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Study implicates new gene as driver of motor neuron diseases

Failures in a quality control system that protects protein-building fidelity in cells can lead to motor neuron degeneration and related diseases, according to a new study from an international team co-directed by Scripps Research molecular biologist Claudio Joazeiro, PhD.

16 Sep 2020

Important research on SARS-CoV-2 proteins using proximity labeling

A team of Canadian scientists has recently discovered a wide-range interaction between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and host proteins using proximity-dependent biotinylation approaches.

7 Sep 2020

Improved type of PROTAC enhances intracellular accumulation and protein knockdown

Cancer therapies sometimes involve drugs that mediate the breakdown of specific intracellular proteins that participate in cancer formation and proliferation.

27 Aug 2020

CityU develops CRISPR-assisted method to identify RNA-binding proteins in living cells

While scientists still don't fully understand the diverse nature of RNA molecules, it is believed that the proteins binding to them, called RNA-binding proteins, are associated with many disease formation.

1 Jul 2020

‘Terminator’ protein suppresses tumorigenesis

Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.

3 Jun 2020

The nutritional key to control autoimmunity and cancer

Scientists at the Department of Infection and Immunity of the Luxembourg Institute of Health revealed a novel mechanism through which the immune system can control autoimmunity and cancer.

8 May 2020

Key antibiotic used for treating drug-resistant TB does not work as expected

Crick and Imperial researchers have found that a key antibiotic widely used to treat drug-resistant tuberculosis does not work as expected - a finding which could be used to develop new drugs.

16 Mar 2020

Scientists find link between immune system and high blood pressure in patients with CKD

Detecting threats, sending out response molecules, and altering gene expression--our immune system works tirelessly day and night to protect us from invading pathogens and maintain general health and wellbeing.

3 Mar 2020

New study expands the knowledge on tumor-suppressor role of HERC proteins

The RAF protein could be a therapeutical target to treat the tumor growth in regulated pathways by the p38 protein, according to a new study published in the journal Scientific Reports by a team of experts of the Faculty of Medicine and Health Sciences of the University of Barcelona and the Bellvitge Institute for Biomedical Research.

20 Feb 2020

Scientists pinpoint protein that plays key role in lung cancer and melanoma progression

Scientists from Far Eastern Federal University, University of Geneva (Switzerland), Minjiang University, and Fuzhou University (China) pointed out WDR74 protein playing an important role in lung cancer and melanoma primary tumors/metastases progression.

16 Feb 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

New 'fishing' technique to detect thousands of proteins

A new study published today in the journal Nature Cell Biology reports the use of a novel fishing method, under microscopy, to pick up thousands of proteins that are involved in supervising how the cell skeleton is assembled.

23 Dec 2019

Researchers identify protein that is key for successful viral DNA uncoating

Viruses have been part of animals and humans for eons. When viruses invade a cell, they can infiltrate the nucleus with their genome and become part of the genome of the infected organism. Viruses transfer their genes between various organisms, as well as between tissues containing well differentiated cells inside a living creature. But how they uncoat their well-packed genes and release them to cause infection is largely unknown.

17 Dec 2019

Discovery may provide clues for treatment of autism and schizophrenia

Researchers at the Case Western Reserve University School of Medicine have identified that a gene critical to clearing up unnecessary proteins plays a role in brain development and contributes to the development of autism spectrum disorders and schizophrenia.

25 Nov 2019

Discovery may lead to possible treatments for autism spectrum disorders, schizophrenia

25 Nov 2019

Study: MIB2 improves inflammation by degrading CYLD enzyme

The tumor suppressor CYLD lysine 63 deubiquitinase (CYLD) is a deubiquitinating enzyme that suppresses polyubiquitin-dependent signaling pathways, including the proinflammatory and cell growth-promoting NF-κB pathway.

30 Oct 2019

Researchers find a weak spot in cancer cells

Cancer cells form tumors. This statement, simple as it seems, hides a complex failure of normal immune responses that should eliminate tumor cells from the body before they ever form viable cancer masses.

28 Aug 2019

Schwann cells capable of generating protective myelin over nerves finds research

Researchers have found that Schwann cells, a special type of cells are capable of generating protective myelin sheath covers for the nerves at rates higher than earlier believed.

7 Jul 2019

Study uncovers how simpler organisms manage recycling of incomplete proteins

Our cells' process for transforming genes into useful proteins works much like an automobile factory's assembly line; there are schematics, parts, workers, motors, quality control systems and even recycling crews.

31 May 2019

Scientists develop technique to clear abnormal tau protein from human neurons

Harnessing a probe used to image the brain in diagnosing Alzheimer's disease and related forms of dementia, scientists at Dana-Farber Cancer Institute and Massachusetts General Hospital have successfully cleared patient-derived brain cells of an abnormal protein associated with dementia and other neurogenerative disorders.

10 Apr 2019