Liver Disease News and Research

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The liver is one of the largest solid organs of the body. It is located in the upper right part of the abdomen. Most of the organ lies under cover of the rib cage.

GlaxoSmithKline initiates study of PROMACTA in chronic idiopathic thrombocytopenic purpura

GlaxoSmithKline has announced the initiation of a global, open-label, single group trial that will assess the efficacy, safety and tolerability of PROMACTA (eltrombopag olamine) in patients previously treated for chronic idiopathic thrombocytopenic purpura (ITP).

15 Apr 2007

Hepatitis C virus can block other hepatitis C variants from infecting the same cell

There's infection and then there's superinfection - when a cell already infected by a virus gets a second viral infection. But some viruses don't like to share their cells.

5 Apr 2007

NAFLD fibrosis score helps predict advanced fibrosis in patients with nonalcoholic fatty liver disease

Certain routine demographic, clinical, and laboratory values can be used to identify advanced fibrosis in patients with nonalcoholic fatty liver disease (NAFLD).

4 Apr 2007

Critical receptor in liver regeneration identified

In studies in mouse models, researchers at the University of California, San Diego (UCSD) School of Medicine have found that a cellular receptor involved in triggering cell death is also a necessary component of tissue repair and regeneration immediately following liver injury.

2 Apr 2007

New target for removing unwanted ammonia from the body

Thousands of people with liver and kidney disease die every year from too much ammonia in their blood, and scientists from the United States and Japan have found a possible solution.

2 Apr 2007

Growing number of young people have fatty liver disease

Indiana University School of Medicine researchers are taking a closer look at a disease whose incidence is rising as obesity in children increases.

15 Mar 2007

Lactulose improves quality of life in patients with cirrhosis who have minimal hepatic encephalopathy

A study on patients with cirrhosis who had minimal hepatic encephalopathy (MHE), a condition in which behavioral, psychological and neurological changes are associated with advanced liver disease, found that cognitive function and health related quality-of-life improved when they took lactulose. Lactulose is a drug used to help eliminate toxins such as ammonia that are normally cleared by the liver.

5 Mar 2007

The model for end-stage liver disease

A review of the studies on the Model for End-Stage Liver Disease (MELD) found that it is an accurate predictor of survival of patients with a variety of liver diseases, is particularly useful in allocating organs for liver transplants, and can also be used to help determine the course of treatment in certain cases. However, it is possible to improve the accuracy of the model and efforts at refining will continue.

5 Mar 2007

Latest food scare in the U.S. hits Hollywood party scene

Hollywood's celebrities may have been exposed to the hepatitis A virus at one of 13 catered events, in particular a Sports Illustrated's swimsuit party.

28 Feb 2007

Key protein - claudin-1- for hepatitis C virus entry identified

For as many as 200 million people worldwide infected with hepatitis C, a leading cause of chronic liver disease, treatment options are only partially effective. But new research by Rockefeller University scientists points to a potential new target for better drugs: a key protein that resides in human liver cells that hepatitis C requires for entry.

27 Feb 2007

Body Shop founder Roddick reveals she has Hepatitis C

Anita Roddick the founder of the Body Shop has revealed she is suffering from the disease Hepatitis C.

14 Feb 2007

Weight loss supplement - conjugated linoleic acid - shows nasty side effects

A supplement some people turn to in hopes of losing a few pounds may have some previously unknown, unsavory side effects, suggest two new studies.

30 Jan 2007

Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes

Researchers open the way for improved study of hepatitis C virus by devising a novel virus culture system that allows replication of patient-isolated virus in nontransformed hepatocytes, instead of culture-adapted virus strains in transformed cell lines.

23 Jan 2007

Stem cell research discovery could mean 'big things' for cancer

A new discovery in stem cell research may mean big things for cancer patients in the future. Gary Van Zant, Ph.D., and a research team at the University of Kentucky published their findings in Nature Genetics.

14 Jan 2007

Heart transplant patients who receive a donor heart from a person with hepatitis C have a lower rate of survival

A shortage of cardiac organ donors results in a substantial number of deaths among persons awaiting cardiac transplantation. One potential approach for increasing the availability of donors is to broaden the criteria used to identify appropriate donors.

17 Oct 2006

Flu jab not available in the UK for those most vulnerable

There are fears in the UK that people who are vulnerable to flu infections may well have to wait for their annual injection this season.

2 Oct 2006

Eating mandarins reduces the risk of liver disease, hardened arteries and insulin resistance

Researchers in Japan say they believe that eating mandarins may cut the risk of developing liver cancer and other diseases.

12 Sep 2006

Pregnant women with fatty, high-caloric diets increase fetal risk for liver disease, obesity, diabetes

Infants born to women who have diets high in calories and fat during pregnancy have an increased risk of developing liver disease, which can lead to obesity and diabetes later in life, Kevin Grove, a researcher at Oregon Health and Science University and the Developmental Obesity Research Consortium, said on Friday at the 10th International Congress on Obesity in Sydney.

11 Sep 2006

Colchicine delays development of hepatocellular carcinoma in patients with hepatitis virus-related liver cirrhosis

Colchicine, an anti-inflammatory drug most often used to treat gout, prevented liver cancer in patients with hepatitis virus-related end-stage liver disease, according to a new study.