Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

Cell Genesys reports data from clinical trials of GVAX immunotherapy for prostate cancer

Evaluation of antibody responses in patients with advanced prostate cancer from these studies shows that the GVAX cell-based immunotherapy induces antibody responses to a broad array of prostate cancer- associated antigens, including some not previously known to be associated with prostate cancer.

18 Apr 2007

Peregrine's selective anti-VEGF antibodies shown to be as effective as Avastin

Peregrine Pharmaceuticals has reported that preclinical data presented at the Centennial Annual Meeting of the American Association for Cancer Research (AACR) showed that its monoclonal antibody 2C3, which selectively blocks vascular endothelial growth factor (VEGF) from binding to the second of the two VEGF receptors, demonstrates potent anti-cancer efficacy in a preclinical orthotopic model of pancreatic cancer.

17 Apr 2007

Bacteria can barge inside immune cells

Immune cells that are the body's front-line defense don't necessarily rest quietly until invading bacteria lock onto receptors on their outside skins and rouse them to action, as previously thought. In a new paper, University of Michigan scientists describe their findings that bacteria can barge inside these guard cells and independently initiate a powerful immune response.

14 Apr 2007

New imaging technology with use of novel contrast agent may predict heart attack in waiting

A new imaging technology may hold the key to not only stopping heart attacks in their tracks but also preventing them for ever occurring.

10 Apr 2007

Weak immune response critical to disease that causes most infant hospitalizations

The most common cause of infant hospitalization in the United States, respiratory syncytial virus, infects virtually all children by age two.

7 Apr 2007

Synthetic molecule helps detect heart attack in the making

A new bright spot in heart disease research may soon allow physicians to peer directly into patients' blood vessels and find dangerous cholesterol-filled plaques before they rupture and cause a heart attack.

2 Apr 2007

Why organs fail following massive trauma

Massive trauma, say from a sabertooth tiger attack, meant immediate death for the primitive human.

17 Oct 2006

New class of super NSAIDs

Building on previous work, researchers at the University of Pennsylvania School of Medicine have found that deleting an inflammation enzyme in a mouse model of heart disease slowed the development of atherosclerosis.

12 Sep 2006

New information on how to design nanoparticles that avoid macrophage uptake

Few researchers doubt the potential for nanoparticles to revolutionize the way anticancer drugs and imaging agents are delivered to tumors.

12 Sep 2006

The murine abdominal adipose stromal cell compartment supports the differentiation into endothelial, but not into hematopoietic progenitor cells

World Congress of Cardiology Report - Post-infarct regeneration of the damaged myocardium is critical for treatment of patients with acute coronary syndrome or myocardial infarction.

5 Sep 2006

Researchers find way to decrease risk of atherosclerosis that accompanies long-term use of protease inhibitors

Physiologists may have found a way to decrease the risk of hardening of the arteries that accompanies the long-term use of protease inhibitors, a class of drugs that has emerged as the most effective treatment against HIV and AIDS.

5 Sep 2006

New hope for patients with lung and joint disease

People who suffer from inflammatory conditions such as chronic diseases of the lung, joints and other organs could benefit from a new discovery by scientists at the University of Edinburgh.

4 Sep 2006

Researchers discover how cyclophosphamide chemotherapy drug helps a cancer-killing virus

Researchers here have discovered how a specific chemotherapy drug helps a cancer-killing virus. The virus is being tested in animals for the treatment of incurable human brain tumors.

31 Aug 2006

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung

Drug developers consider the lungs to be an excellent route through which to administer drugs.

21 Aug 2006

Researchers discover one of the malaria parasite's sneakiest tricks

Researchers have discovered one of the malaria parasite's sneakiest tricks--using dead liver cells to cloak and transport itself back into the bloodstream after leaving the liver.

4 Aug 2006

Researchers isolate rare cancer stem cells that cause leukemia

Researchers at Dana-Farber Cancer Institute and Children's Hospital Boston and their colleagues have isolated rare cancer stem cells that cause leukemia in a mouse model of the human disease.

18 Jul 2006

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Various types of carbon-based nanomaterials, such as buckyballs and nanotubes, have shown promise as drug delivery tools and imaging agents, but reports of toxicity associated with some of these materials have raised questions about their ultimate utility in clinical oncology.

10 Jul 2006

Liver cancer is likely caused by cycles of liver cell death and renewal

Research at the University of California, San Diego (UCSD) School of Medicine shows that liver cancer is likely caused by cycles of liver cell death and renewal.

27 Jun 2006

Researchers discover naturally occurring growth factor that stimulates regeneration of injured nerve fibers in the central nervous system

Researchers at Children's Hospital Boston have discovered a naturally occurring growth factor that stimulates regeneration of injured nerve fibers (axons) in the central nervous system.

16 May 2006

Signaling pathways in immune cells may lead to novel HIV treatment

New research on signaling pathways in immune cells bolsters evidence of connections between the central nervous system and the immune system.