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NYU Langone Health performs second successful investigational xenotransplantation procedure

Less than two months after the first breakthrough surgery, NYU Langone Health has performed its second successful investigational xenotransplantation procedure using a genetically engineered pig kidney.

13 Dec 2021

A promising new therapeutic target for kidney disease

Despite nearly two million people dying of acute kidney injury every year, and tens of millions more needing treatment, no effective drug treatment for the condition is available.

7 Dec 2021

Review highlights oncolytic viruses with remarkable ability to destroy cancer cells

With the world still in the grip of a devastating pandemic, it's hard to imagine viruses as something other than hostile enemies to be vanquished.

30 Nov 2021

Study uncovers new mechanism to explain how obesity jeopardizes the functions of skeletal muscle

A decline in metabolism and endurance of skeletal muscle is commonly observed in obese patients, but the underlying mechanism is not well-understood.

30 Nov 2021

Treatment with antihistamines associated with improved responses to immunotherapy

New research from The University of Texas MD Anderson Cancer Center found that treatment with antihistamines, a commonly used allergy medication, was associated with improved responses to immune checkpoint inhibitors.

24 Nov 2021

The antiviral function of BET protein against SARS-CoV-2 infection

Considering the past shreds of evidence on BRD2 and BRD4 associated with viral infections, researchers have recently evaluated the function of all relevant BET proteins during COVID-19 infection.

17 Nov 2021

Study highlights the need for caution while using CRISPR-based gene therapies

A comprehensive study-;conducted by researchers at Sanford Burnham Prebys, the National Cancer Institute (NCI) and other groups-;has shown that gene editing, specifically gene knockout (KO), with CRISPR -Cas9 can favor cells with mutated forms of genes linked to cancer.

11 Nov 2021

Study highlights the critical role of junk DNA in mammalian development

Nearly half of our DNA has been written off as junk, the discards of evolution: sidelined or broken genes, viruses that got stuck in our genome and were dismembered or silenced, none of it relevant to the human organism or human evolution.

19 Oct 2021

Devastating genetic disease in children may be treatable in adulthood

A devastating genetic disease called CDKL5 deficiency disorder (CDD), which strikes in early childhood, may be significantly treatable even in adulthood, a new study from the Perelman School of Medicine at the University of Pennsylvania suggests.

15 Oct 2021

Researchers identify mechanism that can lead to deafness in rare Norrie disease

A team of Mass Eye and Ear Scientists led by Albert Edge, PhD, working with research fellow Yushi Hayashi, MD, PhD, has identified the mechanism that can lead to deafness in the rare syndrome, Norrie disease.

5 Oct 2021

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Corneal defects often heal themselves, but serious injuries that are left untreated can result in inflammation, infection, ulceration and even blindness.

30 Sep 2021

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

New findings identify CASP4/11 as detrimental to inflammation and coagulopathy associated with SARS-CoV-2 infection.

28 Sep 2021

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system.

21 Sep 2021

Researchers employ microbes for storing and retrieving energy from renewable sources

Cornell University bioengineer Buz Barstow is trying to solve a big problem: How to build a low-cost, environmentally friendly and large-scale system for storing and retrieving energy from renewable sources such as wind and solar. Currently, there are no sustainable methods for storing green energy, as batteries are environmentally toxic.

1 Sep 2021

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Aging-US published "The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence" which reported that cellular senescence may be a side effect of chemotherapy and other anti-cancer treatments that may promote inflammation and paracrine secondary senescence in healthy tissues.

31 Aug 2021

Knockout News and Research

NYU Langone Health performs second successful investigational xenotransplantation procedure

A promising new therapeutic target for kidney disease

Review highlights oncolytic viruses with remarkable ability to destroy cancer cells

Study uncovers new mechanism to explain how obesity jeopardizes the functions of skeletal muscle

Treatment with antihistamines associated with improved responses to immunotherapy

The antiviral function of BET protein against SARS-CoV-2 infection

Study highlights the need for caution while using CRISPR-based gene therapies

Study highlights the critical role of junk DNA in mammalian development

Devastating genetic disease in children may be treatable in adulthood

Researchers identify mechanism that can lead to deafness in rare Norrie disease

Aquaporin 5 induction may be a potential therapy to accelerate resurfacing of corneal defects

Caspase-11 identified as regulator of inflammatory pathology in SARS-CoV-2 infections

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

Researchers employ microbes for storing and retrieving energy from renewable sources

DNMT2/TRDMT1 gene knockout may potentiate adverse effects related to drug-induced senescence

Researchers identify potential new treatment for osteoarthritis

Researchers discover molecule that plays an important role in sperm motility regulation

Study: PirB inhibits the self-renewal and differentiation capacities of neural stem cells

Fruit fly provides insight into controlling carbs and fat

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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