Lymph Nodes News and Research

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MAPK pathway mutations can provide “precision” treatment targets for head and neck cancer

About one-fifth of often deadly head and neck cancers harbor genetic mutations in a pathway that is key to normal cell growth, and scientists report those mutations, which enable abnormal cancer cell growth, can also make the cancer vulnerable.

28 Apr 2022

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

A plant virus that infects legumes, called cowpea mosaic virus, has a special power that you may not have known about: when injected into a tumor, it triggers the immune system to treat the cancer-;even metastatic cancer-;and prevents it from recurring.

27 Apr 2022

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Researchers developed a highly pathogenic mouse-adapted SARS-CoV-2 strain to model mild, moderate, or COVID-19.

26 Apr 2022

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

My work is focused on looking at the dynamics of B/T cell populations within lymph nodes from patients that had recovered from COVID-19. My role in this research was developing and implementing microscopy image analysis techniques using methods and instrumentation in part supplied by TissueGnostics.

From TissueGnostics 26 Apr 2022

Single-cell atlas of non-hematopoietic cells provides insights into lymphoma stromal biology

Researchers from the University of Tsukuba identify gene expression signatures in different types of lymph nodes cells that play an active role in the development of lymphomas.

21 Apr 2022

Newly discovered immune cell "soldier" could be a good target for immunotherapy

Despite the success of immunotherapy in helping many people with cancer, the majority of patients still do not respond to these treatments. There is need for continued research.

20 Apr 2022

Scientists discover differences in interaction of T-cells within tumor microenvironments

A team led by Northwestern Medicine investigators has discovered differences in the distribution and interaction of T-cells within the microenvironment of different regions of both brain tumors and brain metastases, according to findings published in the journal JCI Insight.

14 Apr 2022

Novel transdermal vaccine delivery for COVID-19 and cancer

Researchers assess the efficacy of a fluorocarbon modified chitosan system for the development of SARS-CoV-2 vaccines and tumor immunotherapy.

13 Apr 2022

Study finds molecular features responsible for the development of metastatic breast cancer

Susana Garcia-Recio, PhD, a research associate in the lab of Charles M. Perou, PhD, at UNC Lineberger Comprehensive Cancer Center, will present findings that identified molecular features responsible for the development and progression of metastatic breast cancer at the 2022 American Association for Cancer Research annual meeting. (Presentation: Abstract LB176/4, Tuesday, April 12, 3:20 p.m. ET, Room 217-219, Ernest N. Morial Convention Center in New Orleans.)

11 Apr 2022

Adding immunotherapy to chemotherapy before surgery improves outcomes for NSCLC patients

Adding the immunotherapy drug nivolumab to chemotherapy before surgery (neoadjuvant) for patients with operable non-small cell lung cancer (NSCLC) — the leading cause of cancer deaths worldwide — reduced the risk of recurrence of the cancer or death by more than one-third, according to results from the phase III CheckMate-816 trial.

11 Apr 2022

New findings cement the lymphatic system’s role in heart repair

Expression of a pro-lymphangiogenic growth factor after heart injury activates the lymphatic system, spurring leukocytes to help clear away dying cells, according to a Northwestern Medicine study published in the Journal of Clinical Investigation.

5 Apr 2022

Study highlights racial disparities among gastrointestinal cancer patients undergoing surgery

African-American adult patients are more likely than white patients to receive substandard gastrointestinal cancer surgery, according a large study led by researchers at Yale Cancer Center. The findings are reported today in the journal JAMA Network Open.

4 Apr 2022

Case study of multi-system inflammatory syndrome in children in a fully vaccinated teenager

A new preprint describes the importance of recognizing this complication, reporting a case of MIS-C without a prior history of this infection.

4 Apr 2022

Adaptive immunity against SARS-CoV-2 is persistent and robust in COVID-convalescent children

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection incites adaptive cellular immune responses. In many SARS-CoV-2 studies, peripheral blood is analyzed to study the immune responses. Now, a new study under consideration at the Nature Portfolio Journal analyzes the peripheral blood, tonsils, and adenoids of children to understand local and systemic immune responses to SARS-CoV-2.

25 Mar 2022

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

The immune system deteriorates with age, making COVID-19 particularly deadly in older people -; but to date, no clinically available medication addresses this key risk factor.

21 Mar 2022

Innate and adaptive immune responses to BNT162b2 vaccination in mice

Researchers analyzed the innate and adaptive responses to the mRNA-based BNT162b2 COVID-19 vaccine in mice.

18 Mar 2022

New findings could change treatment practice and lengthen survival for men with pN1 prostate cancer

Men with microscopic evidence of prostate cancer spreading to their pelvic lymph nodes (LNs) following the surgical resection of the prostate and pelvic lymph nodes (LN) are at a very high risk of dying from prostate cancer. Pelvic LN radiation therapy (RT) is a potentially curative treatment.

15 Mar 2022

Lymph Nodes News and Research

MAPK pathway mutations can provide “precision” treatment targets for head and neck cancer

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

Single-cell atlas of non-hematopoietic cells provides insights into lymphoma stromal biology

Newly discovered immune cell "soldier" could be a good target for immunotherapy

Scientists discover differences in interaction of T-cells within tumor microenvironments

Novel transdermal vaccine delivery for COVID-19 and cancer

Study finds molecular features responsible for the development of metastatic breast cancer

Adding immunotherapy to chemotherapy before surgery improves outcomes for NSCLC patients

New findings cement the lymphatic system’s role in heart repair

Study highlights racial disparities among gastrointestinal cancer patients undergoing surgery

Case study of multi-system inflammatory syndrome in children in a fully vaccinated teenager

Adaptive immunity against SARS-CoV-2 is persistent and robust in COVID-convalescent children

Oral drug that reverses immune aging effectively prevents death in COVID-19 mouse model

Innate and adaptive immune responses to BNT162b2 vaccination in mice

New findings could change treatment practice and lengthen survival for men with pN1 prostate cancer

SARS-CoV-2 in diabetes pathogenesis

Melanoma patients do better on immunotherapy than completion lymph node dissection

Study may pave the way for better multiple sclerosis drugs

Immunology eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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