Liver Transplantation News and Research

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Largest description of ST3GAL5 deficiency combined using data from 104 individuals

Researchers have combined the largest description of ST3GAL5 deficiency using detailed natural history data from 104 individuals of Amish ancestry born between 1986 and 2017 with a definite or probable diagnosis of ST3GAL5 deficiency.

6 Feb 2019

Standard method for ranking liver transplant waitlists may not prioritize the sickest candidates

A new study has uncovered that the standard method for ranking patients on the waitlist for lifesaving liver transplantation may not prioritize some of the sickest candidates for the top of the list.

25 Jan 2019

Research suggests possible way to improve survival in African-Americans undergoing liver transplant

Among African-American adults undergoing liver transplant to treat liver cancer, patients whose organ donor was also African-American lived significantly longer than those with a racially unmatched donor, report authors of a new study using national data.

10 Jan 2019

Split liver transplants could save children on wait list finds study

A review analysed 5,300 cases of liver transplants on children across the country. The team of researchers from the Johns Hopkins Medicine looked at the patients who were more likely to survive after a split liver transplant. A split liver transplant is a type of transplant where the recipient receives only a part of the donor’s liver.

18 Dec 2018

Sickest children could benefit from split liver transplants

In a review of registry data for more than 5,300 liver transplants performed in children nationwide, Johns Hopkins Medicine researchers identify the type of patient who is most likely to survive a split liver transplant--receiving only part of a donor's liver--with no additional long-term health risks, which could allow for an increase in the availability of organs.

18 Dec 2018

Liver immune cells contain inert HIV and are unlikely to reproduce infection, study reveals

In a proof-of-principle study, researchers at Johns Hopkins revealed that certain immune system cells found in the human liver, called liver macrophages, contain only inert HIV and aren't likely to reproduce infection on their own in HIV-infected people on long-term antiretroviral therapy.

30 Nov 2018

NIH researchers shed light on causes of HBV-associated acute liver failure

National Institutes of Health scientists and their collaborators found that hepatitis B virus-associated acute liver failure--a rare condition that can turn fatal within days without liver transplantation--results from an uncommon encounter between a highly mutated HBV variant and an unusual immune response in the patient's liver that is mainly sustained by antibody-producing B cells.

14 Nov 2018

Researchers find improvement in liver transplant survival rate among older recipients

An increasing number of older adults are diagnosed with end-stage liver disease. End-stage liver disease is a life-threatening condition in which the liver stops working normally.

23 Oct 2018

Map of human liver cells reveals molecular make-up of individual cells

A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the first time differences between individual cells at the molecular level which can have a profound impact on their behaviour in tissue, tumours and disease.

From 10x Genomics, Inc. 23 Oct 2018

New genome editing tool used to heal genetic disease

Parents of newborns may be familiar with the metabolic disorder phenylketonuria: in Switzerland, all newborn babies are screened for this genetic disease.

8 Oct 2018

Wits doctors transplant liver from HIV positive mother to her child with end-stage liver disease

This was the ethical dilemma faced by doctors at Wits Donald Gordon Medical Centre to save a child's life.

4 Oct 2018

Alnylam submits CTA application to MHRA to initiate Phase 1/2 study of ALN-AAT02

Alnylam Pharmaceuticals, Inc., the leading RNAi therapeutics company, announced today that it has submitted a Clinical Trial Authorization application to the Medicines and Healthcare products Regulatory Agency to initiate a Phase 1/2 study of ALN-AAT02, an investigational RNAi therapeutic targeting alpha-1 antitrypsin for the treatment of AAT deficiency-associated liver disease.

3 Oct 2018

Liver transplant and weight-loss surgery combination offers long-term benefits to obese patients

Obese patients who underwent a life-saving liver transplant and weight-loss surgery at the same time were better able to keep the weight off long term and had fewer metabolic complications than those who lost weight on their own before undergoing a liver transplant, Mayo Clinic research shows.

3 Oct 2018

Researchers win multi-million Euro award to conduct research into liver disease

A team of researchers from the School of Immunology and Microbial Sciences and the Dental Institute has secured a multi-million Euro award to conduct research into liver disease.

16 Aug 2018

Diet-induced obesity synchronizes opposing liver fat metabolic processes in mice

Mice fed a fattening diet develop new liver circadian rhythms that impact the way fat is accumulated and simultaneously burned, according to a new study published in Cell by researchers in the Perelman School of Medicine at the University of Pennsylvania.

27 Jul 2018

BIDMC scientists develop new tool to benefit patients with HCV-associated liver failure

An estimated 3.5 million people in the United States have chronic hepatitis C (HCV), according to the Centers for Disease Control and Prevention.

18 Jun 2018

Study: Medical centers more willing to perform lung transplants for severe alcoholic hepatitis patients

Increasingly, liver transplant centers are changing a long-standing practice of delaying potentially life-saving liver transplantation for patients with severe alcoholic hepatitis until after they stopped drinking alcohol for six months, according to a new study scheduled for presentation at Digestive Disease Week® (DDW) 2018.

22 May 2018

Research leads to new potential treatment for Hereditary Hemorrhagic Telangiectasia

The work of researchers Francesc Viñals and Mariona Graupera at the Bellvitge Biomedical Research Institute - Catalan Institute of Oncology - University of Barcelona, together with Dr. Antoni Riera-Mestre, has led to a new potential treatment for Hereditary Hemorrhagic Telangiectasia or Rendu-Osler Syndrome, a rare disease that affects blood vessels and had no described treatment.

26 Apr 2018

Study reports decreasing rates of liver transplantation among HCC patients in the U.S.

Patients with hepatocellular carcinoma (HCC) waiting for a liver transplant in the USA are now significantly less likely to receive a new liver than they were around a decade ago. A nationwide study presented today at The International Liver Congress™ 2018 in Paris, France, has confirmed that patients with HCC on the liver transplant list in the USA were more than 50% less likely to receive a transplant in 2014-2016 than they were in 2005-2007.

13 Apr 2018

ALIVER produces animated short-film to raise public awareness about liver disease

An animated short-film produced by the ALIVER consortium titled "Life After Liver Failure", premieres tomorrow morning at the BioTech Village in The International Liver Congress 2018.

11 Apr 2018