Lewy Bodies News and Research

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Novel antisense therapy targets α-synuclein pathologies in neurodegenerative diseases

TMDU researchers demonstrate proof of concept of antisense nucleic acid therapy to prevent the spread of α-synuclein pathologies in synucleinopathies.

25 Jul 2024

New preclinical model offers a unique platform for studying Parkinson's disease process

A new preclinical model offers a unique platform for studying the Parkinson's disease process and suggests a relatively easy method for detecting the disease in people, according to a new study led by Weill Cornell Medicine researchers.

23 Jul 2024

MRI connectome predicts gray matter atrophy progression in early Parkinson's disease

The structural and functional organization of the brain as shown on MRI can predict the progression of brain atrophy in patients with early-stage, mild Parkinson's disease, according to a study published today in Radiology, a journal of the Radiological Society of North America (RSNA).

25 Jun 2024

Enlarged prostate medications may also decrease the risk for dementia with Lewy bodies

A new study suggests that certain drugs commonly used to treat enlarged prostate may also decrease the risk for dementia with Lewy bodies (DLB).

19 Jun 2024

AI-driven blood test offers hope for early Parkinson's diagnosis

A team of researchers, led by scientists at UCL and University Medical Center Goettingen, Germany, have developed a simple blood test that uses artificial intelligence (AI) to predict Parkinson's up to seven years before the onset of symptoms.

19 Jun 2024

AI techniques massively accelerate the search for Parkinson's disease treatments

Researchers have used artificial intelligence techniques to massively accelerate the search for Parkinson's disease treatments.

17 Apr 2024

Study reveals molecular changes in brain cells with Lewy bodies

A new study from Van Andel Institute scientists offers a first look into the complex molecular changes that occur in brain cells with Lewy bodies, which are key pathological hallmarks of Parkinson's disease and some dementias.

16 Apr 2024

UCL and Oxford lead major dementia diagnosis trials

Thousands of people in the UK are to take part in countrywide trials to identify accurate and quick blood tests that can diagnose dementia, led by research teams at UCL and Dementias Platform UK, based at the University of Oxford.

4 Apr 2024

New treatments in sight for challenging neuropsychiatric symptoms in neurodegenerative diseases

Study reviews the advancements in pharmacological treatments for neuropsychiatric syndromes in neurodegenerative disorders, discussing the complexities of managing symptoms such as depression, disinhibition, apathy, psychosis, and agitation to improve patient care.

3 Apr 2024

Skin biopsy test shows promise in diagnosing Parkinson's disease and synucleinopathies

In a paper published in the Journal of the American Medical Association (JAMA), neurologists at Beth Israel Deaconess Medical Center (BIDMC) showed that a simple skin biopsy test detects an abnormal form of alpha-synuclein, the pathological hallmark of Parkinson's disease and the subgroup of neurodegenerative disorders known as synucleinopathies, at high positivity rates.

20 Mar 2024

Groundbreaking study unveils new insights into neurodegenerative disorder symptoms

Identification of clinical disease trajectories in neurodegenerative disorders with natural language processing.

14 Mar 2024

Study reveals pivotal insights into the progression of Parkinson's disease

Parkinson's disease, the second most common type of progressive dementia after Alzheimer's disease, affects nearly 1 million people in the U.S. and an estimated 10 million individuals worldwide.

24 Feb 2024

Researchers introduce a pioneering approach to combat neurodegenerative diseases

Researchers led by Northwestern University and the University of Wisconsin-Madison have introduced a pioneering approach aimed at combating neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease and Amyotrophic lateral sclerosis (ALS).

16 Feb 2024

Rucaparib and its major metabolite exhibit differential biological activity and synergy

Once they enter the body, drugs, apart from carrying out their therapeutic function, are biochemically transformed by the action of the metabolic machinery, a process that facilitates their expulsion.

9 Feb 2024

SynNeurGe: A new biological classification system for Parkinson's disease research

One of the things that makes developing effective treatments for Parkinson's disease so challenging is its complexity.

23 Jan 2024

Protein linked to neurodegeneration turns out to be crucial for healthy brain function

Researchers have discovered that a protein called phosphorylated α-synuclein, which is associated with several neurodegenerative diseases such as Parkinson's disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with each other in a healthy brain.

9 Jan 2024

New test detects Parkinson's disease before symptoms appear

In the development of Parkinson's disease (PD), the changes that will lead to neurodegeneration take place in the brain long before patients show any symptoms.

8 Jan 2024

NEMO protein's crucial role in Parkinson's defense revealed

Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease.

19 Dec 2023

Parkinson's disease a potential pathogenetic factor for coronary artery disease and stroke, study suggests

Researchers performed a two-sample Mendelian randomization (MR) analysis to explore causal associations between Parkinson's disease (PD) and cardio-cerebrovascular diseases.

24 Nov 2023

$3.9 million NIH grant supports research on the Effects of integrated palliative care on Parkinson’s, related dementia

A five-year, $3.9 million grant to study the effects of integrated palliative care on health service outcomes and disparities in Parkinson's disease and Parkinson's disease dementia has been awarded to UTHealth Houston and other institutions by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.

15 Nov 2023