Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

Children, adolescents with liver disease may not benefit from vitamin E or metformin

In contrast to previous preliminary data, use of vitamin E or the diabetes drug metformin was not superior to placebo on a measured outcome for treating nonalcoholic fatty liver disease in children and adolescents, according to a study in the April 27 issue of JAMA.

27 Apr 2011

Boehringer Ingelheim initiates enrollment in BI 201335 Phase 3 clinical trial for chronic HCV

Boehringer Ingelheim Pharmaceuticals, Inc. today announced that enrollment has commenced at North American sites in its pivotal Phase 3 clinical trial program for BI 201335, the Company's investigational, oral protease inhibitor for the treatment of chronic hepatitis C virus (HCV).

27 Apr 2011

FDA supports new Hepatitis C drug from Vertex Pharmaceuticals

Vertex pharmaceuticals jumped 10 percent in value on the Nasdaq after U.S. regulators FDA said the company’s experimental hepatitis C drug cures more patients than current therapies.

26 Apr 2011

African-American couples with HIV can benefit from health promotion interventions

Interventions to promote healthy behaviors, including eating more fruits and vegetables, increasing physical activity, and participating in cancer screenings, as well as prevention of HIV/sexually transmitted diseases, appear beneficial for African-American couples who are at high risk for chronic diseases, especially if one of the individuals is living with HIV.

26 Apr 2011

Enrollment commences in Gore Early TIPS study for ascites at Indiana University Hospital

W. L. Gore & Associates today reported the first patient enrolled in the Gore Early TIPS for Ascites Study. The patient was treated at Indiana University Hospital in Indianapolis, Ind.

25 Apr 2011

Echosens's Vibration Controlled Transient Elastography stands out at 46th EASL Congress

On the occasion of the 46th Congress of the European Association for the Study of the Liver, the VCTE(TM) (Vibration Controlled Transient Elastography) from Echosens stood out as a leading technique in the field. It is the only technique able to measure elasticity at a predetermined, controlled frequency (50 Hz), which is essential because elasticity increases as frequency increases.

22 Apr 2011

Transplanting cells from healthy adult livers may help treat genetic liver-lung disorder

Transplanting cells from healthy adult livers may work in treating a genetic liver-lung disorder that affects millions of people worldwide, according to an animal study in the April 18 online edition of the Journal of Clinical Investigation.

22 Apr 2011

Genes linked to obesity may also cause poor weight loss outcomes after gastric bypass surgery

Researchers at Geisinger Health System are studying how genes may affect a patient's ability to lose weight following bariatric surgery. Highlighted in the journal Obesity, the study found that several genes that promote obesity may also result in inferior weight loss outcomes after gastric bypass surgery.

21 Apr 2011

Hypothalamus plays a key role in obesity and type 2 diabetes

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20 Apr 2011

Non-alcoholic fatty liver disease linked to coronary artery disease

Because of the prevalence of obesity in our country, many Americans are expected to develop a serious condition called non-alcoholic fatty liver disease (NAFLD), which can lead to cirrhosis, fibrosis, and in some cases liver failure. It is also one of the best predictors for coronary artery disease.

18 Apr 2011

Study: Low-carb diet greatly reduces liver fat

Curbing carbohydrates is more effective than cutting calories for individuals who want to quickly reduce the amount of fat in their liver, report UT Southwestern Medical Center researchers.

15 Apr 2011

Saint Louis professor develops new high-flow brain bypass procedure

On the cover of a recent edition of the journal Neurosurgery, the highest circulation medical journal in the field, readers saw an artist's intricate depiction of the high-flow brain bypass technique developed by Saint Louis University professor of neurosurgery, Saleem Abdulrauf, M.D.

15 Apr 2011

Walking slows progression of nonalcoholic fatty liver disease in obese people

Walking on a treadmill for one hour a day may slow the progression of nonalcoholic fatty liver disease in obese people with prediabetes by jump-starting their metabolism and slowing the oxidative damage wrought by the condition, say researchers at the Cleveland Clinic.

