Macrophage News and Research

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A macrophage is a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.

TSRI scientists discover first-in-class compounds that target persistent tuberculosis

Tuberculosis has been infecting humans for several millennia, making it one of the most horribly successful diseases in history. Today, it is still a major killer, responsible for some 1.5 million deaths each year.

18 Nov 2015

Birmingham researchers identify how Salmonella infections can lead to life-threatening thrombosis

Researchers from the University of Birmingham have, for the first time, identified how Salmonella infections that have spread to our blood and organs can lead to life-threatening thrombosis.

17 Nov 2015

Scientists show how absence of microbiota has remarkable effect against obesity

In the past few years, research on gut microbiota (that is, all microorganisms, mainly bacteria, inhabiting our gut) has started to unravel its tremendous role in our body, and how it symbiotically affects the functioning of our organs. In particular, microbiota has also an impact on the way calories are absorbed and how fat cells develop.

17 Nov 2015

Negative impact of high-fat diet on red blood cells may promote development of cardiovascular disease

University of Cincinnati researchers have discovered the negative impact a high fat diet has on red blood cells and how these cells, in turn, promote the development of cardiovascular disease.

17 Nov 2015

Vanderbilt study could lead to development of new drugs that relieve pain without causing vascular effects

It's been about a decade since the promise of COX-2 inhibitors -- drugs that relieve arthritis pain and inflammation without the gastrointestinal side effects of other painkillers -- was tempered by the realization that they could cause heart problems in some patients.

13 Nov 2015

New funding for Centenary's life saving research

The Centenary Institute has welcomed the Federal Government’s announcement of funding for 9 new and innovative medical research projects via the latest round of NHMRC grant rounds funding, officially confirmed today.

9 Nov 2015

New book by Virginia Tech researchers explains a set of techniques to model the immune system

The complexity of the human immune response has been difficult to characterize on a 'big picture' level, but researchers at the Virginia Bioinformatics Institute at Virginia Tech have written the book on how it can be done.

5 Nov 2015

Scientists show how specialized cells help each other survive under stress

A team led by scientists from the Florida campus of The Scripps Research Institute and the University of Pittsburgh has shown for the first time how one set of specialized cells survives under stress by manipulating the behavior of key immune system cells.

4 Nov 2015

Rutgers Cancer Institute scientist leads phase III trial of FDA-approved viral melanoma therapy

The U.S. Food and Drug Administration has approved a viral melanoma therapy that was the focus of a phase III clinical trial led by Rutgers Cancer Institute of New Jersey Associate Director for Clinical Science and Chief Surgical Officer Howard L. Kaufman, MD, FACS.

29 Oct 2015

Oncolytic (cancer-killing) viral therapy approved in the U.S. for use against late-stage melanoma

The U.S. Food and Drug Administration announced on Oct. 27 that it has approved, for the first time, an oncolytic (cancer-killing) viral therapy in the United States. The drug was approved for use against late-stage melanoma, a deadly skin cancer that can be difficult to treat.

29 Oct 2015

Scientists develop new strategy to target sarcoidosis

A team of scientists at the Helmholtz Zentrum München together with colleagues of the Ludwig Maximilians University Munich recently developed a new strategy to determine monocyte subsets involved in diseases. The results published in the journal 'Blood' could help facilitating the diagnosis of sarcoidosis and may improve the respective patient management.

23 Oct 2015

Amgen's IMLYGIC receives positive opinion from CHMP for treatment of melanoma

Amgen today announced that the Committee for Medicinal Products for Human Use, the scientific committee of the European Medicines Agency, has adopted a positive opinion recommending that IMLYGIC (talimogene laherparepvec) be granted approval for the treatment of adults with unresectable melanoma that is regionally or distantly metastatic (Stage IIIB, IIIC and IVM1a) with no bone, brain, lung or other visceral disease.

23 Oct 2015

Culprit B cells identified for MS

Researchers have identified a subset of B cells that contribute to multiple sclerosis pathology independently of antibody production.

22 Oct 2015

NAM announces election of three new members from UC San Diego School of Medicine

The National Academy of Medicine announced today the election of three new members from University of California, San Diego School of Medicine: Napoleone Ferrara, MD; Christopher K. Glass, MD, PhD; and Roberto Malinow, MD, PhD. Election to NAM is considered among the highest honors in the fields of health and medicine.

20 Oct 2015

New hope for patients with Duchenne muscular dystrophy

New hope for Duchenne muscular dystrophy (DMD) patients. A mouse genetic study in PLoS Medicine reports that targeting the P2RX7 gene, a purinoreceptor, may halt the progression of DMD.

14 Oct 2015

Single drop of blood in the brain can activate autoimmune response akin to multiple sclerosis

A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS). This is the first demonstration that introduction of blood in the healthy brain is sufficient to cause peripheral immune cells to enter the brain, which then go on to cause brain damage.

12 Oct 2015

Novel technique may help women and their oncologists choose options for treating breast cancer

Biomedical engineers have demonstrated a proof-of-principle technique that could give women and their oncologists more personalized information to help them choose options for treating breast cancer.

6 Oct 2015

Duke Medicine scientists use transparent fish to show how Cryptococcal meningitis takes over the brain

Scientists at Duke Medicine are using transparent fish to watch in real time as Cryptococcal meningitis takes over the brain. The resulting images are worthy of a sci-fi movie teaser, but could be valuable in disrupting the real, crippling brain infection that kills more than 600,000 people worldwide each year.

29 Sep 2015

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

"We are pleased to receive positive CHMP opinions for Kyprolis and BLINCYTO as this is an important step in providing new treatment options for patients in Europe with rare forms of cancer," said Sean E. Harper, M.D., executive vice president of Research and Development at Amgen.

25 Sep 2015

Radboud university medical center reveals how BCG vaccine works against tuberculosis

Not only the acquired immune system but also the innate immune system has a memory. And the BCG vaccine against tuberculosis can stimulate this memory. After a BCG vaccination the innate immune system responds better to a wide range of other infections. Mihai Netea and colleagues from Radboud university medical center discovered and described how that works. They think that the old vaccine could be useful for specific target groups, such as the elderly.

23 Sep 2015

Macrophage News and Research

Further Reading

TSRI scientists discover first-in-class compounds that target persistent tuberculosis

Birmingham researchers identify how Salmonella infections can lead to life-threatening thrombosis

Scientists show how absence of microbiota has remarkable effect against obesity

Negative impact of high-fat diet on red blood cells may promote development of cardiovascular disease

Vanderbilt study could lead to development of new drugs that relieve pain without causing vascular effects

New funding for Centenary's life saving research

New book by Virginia Tech researchers explains a set of techniques to model the immune system

Scientists show how specialized cells help each other survive under stress

Rutgers Cancer Institute scientist leads phase III trial of FDA-approved viral melanoma therapy

Oncolytic (cancer-killing) viral therapy approved in the U.S. for use against late-stage melanoma

Scientists develop new strategy to target sarcoidosis

Amgen's IMLYGIC receives positive opinion from CHMP for treatment of melanoma

Culprit B cells identified for MS

NAM announces election of three new members from UC San Diego School of Medicine

New hope for patients with Duchenne muscular dystrophy

Single drop of blood in the brain can activate autoimmune response akin to multiple sclerosis

Novel technique may help women and their oncologists choose options for treating breast cancer

Duke Medicine scientists use transparent fish to show how Cryptococcal meningitis takes over the brain

Amgen gets positive CHMP opinions for Kyprolis (carfilzomib) and BLINCYTO (blinatumomab)

Radboud university medical center reveals how BCG vaccine works against tuberculosis

Microbiology eBook

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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