-wired in the womb. It develops over the first few weeks of life, which is achieved by their maturing sense of smell, possibly allowing these mammals a survival advantage by learning to identify mother, siblings, and home.

14 Mar 2011

New discovery: GPCR family of proteins can recognize and respond to wide array of signals

Scientists from The Scripps Research Institute have determined a new structure from a medically important superfamily of proteins. The structure should help instruct the design of a new kind of therapeutics for conditions ranging from Parkinson's disease to inflammation.

11 Mar 2011

Intracellular News and Research

Researchers discover two mutations responsible for neurological condition

Signaling pathway reveals mechanism for B cell differentiation in immune response

Molecular Templates to present preclinical data of ETB platform technology at 5th RNAi and miRNA World Congress

Valuable insight into immune response

LMP1 viral protein needs TRAF6 cellular protein to promote B cell activation signaling pathways: Study

NIAID finding to accelerate Chlamydia infection study

Ubiquitine D gene may be linked to celiac disease

OncoGenex presents OGX-427 preclinical data in prostrate cancer at AACR meeting

Study suggests causal link between HSV1 and Alzheimer's disease

Blocking TNF-related apoptosis-inducing ligand pathway partially reconstitutes HBV-specific T cells

Anavex screening volunteers for phase I, first-in-human clinical study in Alzheimer’s

Researchers characterize novel form of ubiquitin regulatory protein

Towards accurate simulation of whole working cells

Molecular Templates ETB preclinical data against cancer to be presented at AACR meeting

FDA approves ipilimumab to treat metastatic melanoma

Smoking during pregnancy increases risk of children becoming smokers too

Scientists discover enzyme family that plays a crucial role in regulating cell motility

Anavex to commence phase I clinical trial in Alzheimer’s disease

Bonding with mom develops over first few weeks of life in rodent pups

New discovery: GPCR family of proteins can recognize and respond to wide array of signals

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News