15 Apr 2011

Consumer group calls for ban on weight loss drugs Alli and Xenical

According to the consumer watchdog Public Citizen, the weight loss drugs Alli and Xenical should be removed from the market because of the growing risk of side effects that include liver damage, pancreatitis and kidney stones.

15 Apr 2011

Scientists identify novel mechanism to control cancer spread

Saint Louis University researchers have identified a novel mechanism to control the traffic of cells and fluid from tissues to lymphatic vessels. It may be possible to harness this mechanism to fight cancer spread from one organ to another organ and improve the effectiveness of vaccines.

11 Apr 2011

Experimental Biology 2011 to be held April 9-13 in Washington, D.C.

The meeting Experimental Biology 2011 (EB 2011) begins April 9 and runs through April 13 at the Walter E. Washington Convention Center in Washington, D.C.

8 Apr 2011

HALT-C trial reveals high mortality rates among patients with HCV

A three-year follow-up study of patients in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis trial revealed that increased mortality among patients with advanced chronic hepatitis C who received long-term peginterferon therapy was attributed to non-liver related causes and occurred primarily in patients with bridging fibrosis.

8 Apr 2011

Scientists identify two molecules that enable cancer spread

For many types of cancer, the original tumor itself is usually not deadly. Instead, it's the spread of a tiny subpopulation of cells from the primary tumor to other parts of the body—the process known as metastasis—that all too often kills the patient.

8 Apr 2011

Increased mortality rates seen in chronic Hep C patients with pre-cirrhotic advanced fibrosis

A three-year follow-up study of patients in the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) trial revealed that increased mortality among patients with advanced chronic hepatitis C who received long-term peginterferon therapy was attributed to non-liver related causes and occurred primarily in patients with bridging fibrosis. No pattern to this excess mortality was evident to researchers, but deaths were unrelated to the peginterferon treatment. Full findings are published in the April issue of Hepatology, a peer-reviewed journal of the American Association for the Study of Liver Diseases (AASLD).

7 Apr 2011

TBL1 levels may help identify obese persons at risk of developing fatty liver

Excess fat around the hips and belly may not really be compatible with current beauty ideals, but, to a certain degree, it is a normal, even vital energy store of our body. However, it is a different matter if the organism stores fat in organs such as the liver, pancreas or muscles. This is a clear sign of a metabolic disorder.

7 Apr 2011

Liver Disease News and Research

Further Reading

Children, adolescents with liver disease may not benefit from vitamin E or metformin

Boehringer Ingelheim initiates enrollment in BI 201335 Phase 3 clinical trial for chronic HCV

FDA supports new Hepatitis C drug from Vertex Pharmaceuticals

African-American couples with HIV can benefit from health promotion interventions

Enrollment commences in Gore Early TIPS study for ascites at Indiana University Hospital

Echosens's Vibration Controlled Transient Elastography stands out at 46th EASL Congress

Transplanting cells from healthy adult livers may help treat genetic liver-lung disorder

Genes linked to obesity may also cause poor weight loss outcomes after gastric bypass surgery

Hypothalamus plays a key role in obesity and type 2 diabetes

Non-alcoholic fatty liver disease linked to coronary artery disease

Study: Low-carb diet greatly reduces liver fat

Saint Louis professor develops new high-flow brain bypass procedure

Walking slows progression of nonalcoholic fatty liver disease in obese people

Consumer group calls for ban on weight loss drugs Alli and Xenical

Scientists identify novel mechanism to control cancer spread

Experimental Biology 2011 to be held April 9-13 in Washington, D.C.

HALT-C trial reveals high mortality rates among patients with HCV

Scientists identify two molecules that enable cancer spread

Increased mortality rates seen in chronic Hep C patients with pre-cirrhotic advanced fibrosis

TBL1 levels may help identify obese persons at risk of developing fatty liver

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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