Ligand News and Research

RSS

Non-small cell lung cancer patients survive longer when treated with durvalumab

Non-small cell lung cancer patients survive longer when their treatment includes durvalumab following platinum-based chemoradiotherapy, according to research led by Moffitt Cancer Center.

27 Sep 2018

Researchers discover novel targeting agents to prevent cancer metastasis

Recently, a research team led by Maurizio Pellecchia at the University of California, Riverside, discovered a way for chemotherapy drug paclitaxel to target migrating, or circulating, cancer cells, which are responsible for the development of tumor metastases.

26 Sep 2018

FDA approves Teva’s AJOVY injection for preventive treatment of migraine in adults

Teva Pharmaceutical Industries Ltd. today announced that the U.S. Food and Drug Administration has approved AJOVY injection for the preventive treatment of migraine in adults.

17 Sep 2018

New study links stress with biological disease markers in leukemia patients

Patients with chronic lymphocytic leukemia who feel more stress also have more cancer cells in their blood and elevated levels of three other markers of more advanced disease.

12 Sep 2018

Major pitfall identified in popular prostate cancer PET imaging method

Prostate-specific membrane antigen positron emission tomography imaging has become a popular method for determining the stage of a patient's prostate cancer.

7 Sep 2018

Research solves mystery on nature of EGFR signaling and how it drives development

What do cancer and the growing legs of a fruit fly have in common? They can both be influenced by a single molecule, a protein that tends to call the shots inside of embryos as they develop into living, breathing animals.

28 Aug 2018

'Plastic antibodies' effectively target and eliminate tumor cells

A joint research team from Russia and the U.K. has demonstrated the possibility of developing a new type of anti-neoplastic drugs based on nanoMIPs, or "plastic antibodies." NanoMIPs are synthetic polymers that can function as antibodies, selectively binding to target proteins on the surface of cancer cells.

23 Aug 2018

New drug shows potential to prevent painful side effect of therapy

About 50,000 people in the U.S. are diagnosed annually with head, neck, nasal and oral cancers. Most are treated with radiation, and of those, 70-80 percent develop a painful and debilitating side effect called severe oral mucositis.

20 Aug 2018

Researchers discover new promising target point for cancer and diabetes therapies

If certain signaling cascades are misregulated, diseases like cancer, obesity and diabetes may occur. A mechanism recently discovered by scientists at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie in Berlin and at the University of Geneva has a crucial influence on such signaling cascades and may be an important key for the future development of therapies against these diseases.

15 Aug 2018

Scientists define key binding characteristics of protein associated with heart disease and breast cancer

Galectins attach to other proteins via the carbohydrates on their surfaces (sugar-binding proteins). As such they impact on a range of processes in the cell associated with a number of diseases, including heart disease and breast cancer – the most common cancer in women worldwide, with 1.7 million new cases diagnosed in 2012 alone.

10 Aug 2018

Top AI companies join hands to discover novel drugs for DMD

Insilico Medicine a leader in artificial intelligence for drug discovery, biomarker development and aging research, announced a research collaboration agreement with A2A Pharmaceuticals, Inc. A2A is a biotechnology company headquartered in New York and focused on development of novel drugs for unmet needs in oncology, drug resistant bacterial infections, and other life threatening diseases.

20 Jul 2018

Biophysicists use infrared sensor as new method for drug discovery

Using an infrared sensor, biophysicists at Ruhr-Universität Bochum have succeeded in analyzing quickly and easily which active agents affect the structure of proteins and how long that effect lasts.

19 Jul 2018

Researchers discover mechanism that shuts down cell-to-cell communications pathway

Cellular functions rely on several communications networks that allow cells to rapidly respond to signals affecting the organism.

10 Jul 2018

Study: Mitochondrial DNA in nanovesicles is the alarm that activates antiviral genetic program

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III have provided valuable information about the defense mechanisms of the immune system during the early stages of the response to pathogens such as viruses and bacteria.

10 Jul 2018

Nanofiber-based wound dressings loaded with vitamin D spur production of antimicrobial peptide

Nanofiber-based wound dressings loaded with vitamin D spur the production of an antimicrobial peptide, a key step forward in the battle against surgical site infections, or SSIs.

6 Jul 2018

Newly developed model of retina can predict outcome of perturbation with high precision

Our eye hosts a powerful biological computer, the retina. Understanding how the retina transforms images from the outside world into signals that the brain can interpret would not only result in insights into brain computations, but could also be useful for medicine.

25 Jun 2018

AAA doses first patients in two clinical studies with PSMA-R2 for prostate cancer

Advanced Accelerator Applications S.A., a Novartis company and leader in nuclear medicine theragnostics, today announced that the first patients have been dosed in two Phase I/II clinical studies of radiolabeled PSMA-R2, a urea-based ligand of Prostate-Specific Membrane Antigen, which is commonly expressed on prostate cancer cells.

22 Jun 2018

UC Riverside researcher receives grants to advance cancer, ALS research

Maurizio Pellecchia, who holds the Daniel Hays Chair in Cancer Research at the University of California, Riverside, has received two grants to continue his research aimed at finding therapeutics for cancer, amyotrophic lateral sclerosis, and other neurodegenerative diseases.

21 Jun 2018

Celgene to share new and updated data around novel hematological therapies

Celgene Corporation today announced that data from a broad range of early and late stage studies evaluating Celgene investigational agents and investigational uses of marketed products will be presented at the 23rd European Hematology Association annual meeting in Stockholm, Sweden, from June 14-17, 2018.

22 May 2018

Researchers report new signaling exchange that mediates normal mammary gland development

The human body develops most tissue types during fetal development, in a mother's uterus. Yet one only tissue develops after birth: the mammary gland.

18 May 2018